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CLDN1 Matched Antibody Pair (273) (APMAB-273LY)

This antibody pair set can be used for detecting and quantifying protein level of human CLDN1.
See all CLDN1 antibodies

Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-CLDN1 polyclonal antibody, 100 ug
Detection Antibody
Anti-CLDN1 Mouse monoclonal, IgG2a antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome. [provided by RefSeq, Jul 2008]
Alternative Names
Claudin 1; Senescence-Associated Epithelial Membrane Protein 1; SEMP1; CLD1; Senescence-Associated Epithelial Membrane Protein; Claudin-1; ILVASC;
Entrez Gene ID
9076
UniProt ID
O95832

Bhat, A. A., Syed, N., Therachiyil, L., Nisar, S., Hashem, S., Macha, M. A., ... & Haris, M. (2020). Claudin-1, a double-edged sword in cancer. International journal of molecular sciences, 21(2), 569.

Qian, X., Xu, C., Wu, B., Tang, H., Zhao, P., & Qi, Z. (2020). SNORD126 Promotes Hepatitis C Virus Infection by Upregulating Claudin-1 via Activation of PI3K-AKT Signaling Pathway. Frontiers in Microbiology, 11, 2186.

Tong, H., Li, T., Qiu, W., & Zhu, Z. (2019). Claudin‑1 silencing increases sensitivity of liver cancer HepG2 cells to 5‑fluorouracil by inhibiting autophagy. Oncology letters, 18(6), 5709-5716.

Masterson, J. C., Biette, K. A., Hammer, J. A., Nguyen, N., Capocelli, K. E., Saeedi, B. J., ... & Furuta, G. T. (2019). Epithelial HIF-1α/claudin-1 axis regulates barrier dysfunction in eosinophilic esophagitis. The Journal of clinical investigation, 129(8), 3224-3235.

Colpitts, C. C., Tawar, R. G., Mailly, L., Thumann, C., Heydmann, L., Durand, S. C., ... & Baumert, T. F. (2018). Humanisation of a claudin-1-specific monoclonal antibody for clinical prevention and cure of HCV infection without escape. Gut, 67(4), 736-745.

Devriese, S., Eeckhaut, V., Geirnaert, A., Van den Bossche, L., Hindryckx, P., Van de Wiele, T., ... & Laukens, D. (2017). Reduced mucosa-associated Butyricicoccus activity in patients with ulcerative colitis correlates with aberrant claudin-1 expression. Journal of Crohn's and Colitis, 11(2), 229-236.

Cherradi, S., Ayrolles-Torro, A., Vezzo-Vié, N., Gueguinou, N., Denis, V., Combes, E., ... & Del Rio, M. (2017). Antibody targeting of claudin-1 as a potential colorectal cancer therapy. Journal of Experimental & Clinical Cancer Research, 36(1), 1-13.

Moldvay, J., Fábián, K., Jäckel, M., Németh, Z., Bogos, K., Furák, J., ... & Schaff, Z. (2017). Claudin-1 protein expression is a good prognostic factor in non-small cell lung cancer, but only in squamous cell carcinoma cases. Pathology & Oncology Research, 23(1), 151-156.

Hahn-Strömberg, V., Askari, S., Ahmad, A., Befekadu, R., & Nilsson, T. K. (2017). Expression of claudin 1, claudin 4, and claudin 7 in colorectal cancer and its relation with CLDN DNA methylation patterns. Tumor Biology, 39(4), 1010428317697569.

Zheng, G., Fon, G. V., Meixner, W., Creekmore, A., Zong, Y., Dame, M. K., ... & Wiley, J. W. (2017). Chronic stress and intestinal barrier dysfunction: Glucocorticoid receptor and transcription repressor HES1 regulate tight junction protein Claudin-1 promoter. Scientific reports, 7(1), 1-12.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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