CASP3 Matched Antibody Pair (183) (APMAB-183LY)

Name: CASP3 Matched Antibody Pair (183)
SKU: APMAB-183LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet References Q & As Review & reward Protocols Associated Products

Specifications

ApplIcation

Sandwich ELISA

Specificity

Human

Capture Antibody

Rabbit anti-CASP3 polyclonal antibody, 100 ug

Detection Antibody

Anti-CASP3 Mouse monoclonal, IgG2a antibody, 20 ug

Dilutions

10 ng/ml-100 ng/ml

Format

Liquid

Storage

Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.

Introduction

The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. [provided by RefSeq, Aug 2017]

Alternative Names

Caspase 3; Caspase 3, Apoptosis-Related Cysteine Peptidase; Caspase 3, Apoptosis-Related Cysteine Protease; SREBP Cleavage Activity 1; Cysteine Protease CPP32; Protein Yama; EC 3.4.22.56; Apopain; CASP-3;

Entrez Gene ID

836

UniProt ID

P42574

More Infomation

Yildiz Gulhan, P., Eroz, R., Ataoglu, O., İnce, N., Davran, F., Öztürk, C. E., ... & Balbay, O. A. (2021). The evaluation of both the expression and serum protein levels of Caspase‐3 gene in patients with different degrees of SARS‐CoV2 infection. Journal of Medical Virology.

Awazu, M., Yamaguchi, Y., Nagata, M., Miura, M., & Hida, M. (2021). Caspase-3 regulates ureteric branching in mice via cell migration. Biochemical and Biophysical Research Communications, 559, 28-34.

Yousefi, M., Koopaie, M., Karimi, R., Kermani, F. M., Kolahdooz, S., & Shamshiri, A. (2021). Effect of photodynamic therapy on expression of HRAS, NRAS and caspase 3 genes at mRNA levels, apoptosis of head and neck squamous cell carcinoma cell line. Photodiagnosis and Photodynamic Therapy, 33, 102142.

Wang, Y. J., Liu, M. G., Wang, J. H., Cao, W., Wu, C., Wang, Z. Y., ... & Li, X. Y. (2020). Restoration of cingulate long-term depression by enhancing non-apoptotic caspase 3 alleviates peripheral pain hypersensitivity. Cell Reports, 33(6), 108369.

Suzuki, T., Ichii, O., Nakamura, T., Horino, T., Elewa, Y. H. A., & Kon, Y. (2020). Immune-associated renal disease found in caspase 3-deficient mice. Cell and tissue research, 379(2), 323-335.

Hentzen, N. B., Mogaki, R., Otake, S., Okuro, K., & Aida, T. (2020). Intracellular Photoactivation of Caspase-3 by Molecular Glues for Spatiotemporal Apoptosis Induction. Journal of the American Chemical Society, 142(18), 8080-8084.

Han, R., Chen, X., Li, Y., Zhang, S., Li, R., & Lu, L. (2019). MicroRNA-34a suppresses aggressiveness of hepatocellular carcinoma by modulating E2F1, E2F3, and Caspase-3. Cancer management and research, 11, 2963.

Bernard, A., Chevrier, S., Beltjens, F., Dosset, M., Viltard, E., Lagrange, A., ... & Boidot, R. (2019). Cleaved caspase-3 transcriptionally regulates angiogenesis-promoting chemotherapy resistance. Cancer research, 79(23), 5958-5970.

Vera‐Lozada, G., Segges, P., Stefanoff, C. G., Barros, M. H. M., Niedobitek, G., & Hassan, R. (2018). Pathway‐focused gene expression profiles and immunohistochemistry detection identify contrasting association of caspase 3 (CASP3) expression with prognosis in pediatric classical Hodgkin lymphoma. Hematological oncology, 36(4), 663-670.

Zhou, M., Liu, X., Li, Z., Huang, Q., Li, F., & Li, C. Y. (2018). Caspase‐3 regulates the migration, invasion and metastasis of colon cancer cells. International journal of cancer, 143(4), 921-930.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Mouse Casp3 ELISA Kit (CAT#: V2LY-0626-LY1728)

Rat Casp3 ELISA Kit (CAT#: V2LY-0626-LY1846)

Cattle CASP3 ELISA Kit (CAT#: V2LY-0626-LY2488)

Human CASP3 ELISA Kit (CAT#: V2LY-0626-LY4257)

Rat CASP3 ELISA Kit (2) (CAT#: V2LY-0626-LY664)

Rabbit CASP3 ELISA Kit (CAT#: V2LY-0626-LY722)

Dog CASP3 ELISA Kit (CAT#: V2LY-0626-LY737)

Pig CASP3 ELISA Kit (CAT#: V2LY-0626-LY943)

Human Recombinant CASP3 protein, His Tag (CAT#: V2LY-0526-LY2599)

Related Products

Mouse Casp3 ELISA Kit (CAT#: V2LY-0626-LY1728)

Mouse Anti-CASP3 Recombinant Antibody (CBT2) (CAT#: V2LY-0625-LY3880)

Rabbit Anti-CASP3 Recombinant Antibody (CBYY-C0975) (CAT#: CBMAB-C2412-YY)

Human CASP3 ELISA Kit (CAT#: V2LY-0626-LY4257)

Mouse Anti-CASP3 Recombinant Antibody (
30C11) (CAT#: V2LY-0725-LY221)

Mouse Anti-CASP3 Recombinant Antibody (4-1-18) (CAT#: CBMAB-C1268-LY)

Mouse Anti-CASP3 Recombinant Antibody (CBT3353) (CAT#: V2LY-0625-LY249)

Rat Casp3 ELISA Kit (CAT#: V2LY-0626-LY1846)

Mouse Anti-CASP3 Recombinant Antibody (3F49) (CAT#: CBMAB-C1122-LY)

Mouse Anti-CASP3 Recombinant Antibody (CBT2580) (CAT#: V2LY-0625-LY246)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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