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CASP3 Matched Antibody Pair (183) (APMAB-183LY)

This antibody pair set can be used for detecting and quantifying protein level of human CASP3.
See all CASP3 antibodies

Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-CASP3 polyclonal antibody, 100 ug
Detection Antibody
Anti-CASP3 Mouse monoclonal, IgG2a antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. [provided by RefSeq, Aug 2017]
Alternative Names
Caspase 3; Caspase 3, Apoptosis-Related Cysteine Peptidase; Caspase 3, Apoptosis-Related Cysteine Protease; SREBP Cleavage Activity 1; Cysteine Protease CPP32; Protein Yama; EC 3.4.22.56; Apopain; CASP-3;
Entrez Gene ID
836
UniProt ID
P42574

Yildiz Gulhan, P., Eroz, R., Ataoglu, O., İnce, N., Davran, F., Öztürk, C. E., ... & Balbay, O. A. (2021). The evaluation of both the expression and serum protein levels of Caspase‐3 gene in patients with different degrees of SARS‐CoV2 infection. Journal of Medical Virology.

Awazu, M., Yamaguchi, Y., Nagata, M., Miura, M., & Hida, M. (2021). Caspase-3 regulates ureteric branching in mice via cell migration. Biochemical and Biophysical Research Communications, 559, 28-34.

Yousefi, M., Koopaie, M., Karimi, R., Kermani, F. M., Kolahdooz, S., & Shamshiri, A. (2021). Effect of photodynamic therapy on expression of HRAS, NRAS and caspase 3 genes at mRNA levels, apoptosis of head and neck squamous cell carcinoma cell line. Photodiagnosis and Photodynamic Therapy, 33, 102142.

Wang, Y. J., Liu, M. G., Wang, J. H., Cao, W., Wu, C., Wang, Z. Y., ... & Li, X. Y. (2020). Restoration of cingulate long-term depression by enhancing non-apoptotic caspase 3 alleviates peripheral pain hypersensitivity. Cell Reports, 33(6), 108369.

Suzuki, T., Ichii, O., Nakamura, T., Horino, T., Elewa, Y. H. A., & Kon, Y. (2020). Immune-associated renal disease found in caspase 3-deficient mice. Cell and tissue research, 379(2), 323-335.

Hentzen, N. B., Mogaki, R., Otake, S., Okuro, K., & Aida, T. (2020). Intracellular Photoactivation of Caspase-3 by Molecular Glues for Spatiotemporal Apoptosis Induction. Journal of the American Chemical Society, 142(18), 8080-8084.

Han, R., Chen, X., Li, Y., Zhang, S., Li, R., & Lu, L. (2019). MicroRNA-34a suppresses aggressiveness of hepatocellular carcinoma by modulating E2F1, E2F3, and Caspase-3. Cancer management and research, 11, 2963.

Bernard, A., Chevrier, S., Beltjens, F., Dosset, M., Viltard, E., Lagrange, A., ... & Boidot, R. (2019). Cleaved caspase-3 transcriptionally regulates angiogenesis-promoting chemotherapy resistance. Cancer research, 79(23), 5958-5970.

Vera‐Lozada, G., Segges, P., Stefanoff, C. G., Barros, M. H. M., Niedobitek, G., & Hassan, R. (2018). Pathway‐focused gene expression profiles and immunohistochemistry detection identify contrasting association of caspase 3 (CASP3) expression with prognosis in pediatric classical Hodgkin lymphoma. Hematological oncology, 36(4), 663-670.

Zhou, M., Liu, X., Li, Z., Huang, Q., Li, F., & Li, C. Y. (2018). Caspase‐3 regulates the migration, invasion and metastasis of colon cancer cells. International journal of cancer, 143(4), 921-930.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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