Mouse Anti-CEACAM6 Recombinant Antibody (CBT2231) (V2LY-0625-LY1695)

Name: Mouse Anti-CEACAM6 Recombinant Antibody (CBT2231)
SKU: V2LY-0625-LY1695
Rating: 5 (1 reviews)

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Tested Data

Mouse Anti-CEACAM6 Recombinant Antibody (CBT2231) (V2LY-0625-LY1695) in ELISA

Mouse Anti-CEACAM6 Recombinant Antibody (CBT2231) (V2LY-0625-LY1695) in WB

Mouse Anti-CEACAM6 Recombinant Antibody (CBT2231) (V2LY-0625-LY1695) in IF

Mouse Anti-CEACAM6 Recombinant Antibody (CBT2231) (V2LY-0625-LY1695) in FC

Mouse Anti-CEACAM6 Recombinant Antibody (CBT2231) (V2LY-0625-LY1695) in IHC

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBT2231

Application

WB, IHC, ICC, FC

Immunogen

Purified recombinant fragment of human CEACAM6 (AA: 35-256) expressed in HEK293-6e cells supernatant.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:500-1:2,000
IHC-P	1:200-1:1,000
ICC	1:25-1:100
FC	1:200-1:400
ELISA	1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Carcinoembryonic Antigen Related Cell Adhesion Molecule 6

Entrez Gene ID

4680

UniProt ID

P40199

Function

Cell surface glycoprotein that plays a role in cell adhesion and tumor progression (PubMed:2803308, PubMed:2022629, PubMed:1378450, PubMed:8776764, PubMed:11590190, PubMed:10910050, PubMed:14724575, PubMed:16204051).
Intercellular adhesion occurs in a calcium- and fibronectin-independent manner (PubMed:2022629, PubMed:16204051).
Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM5 and CEACAM8 (PubMed:2803308, PubMed:2022629, PubMed:8776764, PubMed:11590190, PubMed:16204051).
Heterophilic interaction with CEACAM8 ^oCcurs in activated neutrophils (PubMed:8776764).
Plays a role in neutrophil adhesion to cytokine-activated endothelial cells (PubMed:1378450).
Plays a role as an oncogene by promoting tumor progression; positively regulates cell migration, cell adhesion to endothelial cells and cell invasion (PubMed:16204051).
Also involved in the metastatic cascade process by inducing gain resistance to anoikis of pancreatic adenocarcinoma and colorectal carcinoma cells (PubMed:10910050, PubMed:14724575).

Biological Process

Apoptotic process Source: UniProtKB-KW
Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
Homophilic cell adhesion via plasma membrane adhesion molecules Source: UniProtKB
Leukocyte migration Source: Reactome
Negative regulation of anoikis Source: UniProtKB
Neutrophil degranulation Source: Reactome
Positive regulation of cell migration Source: UniProtKB
Positive regulation of cell population proliferation Source: BHF-UCL
Positive regulation of endothelial cell-matrix adhesion via fibronectin Source: UniProtKB
Positive regulation of heterotypic cell-cell adhesion Source: UniProtKB
Signal transduction Source: UniProtKB

Cellular Location

Cell membrane; Apical cell membrane; Cell surface. Localized to the apical glycocalyx surface.

PTM

Glycosylated.

An, F., Zheng, C., Zhang, G., Zhou, L., Wu, Y., Hou, Z., ... & Zhan, Q. (2021). Carcinoembryonic Antigen Related Cell Adhesion Molecule 6 Promotes Carcinogenesis of Gastric Cancer and Anti-CEACAM6 Fluorescent Probe Can Diagnose the Precancerous Lesions. Frontiers in Oncology, 11.

Rahman, S. K., Ansari, M. A., Gaur, P., Ahmad, I., Chakravarty, C., Verma, D. K., ... & Lal, S. K. (2021). The Immunomodulatory CEA Cell Adhesion Molecule 6 (CEACAM6/CD66c) Is a Protein Receptor for the Influenza a Virus. Viruses, 13(5), 726.

Tian, C., Zhang, B., & Ge, C. (2020). Effect of CEACAM6 silencing on the biological behavior of human gallbladder cancer cells. Oncology Letters, 20(3), 2677-2688.

Zhu, R., Ge, J., Ma, J., & Zheng, J. (2019). Carcinoembryonic antigen related cell adhesion molecule 6 promotes the proliferation and migration of renal cancer cells through the ERK/AKT signaling pathway. Translational andrology and urology, 8(5), 457.

Pandey, R., Zhou, M., Islam, S., Chen, B., Barker, N. K., Langlais, P., ... & Mahadevan, D. (2019). Carcinoembryonic antigen cell adhesion molecule 6 (CEACAM6) in Pancreatic Ductal Adenocarcinoma (PDA): An integrative analysis of a novel therapeutic target. Scientific reports, 9(1), 1-14.

Iwabuchi, E., Miki, Y., Onodera, Y., Shibahara, Y., Takagi, K., Suzuki, T., ... & Sasano, H. (2019). Co-expression of carcinoembryonic antigen-related cell adhesion molecule 6 and 8 inhibits proliferation and invasiveness of breast carcinoma cells. Clinical & experimental metastasis, 36(5), 423-432.

Chiang, W. F., Cheng, T. M., Chang, C. C., Pan, S. H., Changou, C. A., Chang, T. H., ... & Wu, M. H. (2018). Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) promotes EGF receptor signaling of oral squamous cell carcinoma metastasis via the complex N-glycosylation. Oncogene, 37(1), 116-127.

Rizeq, B., Zakaria, Z., & Ouhtit, A. (2018). Towards understanding the mechanisms of actions of carcinoembryonic antigen‐related cell adhesion molecule 6 in cancer progression. Cancer science, 109(1), 33-42.

Ru, G. Q., Han, Y., Wang, W., Chen, Y., Wang, H. J., Xu, W. J., ... & Huang, D. (2017). CEACAM6 is a prognostic biomarker and potential therapeutic target for gastric carcinoma. Oncotarget, 8(48), 83673.

Zang, M., Hu, L., Cao, S., Fan, Z., Pang, L., Li, J., ... & Liu, B. (2017). Dual role of carcinoembryonic antigen-related cell adhesion molecule 6 expression in predicting the overall survival of gastric cancer patients. Scientific reports, 7(1), 1-11.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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