Canine Recombinant IL13RA2 protein, His Tag (V2LY-0526-LY1268)

Name: Canine Recombinant IL13RA2 protein, His Tag
SKU: V2LY-0526-LY1268
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Canine

Tag

His Tag

Protein Construction

This product is Canine Recombinant IL13RA2 protein, His Tag consist of Amino Acid: 1-338 and predicts a molecular mass of 38.6 kDa.

Molecule Mass

38.6 kDa

Verified

HPLC

Sequence

Amino Acid: 1-338

Species

Canine

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥95% as determined by SDS-PAGE. ≥90% as determined by SEC-HPLC.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Interleukin 13 Receptor Subunit Alpha 2

Function

Binds as a monomer with high affinity to interleukin-13 (IL13), but not to interleukin-4 (IL4).

Biological Process

Cytokine-mediated signaling pathway Source: GO_Central
Immunoglobulin mediated immune response Source: Ensembl
Negative regulation of immunoglobulin production Source: Ensembl
Negative regulation of mast cell degranulation Source: Ensembl

Cellular Location

Membrane

Topology

Extracellular: 27-343
Helical: 344-363
Cytoplasmic: 364-380

Subham, S., Jeppson, J. D., Schatmeyer, B., Forman, S. J., Brown, C. E., & Akhavan, D. (2023). Protein kinase C is an upstream regulator of IL13Ra2 and small molecular activator enhances CAR T mediated killing. Cancer Research, 83(7_Supplement), 3235-3235.

Hotblack, A., Wawrzyniecka, P., Cheng, G. W. K., Nannini, F., Pule, M., & Straathof, K. (2022). IMMU-16. Next-generation CAR T-cells targeting IL13RA2 and secreting IL-15 achieve durable tumour clearance in pre-clinical model of diffuse midline glioma. Neuro-Oncology, 24(Suppl 1), i85.

Rossmeisl, J. H., Herpai, D., Quigley, M., Cecere, T. E., Robertson, J. L., D’Agostino, R. B., ... & Debinski, W. (2021). Phase I trial of convection-enhanced delivery of IL13RA2 and EPHA2 receptor targeted cytotoxins in dogs with spontaneous intracranial gliomas. Neuro-oncology, 23(3), 422-434.

Zeng, J., Zhang, J., Yang, Y. Z., Wang, F., Jiang, H., Chen, H. D., ... & Hu, W. M. (2020). IL13RA2 is overexpressed in malignant gliomas and related to clinical outcome of patients. American Journal of Translational Research, 12(8), 4702.

Wang, M., Yao, R., & Wang, Y. (2020). Silencing of IL13RA2 promotes partial epithelial‐mesenchymal transition in hepatocellular carcinoma via ERK signaling pathway activation. FEBS Open bio, 10(2), 229-236.

Verstockt, B., Verstockt, S., Creyns, B., Tops, S., Van Assche, G., Gils, A., ... & Breynaert, C. (2019). Mucosal IL13RA2 expression predicts nonresponse to anti‐TNF therapy in Crohn's disease. Alimentary Pharmacology & Therapeutics, 49(5), 572-581.

Chong, S. T., Tan, K. M., Kok, C. Y., Guan, S. P., Lai, S. H., Lim, C., ... & Ngeow, J. (2019). IL13RA2 is differentially regulated in papillary thyroid carcinoma vs follicular thyroid carcinoma. The Journal of Clinical Endocrinology & Metabolism, 104(11), 5573-5584.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Canine Recombinant IL13RA2 protein, hFc Tag (CAT#: V2LY-0526-LY1267)

Human Recombinant IL13RA2 protein, ECD, Biotin Conjugated, hFc & AVI Tag (CAT#: V2LY-0526-LY4747)

Human Recombinant IL13RA2 protein, ECD, hFc Tag (CAT#: V2LY-0526-LY4748)

Human Recombinant IL13RA2 protein, ECD, His Tag (CAT#: V2LY-0526-LY4749)

Human Recombinant IL13RA2 protein, ECD, His Tag-1 (CAT#: V2LY-0526-LY4750)

Human Recombinant IL13RA2 protein, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY4751)

Human Recombinant IL13RA2 protein, His & hFc Tag (CAT#: V2LY-0526-LY4752)

Human Recombinant IL13RA2 protein, Biotin Conjugated, His Tag (CAT#: V2LY-0526-LY4753)

Mouse Recombinant IL13RA2 protein, ECD, hFc Tag (CAT#: V2LY-0526-LY8480)

Mouse Recombinant IL13RA2 protein, ECD, Fc Tag (CAT#: V2LY-0526-LY8481)

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Human Recombinant IL13RA2 protein, Biotin Conjugated, His Tag (CAT#: V2LY-0526-LY4753)

Rat Anti-IL13RA2 Recombinant Antibody (CBYY-I1339) (CAT#: CBMAB-I2509-YY)

Rat Recombinant IL13RA2 protein, hFc Tag (CAT#: V2LY-0526-LY9440)

Human Recombinant IL13RA2 protein, His & hFc Tag (CAT#: V2LY-0526-LY4752)

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Mouse Anti-IL13RA2 Recombinant Antibody (CBYY-I1578) (CAT#: CBMAB-I2748-YY)

Human Recombinant IL13RA2 protein, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY4751)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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