Cynomolgus Recombinant CD16A protein, Biotin Conjugated, His & AVI Tag (V2LY-0526-LY1407)

Name: Cynomolgus Recombinant CD16A protein, Biotin Conjugated, His & AVI Tag
SKU: V2LY-0526-LY1407
Rating: 5 (1 reviews)

See all FCGR3A antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Cynomolgus

Tag

His & AVI Tag

Protein Construction

This product is Cynomolgus Recombinant CD16A protein, Biotin Conjugated, His & AVI Tag consist of Amino Acid: 1-208 and predicts a molecular mass of 25.15 kDa.

Molecule Mass

25.15 kDa

Verified

HPLC

Conjugates

Biotin

Sequence

Amino Acid: 1-208

Species

Cynomolgus

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥90% as determined by SDS-PAGE. ≥90% as determined by SEC-HPLC.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile Tris, NaCl, Glutathione, EDTA, DTT, Glycerol

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Fc Fragment Of IgG Receptor IIIa

Alternative Names

Fc Fragment Of IgG Receptor IIIa; Fc Fragment Of IgG; Low Affinity IIIa; Receptor (CD16a); Fc Gamma Receptor IIIa; IgG Fc Receptor III-2; Fc-Gamma RIII-Alpha; Fc-Gamma RIIIa; Fc-Gamma RIII; CD16a Antigen; FCRIIIA; FCR-10; FCRIII; FCGR3; CD16A; IGFR3; FCG3;

Research Area

Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis.

Biological Process

Cell surface receptor signaling pathway Source: GO_Central
Immune response Source: ProtInc
Regulation of immune response Source: GO_Central

Cellular Location

Secreted; Cell membrane. Exists also as a soluble receptor.

Involvement in disease

Immunodeficiency 20 (IMD20):
A rare autosomal recessive primary immunodeficiency characterized by functional deficiency of NK cells. Affected individuals typically present with severe herpes viral infections, particularly Epstein Barr virus (EBV), and human papillomavirus (HPV).

Topology

Extracellular: 17-208
Helical: 209-229
Cytoplasmic: 230-254

PTM

Glycosylated. Contains high mannose- and complex-type oligosaccharides. Glycosylation at Asn-180 is mandatory for high affinity binding to the Fc and for discrimination between fucosylated and afucosylated IgG glycoforms.
The soluble form is produced by a proteolytic cleavage.

Ebonwu, J., Lassaunière, R., Paximadis, M., Strehlau, R., Gray, G. E., Kuhn, L., & Tiemessen, C. T. (2022). FCGR3A gene duplication, FcγRIIb-232TT and FcγRIIIb-HNA1a associate with an increased risk of vertical acquisition of HIV-1. Plos one, 17(9), e0273933.

Sun, K., Fei, X., Xu, M., Xu, R., & Xu, M. (2022). FCGR3A Is a Prognostic Biomarker and Correlated with Immune Infiltrates in Lower-Grade Glioma. Journal of Oncology, 2022.

Litjens, N., Peeters, A., Gestel, J. K. V., Klepper, M., & Betjes, M. (2021). The FCGR3A 158 V/V-genotype is associated with decreased survival of renal allografts with chronic active antibody-mediated rejection. Scientific Reports, 11(1), 1-11.

Márquez Pete, N., Maldonado Montoro, M. D. M., Pérez Ramírez, C., Martínez Martínez, F., Martínez de la Plata, J. E., Daddaoua, A., & Jiménez Morales, A. (2021). Influence of the FCGR2A rs1801274 and FCGR3A rs396991 Polymorphisms on Response to Abatacept in Patients with Rheumatoid Arthritis. Journal of personalized medicine, 11(6), 573.

Izadi, N., Sun, M., Mace, E. M., O’Gorman, M. R., & Church, J. A. (2021). Undetectable NK Cells due to the FCGR3A Variant, L66H, Which May Not Be Directly Disease-Causing. Journal of Clinical Immunology, 41(8), 1957-1959.

Liu, B., Maier, L. A., Hamzeh, N., MacPhail, K., Mroz, M. M., Liu, H., & Li, L. (2019). Polymorphism of FCGR3A gene in chronic beryllium disease. Genes & Immunity, 20(6), 493-499.

