Cynomolgus Recombinant IL18R1 protein, His Tag-1 (V2LY-0526-LY1557)

Name: Cynomolgus Recombinant IL18R1 protein, His Tag-1
SKU: V2LY-0526-LY1557
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Cynomolgus

Tag

His Tag

Protein Construction

This product is Cynomolgus Recombinant IL18R1 protein, His Tag consist of Amino Acid: 1-315 and predicts a molecular mass of 35.6 kDa.

Molecule Mass

35.6 kDa

Verified

HPLC

Sequence

Amino Acid: 1-315

Species

Cynomolgus

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥95% as determined by SDS-PAGE. ≥90% as determined by SEC-HPLC.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

interleukin 18 receptor 1

Function

Within the IL18 receptor complex, responsible for the binding of the proinflammatory cytokine IL18, but not IL1A nor IL1B (PubMed:8626725, PubMed:14528293, PubMed:25261253, PubMed:25500532).

Involved in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (PubMed:10653850).

Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3 (By similarity).

Biological Process

Immune response Source: ProtInc
Inflammatory response Source: UniProtKB-KW
Interleukin-18-mediated signaling pathway Source: UniProtKB
Natural killer cell activation Source: Ensembl
Negative regulation of cold-induced thermogenesis Source: YuBioLab
Positive regulation of interferon-gamma production Source: UniProtKB
Positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
Positive regulation of NIK/NF-kappaB signaling Source: Ensembl
Positive regulation of T-helper 1 cell cytokine production Source: UniProtKB
Signal transduction Source: ProtInc
T-helper 1 cell differentiation Source: Ensembl

Cellular Location

Membrane

Topology

Extracellular: 22-329
Helical: 330-350
Cytoplasmic: 351-541

PTM

N-glycosylated. N-linked glycosyl chains contribute to ligand recognition and intra-receptor interactions required for formation of an active ternary receptor complex.

Zhang, L., Li, M., Wang, Z., Sun, P., Wei, S., Zhang, C., ... & Bai, H. (2022). Cardiovascular risk after SARS-CoV-2 infection is mediated by IL18/IL18R1/HIF-1 signaling pathway axis. Frontiers in Immunology, 12, 780804.

Guo, Q., Wu, C. Y., Jiang, N., Tong, S., Wan, J. H., Xiao, X. Y., ... & Wang, S. H. (2022). Downregulation of T-cell cytotoxic marker IL18R1 promotes cancer proliferation and migration and is associated with dismal prognosis and immunity in lung squamous cell carcinoma. Frontiers in Immunology, 13, 986447.

Marchetti, P., Antonov, A., Anemona, L., Vangapandou, C., Montanaro, M., Botticelli, A., ... & Catani, M. V. (2021). New immunological potential markers for triple negative breast cancer: IL18R1, CD53, TRIM, Jaw1, LTB, PTPRCAP. Discover Oncology, 12(1), 6.

Ponasenko, A. V., Khutornaya, M. V., Malyshev, I. Y., & Barbarash, O. L. (2020). Interleukin 18 levels in patients with stable coronary artery disease is associated with IL18RAP and IL18R1 gene polymorphism and the risk of myocardial infarction. Russian Journal of Cardiology, 25(10), 3977.

Tan, X., Zhou, Q., Lv, M., Tan, H., Wang, Q., Zhang, L., ... & Yang, P. (2020). Functional Genetic Polymorphisms in the IL1RL1–IL18R1 Region Confer Risk for Ocular Behçet’s Disease in a Chinese Han Population. Frontiers in Genetics, 11, 645.

Li, X., Christenson, S. A., Kaminski, N., Wenzel, S. E., Woodruff, P. G., Meyers, D. A., ... & the Severe Asthma Research Program (SARP). (2020). Genetic Analyses Identify IL1R2-IL1RL1-IL18R1 in Chr2q Region Associated with Asthma and COPD. In B94. ADULT AND PEDIATRIC ASTHMA GENETIC STUDIES (pp. A4218-A4218). American Thoracic Society.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Canine Recombinant IL18R1 protein, ECD, His Tag (CAT#: V2LY-0526-LY1274)

Canine Recombinant IL18R1 protein, hFc Tag (CAT#: V2LY-0526-LY1275)

Cynomolgus Recombinant IL18R1 protein, hFc Tag (CAT#: V2LY-0526-LY1555)

Cynomolgus Recombinant IL18R1 protein, His Tag (CAT#: V2LY-0526-LY1556)

Human Recombinant IL18R1 protein, ECD, Biotin Conjugated, hFc & AVI Tag (CAT#: V2LY-0526-LY4797)

Human Recombinant IL18R1 protein, ECD, hFc Tag (CAT#: V2LY-0526-LY4798)

Human Recombinant IL18R1 protein, ECD, Biotin Conjugated, His Tag (CAT#: V2LY-0526-LY4799)

Human Recombinant IL18R1 protein, ECD, His Tag (CAT#: V2LY-0526-LY4800)

Mouse Recombinant IL18R1 protein, ECD, Fc Tag (CAT#: V2LY-0526-LY8502)

Mouse Recombinant IL18R1 protein, His & hFc Tag (CAT#: V2LY-0526-LY8503)

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Human Recombinant IL18R1 protein, ECD, His Tag (CAT#: V2LY-0526-LY4800)

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Human Recombinant IL18R1 protein, ECD, Biotin Conjugated, hFc & AVI Tag (CAT#: V2LY-0526-LY4797)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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