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CEACAM6

This gene encodes a protein that belongs to the carcinoembryonic antigen (CEA) family whose members are glycosyl phosphatidyl inositol (GPI) anchored cell surface glycoproteins. Members of this family play a role in cell adhesion and are widely used as tumor markers in serum immunoassay determinations of carcinoma. This gene affects the sensitivity of tumor cells to adenovirus infection. The protein encoded by this gene acts as a receptor for adherent-invasive E. coli adhesion to the surface of ileal epithelial cells in patients with Crohn's disease. This gene is clustered with genes and pseudogenes of the cell adhesion molecules subgroup of the CEA family on chromosome 19. [provided by RefSeq, Apr 2014]
Full Name
Carcinoembryonic Antigen Related Cell Adhesion Molecule 6
Function
Cell surface glycoprotein that plays a role in cell adhesion and tumor progression (PubMed:2803308, PubMed:2022629, PubMed:1378450, PubMed:8776764, PubMed:11590190, PubMed:10910050, PubMed:14724575, PubMed:16204051).
Intercellular adhesion occurs in a calcium- and fibronectin-independent manner (PubMed:2022629, PubMed:16204051).
Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM5 and CEACAM8 (PubMed:2803308, PubMed:2022629, PubMed:8776764, PubMed:11590190, PubMed:16204051).
Heterophilic interaction with CEACAM8 occurs in activated neutrophils (PubMed:8776764).
Plays a role in neutrophil adhesion to cytokine-activated endothelial cells (PubMed:1378450).
Plays a role as an oncogene by promoting tumor progression; positively regulates cell migration, cell adhesion to endothelial cells and cell invasion (PubMed:16204051).
Also involved in the metastatic cascade process by inducing gain resistance to anoikis of pancreatic adenocarcinoma and colorectal carcinoma cells (PubMed:10910050, PubMed:14724575).
Biological Process
Apoptotic process Source: UniProtKB-KW
Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
Homophilic cell adhesion via plasma membrane adhesion molecules Source: UniProtKB
Leukocyte migration Source: Reactome
Negative regulation of anoikis Source: UniProtKB
Neutrophil degranulation Source: Reactome
Positive regulation of cell migration Source: UniProtKB
Positive regulation of cell population proliferation Source: BHF-UCL
Positive regulation of endothelial cell-matrix adhesion via fibronectin Source: UniProtKB
Positive regulation of heterotypic cell-cell adhesion Source: UniProtKB
Signal transduction Source: UniProtKB
Cellular Location
Cell membrane; Apical cell membrane; Cell surface. Localized to the apical glycocalyx surface.
PTM
Glycosylated.

Anti-CEACAM6 antibodies

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Target: CEACAM6
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBWJC-2456
Application*: F
Target: CEACAM6
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EPR4403
Application*: WB, IP, P, IC
Target: CEACAM6
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0841
Application*: F
Target: CEACAM6
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXC-1192
Application*: F
Target: CEACAM6
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse
Clone: CBXC-2708
Application*: WB, F, E, IH
Target: CEACAM6
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYC-1689
Application*: E, IF, WB
Target: CEACAM6
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse
Clone: CBFYC-0414
Application*: WB, F, E, IH, MC
Target: CEACAM6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-0044
Application*: F
Target: CEACAM6
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBLC288-LY
Application*: WB, IP, P, IC
Target: CEACAM6
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Monkey
Clone: SPM506
Application*: P, IF/IC, C
Target: CEACAM6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: ML02C001
Application*: E, IP, IH, WB
Target: CEACAM6
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: SPM584
Application*: F
Target: CEACAM6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: PARLAM 4
Application*: WB, P, C, IF/IC, C
Target: CEACAM6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C1857
Application*: E, F, IH, WB
Target: CEACAM6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C1856
Application*: E
Target: CEACAM6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C1855
Application*: IF, F
Target: CEACAM6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C1854
Application*: E, F
Target: CEACAM6
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYY-C1853
Application*: E(Det)
Target: CEACAM6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 8B7G4
Application*: E
Target: CEACAM6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5E506
Application*: E, F, C, WB
Target: CEACAM6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5E10C7
Application*: E, F
Target: CEACAM6
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1G2
Application*: E, IF, WB
Target: CEACAM6
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 131-13881 TF3-H8-1-6
Application*: IO
Target: CEACAM6
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 12K256
Application*: E, WB
Target: CEACAM6
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 057-10009
Application*: E
Target: CEACAM6
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 01
Application*: E
Target: CEACAM6
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 439424
Application*: WB, F, MC
Target: CEACAM6
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 408
Application*: WB, E, F, IC/IF, IF
Target: CEACAM6
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse
Clone: 1H7-4B
Application*: WB, F, E, IH, MC
Target: CEACAM6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 12
Application*: F
Target: CEACAM6
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 111
Application*: E
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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