Paul, P., Pedini, P., Lyonnet, L., Di Cristofaro, J., Loundou, A., Pelardy, M., ... & Picard, C. (2019). FCGR3A and FCGR2A genotypes differentially impact allograft rejection and patients' survival after lung transplant. Frontiers in Immunology, 10, 1208.

Jiménez Morales, A., Maldonado‐Montoro, M., Martinez de la Plata, J. E., Pérez Ramírez, C., Daddaoua, A., Alarcón Payer, C., ... & Garcia Collado, C. (2019). FCGR2A/FCGR3A gene polymorphisms and clinical variables as predictors of response to tocilizumab and rituximab in patients with rheumatoid arthritis. The Journal of Clinical Pharmacology, 59(4), 517-531.

Mahaweni, N. M., Olieslagers, T. I., Rivas, I. O., Molenbroeck, S. J., Groeneweg, M., Bos, G. M., ... & Wieten, L. (2018). A comprehensive overview of FCGR3A gene variability by full-length gene sequencing including the identification of V158F polymorphism. Scientific reports, 8(1), 1-11.

Romero-Cara, P., Torres-Moreno, D., Pedregosa, J., Vílchez, J. A., García-Simón, M. S., Ruiz-Merino, G., ... & Conesa-Zamora, P. (2018). A FCGR3A polymorphism predicts anti-drug antibodies in chronic inflammatory bowel disease patients treated with anti-TNF. International journal of medical sciences, 15(1), 10.

Sun, K., Fei, X., Xu, M., Xu, R., & Xu, M. (2022). FCGR3A Is a Prognostic Biomarker and Correlated with Immune Infiltrates in Lower-Grade Glioma. Journal of Oncology, 2022.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Cynomolgus Recombinant CD16A protein, Biotin Conjugated, His & AVI Tag?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Cynomolgus Recombinant CD16A protein, Biotin Conjugated, His Tag (CAT#: V2LY-0526-LY1408)

Cynomolgus Recombinant CD16A protein, His Tag (CAT#: V2LY-0526-LY1409)

Human Recombinant FCGR3A (F176) protein, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY2683)

Human Recombinant FCGR3A (F176) protein, His & AVI Tag (CAT#: V2LY-0526-LY2684)

Human Recombinant FCGR3A (F176) protein, His Tag (CAT#: V2LY-0526-LY2685)

Human Recombinant FCGR3A (F176) protein, His Tag-1 (CAT#: V2LY-0526-LY2686)

Human Recombinant FCGR3A (F176) protein, His Tag-2 (CAT#: V2LY-0526-LY2687)

Human Recombinant FCGR3A (V176) protein, His & AVI Tag (CAT#: V2LY-0526-LY2688)

Human Recombinant FCGR3A (V176) protein, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY2689)

Human Recombinant FCGR3A (V176) protein, His Tag (CAT#: V2LY-0526-LY2690)

Related Products

Mouse Anti-FCGR3A Recombinant Antibody (3G8) (CAT#: CBMAB-F0079-CQ)

Mouse Anti-FCGR3A Recombinant Antibody (CBXF-0468) (CAT#: CBMAB-F0383-CQ)

Mouse Anti-FCGR3A Recombinant Antibody (AG70) (CAT#: V2LY-0524-LY11)

Mouse Anti-FCGR3A Recombinant Antibody (CBXF-3682) (CAT#: CBMAB-F0078-CQ)

Human Recombinant FCGR3A (V176) protein, His & AVI Tag (CAT#: V2LY-0526-LY2688)

Mouse Anti-FCGR3A Recombinant Antibody (F0079) (CAT#: V2LY-0925-LY910)

Human Recombinant FCGR3A (F176) protein, His & AVI Tag (CAT#: V2LY-0526-LY2684)

Mouse Anti-FCGR3A Recombinant Antibody (CBXF-0469) (CAT#: CBMAB-F2289-CQ)

Mouse Anti-FCGR3A Recombinant Antibody (CB16) (CAT#: V2LY-0925-LY912)

Mouse Anti-FCGR3A Recombinant Antibody (CBXF-2018) (CAT#: V2LY-0925-LY921)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry