Cynomolgus Recombinant CD66C protein, His Tag (V2LY-0526-LY1467)

Name: Cynomolgus Recombinant CD66C protein, His Tag
SKU: V2LY-0526-LY1467
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Cynomolgus

Tag

His Tag

Protein Construction

This product is Cynomolgus Recombinant CD66C protein, His Tag consist of Amino Acid: 1-323 and predicts a molecular mass of 33.3 kDa.

Molecule Mass

33.3 kDa

Verified

HPLC

Sequence

Amino Acid: 1-323

Species

Cynomolgus

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥95% as determined by SDS-PAGE. ≥95% as determined by SEC-HPLC.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile Tris, NaCl, Trehalose, CHAPS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Carcinoembryonic Antigen Related Cell Adhesion Molecule 6

Function

Cell surface glycoprotein that plays a role in cell adhesion and tumor progression (PubMed:2803308, PubMed:2022629, PubMed:1378450, PubMed:8776764, PubMed:11590190, PubMed:10910050, PubMed:14724575, PubMed:16204051).
Intercellular adhesion occurs in a calcium- and fibronectin-independent manner (PubMed:2022629, PubMed:16204051).
Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM5 and CEACAM8 (PubMed:2803308, PubMed:2022629, PubMed:8776764, PubMed:11590190, PubMed:16204051).
Heterophilic interaction with CEACAM8 ^oCcurs in activated neutrophils (PubMed:8776764).
Plays a role in neutrophil adhesion to cytokine-activated endothelial cells (PubMed:1378450).
Plays a role as an oncogene by promoting tumor progression; positively regulates cell migration, cell adhesion to endothelial cells and cell invasion (PubMed:16204051).
Also involved in the metastatic cascade process by inducing gain resistance to anoikis of pancreatic adenocarcinoma and colorectal carcinoma cells (PubMed:10910050, PubMed:14724575).

Biological Process

Apoptotic process Source: UniProtKB-KW
Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
Homophilic cell adhesion via plasma membrane adhesion molecules Source: UniProtKB
Leukocyte migration Source: Reactome
Negative regulation of anoikis Source: UniProtKB
Neutrophil degranulation Source: Reactome
Positive regulation of cell migration Source: UniProtKB
Positive regulation of cell population proliferation Source: BHF-UCL
Positive regulation of endothelial cell-matrix adhesion via fibronectin Source: UniProtKB
Positive regulation of heterotypic cell-cell adhesion Source: UniProtKB
Signal transduction Source: UniProtKB

Cellular Location

Cell membrane; Apical cell membrane; Cell surface. Localized to the apical glycocalyx surface.

PTM

Glycosylated.

An, F., Zheng, C., Zhang, G., Zhou, L., Wu, Y., Hou, Z., ... & Zhan, Q. (2021). Carcinoembryonic Antigen Related Cell Adhesion Molecule 6 Promotes Carcinogenesis of Gastric Cancer and Anti-CEACAM6 Fluorescent Probe Can Diagnose the Precancerous Lesions. Frontiers in Oncology, 11.

Rahman, S. K., Ansari, M. A., Gaur, P., Ahmad, I., Chakravarty, C., Verma, D. K., ... & Lal, S. K. (2021). The Immunomodulatory CEA Cell Adhesion Molecule 6 (CEACAM6/CD66c) Is a Protein Receptor for the Influenza a Virus. Viruses, 13(5), 726.

Tian, C., Zhang, B., & Ge, C. (2020). Effect of CEACAM6 silencing on the biological behavior of human gallbladder cancer cells. Oncology Letters, 20(3), 2677-2688.

Zhu, R., Ge, J., Ma, J., & Zheng, J. (2019). Carcinoembryonic antigen related cell adhesion molecule 6 promotes the proliferation and migration of renal cancer cells through the ERK/AKT signaling pathway. Translational andrology and urology, 8(5), 457.

Pandey, R., Zhou, M., Islam, S., Chen, B., Barker, N. K., Langlais, P., ... & Mahadevan, D. (2019). Carcinoembryonic antigen cell adhesion molecule 6 (CEACAM6) in Pancreatic Ductal Adenocarcinoma (PDA): An integrative analysis of a novel therapeutic target. Scientific reports, 9(1), 1-14.

Iwabuchi, E., Miki, Y., Onodera, Y., Shibahara, Y., Takagi, K., Suzuki, T., ... & Sasano, H. (2019). Co-expression of carcinoembryonic antigen-related cell adhesion molecule 6 and 8 inhibits proliferation and invasiveness of breast carcinoma cells. Clinical & experimental metastasis, 36(5), 423-432.

Chiang, W. F., Cheng, T. M., Chang, C. C., Pan, S. H., Changou, C. A., Chang, T. H., ... & Wu, M. H. (2018). Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) promotes EGF receptor signaling of oral squamous cell carcinoma metastasis via the complex N-glycosylation. Oncogene, 37(1), 116-127.

Rizeq, B., Zakaria, Z., & Ouhtit, A. (2018). Towards understanding the mechanisms of actions of carcinoembryonic antigen‐related cell adhesion molecule 6 in cancer progression. Cancer science, 109(1), 33-42.

Ru, G. Q., Han, Y., Wang, W., Chen, Y., Wang, H. J., Xu, W. J., ... & Huang, D. (2017). CEACAM6 is a prognostic biomarker and potential therapeutic target for gastric carcinoma. Oncotarget, 8(48), 83673.

Zang, M., Hu, L., Cao, S., Fan, Z., Pang, L., Li, J., ... & Liu, B. (2017). Dual role of carcinoembryonic antigen-related cell adhesion molecule 6 expression in predicting the overall survival of gastric cancer patients. Scientific reports, 7(1), 1-11.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant CEACAM6 protein, hFc Tag (CAT#: V2LY-0526-LY3093)

Human Recombinant CEACAM6 protein, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY3094)

Human Recombinant CEACAM6 protein, His Tag (CAT#: V2LY-0526-LY3095)

Human Recombinant CEACAM6 protein, Biotin Conjugated, His Tag (CAT#: V2LY-0526-LY3096)

Human Recombinant CEACAM6 protein, His Tag-1 (CAT#: V2LY-0526-LY3097)

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Human Recombinant CEACAM6 protein, His Tag-1 (CAT#: V2LY-0526-LY3097)

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Isotype control

For research use only. Not intended for any clinical use.

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