Cynomolgus Recombinant EDAR protein, hFc Tag (V2LY-0526-LY1493)

Name: Cynomolgus Recombinant EDAR protein, hFc Tag
SKU: V2LY-0526-LY1493
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Cynomolgus

Tag

hFc Tag

Protein Construction

This product is Cynomolgus Recombinant EDAR protein, hFc Tag consist of Amino Acid: 1-187 and predicts a molecular mass of 44.6 kDa.

Molecule Mass

44.6 kDa

Sequence

Amino Acid: 1-187

Species

Cynomolgus

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>95% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile Tris, NaCl, Glutathione, EDTA, DTT, PMSF, Glycerol

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

ectodysplasin A receptor

Research Area

Receptor for EDA isoform A1, but not for EDA isoform A2. Mediates the activation of NF-kappa-B and JNK. May promote caspase-independent cell death.

Biological Process

Apoptotic process Source: UniProtKB-KW
Cell differentiation Source: UniProtKB-KW
Epidermis development Source: HGNC-UCL
Hair follicle development Source: Ensembl
Odontogenesis of dentin-containing tooth Source: Ensembl
Pigmentation Source: Ensembl
Positive regulation of gene expression Source: Ensembl
Positive regulation of I-kappaB kinase/NF-kappaB signaling Source: GO_Central
Positive regulation of JNK cascade Source: GO_Central
Positive regulation of NIK/NF-kappaB signaling Source: Ensembl
Salivary gland cavitation Source: Ensembl

Cellular Location

Membrane

Involvement in disease

Ectodermal dysplasia 10A, hypohidrotic/hair/nail type, autosomal dominant (ECTD10A):
A form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. It is an autosomal dominant condition characterized by hypotrichosis, abnormal or missing teeth, and hypohidrosis due to the absence of sweat glands.
Ectodermal dysplasia 10B, hypohidrotic/hair/tooth type, autosomal recessive (ECTD10B):
A disorder due to abnormal development of two or more ectodermal structures, and characterized by sparse hair (atrichosis or hypotrichosis), abnormal or missing teeth and the inability to sweat due to the absence of sweat glands.

Topology

Extracellular: 27-187
Helical: 188-208
Cytoplasmic: 209-448

Laurentino, T. G., Boileau, N., Ronco, F., & Berner, D. (2022). The ectodysplasin-A receptor is a candidate gene for lateral plate number variation in stickleback fish. G3, 12(6), jkac077.

Ahmed, H. A., El-Kamah, G. Y., Rabie, E., Mostafa, M. I., Abouzaid, M. R., Hassib, N. F., ... & Sayed, I. S. (2021). Gene Mutations of the Three Ectodysplasin Pathway Key Players (EDA, EDAR, and EDARADD) Account for More than 60% of Egyptian Ectodermal Dysplasia: A Report of Seven Novel Mutations. Genes, 12(9), 1389.

Wang, B., Liang, Y., Chai, X., Chen, S., Ye, Z., Li, R., ... & Zeng, J. (2020). Ectodysplasin A receptor (EDAR) promotes colorectal cancer cell proliferation via regulation of the Wnt/β-catenin signaling pathway. Experimental Cell Research, 395(1), 112170.

Vial, J., Royet, A., Cassier, P., Tortereau, A., Dinvaut, S., Maillet, D., ... & Castets, M. (2019). The Ectodysplasin receptor EDAR acts as a tumor suppressor in melanoma by conditionally inducing cell death. Cell Death & Differentiation, 26(3), 443-454.

Wohlfart, S., & Schneider, H. (2019). Variants of the ectodysplasin A1 receptor gene underlying homozygous cases of autosomal recessive hypohidrotic ectodermal dysplasia. Clinical Genetics, 95(3), 427-432.

Zheng, X. D., Yang, Q. F., Xu, Z. Y., & Yang, D. Q. (2019). Expression patterns of ectodysplasin and ectodysplasin receptor during early dental development in zebrafish. Hua xi kou Qiang yi xue za zhi= Huaxi Kouqiang Yixue Zazhi= West China Journal of Stomatology, 37(4), 355-360.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Cynomolgus Recombinant EDAR protein, His Tag (CAT#: V2LY-0526-LY1494)

Human Recombinant EDAR protein, hFc Tag (CAT#: V2LY-0526-LY3685)

Human Recombinant EDAR protein, His Tag (CAT#: V2LY-0526-LY3686)

Rat Recombinant EDAR protein, hFc Tag (CAT#: V2LY-0526-LY9344)

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Mouse Anti-EDAR (AA 245-391) Recombinant Antibody (CBFYE-0432) (CAT#: CBMAB-E0751-FY)

Cynomolgus Recombinant EDAR protein, His Tag (CAT#: V2LY-0526-LY1494)

Rat Recombinant EDAR protein, hFc Tag (CAT#: V2LY-0526-LY9344)

Mouse Anti-EDAR Recombinant Antibody (CBFYE-0022) (CAT#: V2LY-0425-LY1383)

Rat Anti-EDAR Recombinant Antibody (CBFYE-0428) (CAT#: CBMAB-E0746-FY)

Mouse Anti-EDAR Recombinant Antibody (CBFYE-0432) (CAT#: V2LY-0425-LY1387)

Rat Anti-EDAR Recombinant Antibody (CBFYE-0428) (CAT#: V2LY-0425-LY1385)

Isotype control

For research use only. Not intended for any clinical use.

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