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IL18R1

The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. [provided by RefSeq]
Full Name
interleukin 18 receptor 1
Function
Within the IL18 receptor complex, responsible for the binding of the proinflammatory cytokine IL18, but not IL1A nor IL1B (PubMed:8626725, PubMed:14528293, PubMed:25261253, PubMed:25500532).

Involved in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (PubMed:10653850).

Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3 (By similarity).
Biological Process
Immune response Source: ProtInc
Inflammatory response Source: UniProtKB-KW
Interleukin-18-mediated signaling pathway Source: UniProtKB
Natural killer cell activation Source: Ensembl
Negative regulation of cold-induced thermogenesis Source: YuBioLab
Positive regulation of interferon-gamma production Source: UniProtKB
Positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
Positive regulation of NIK/NF-kappaB signaling Source: Ensembl
Positive regulation of T-helper 1 cell cytokine production Source: UniProtKB
Signal transduction Source: ProtInc
T-helper 1 cell differentiation Source: Ensembl
Cellular Location
Membrane
Topology
Extracellular: 22-329
Helical: 330-350
Cytoplasmic: 351-541
PTM
N-glycosylated. N-linked glycosyl chains contribute to ligand recognition and intra-receptor interactions required for formation of an active ternary receptor complex.
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Anti-IL18R1 antibodies

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Mouse Anti-IL18R1 Recombinant Antibody (CBT3556) (V2LY-0625-LY1256)

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Target: IL18R1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3556
Application*: F
Datasheet SDS

Mouse Anti-IL18R1 Recombinant Antibody (CBWJC-3808) (CBMAB-C5077WJ)

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Target: IL18R1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-3808
Application*: FN
Datasheet SDS

Mouse Anti-IL18R1 Recombinant Antibody (CBXC-0657) (CBMAB-C5350-CQ)

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Target: IL18R1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0657
Application*: F, WB
Datasheet SDS

Mouse Anti-IL18R1 Recombinant Antibody (CBXC-0658) (CBMAB-C3211-CQ)

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Target: IL18R1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBXC-0658
Application*: E
Datasheet SDS

Mouse Anti-IL18R1 Recombinant Antibody (H44) (CBMAB-C1760-CQ)

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Target: IL18R1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: H44
Application*: F
Datasheet SDS

Rat Anti-IL18R1 Recombinant Antibody (CBYY-C2558) (CBMAB-C3999-YY)

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Target: IL18R1
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYY-C2558
Application*: WB
Datasheet SDS

Mouse Anti-IL18R1 (AA 20-329) Recombinant Antibody (CBFYC-2756) (CBMAB-C2831-FY)

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Target: IL18R1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYC-2756
Application*: F
Datasheet SDS

Mouse Anti-IL18R1 Recombinant Antibody (CBYY-I1844) (CBMAB-I3014-YY)

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Target: IL18R1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1844
Application*: F
Datasheet SDS

Mouse Anti-IL18R1 Recombinant Antibody (CBYY-I1386) (CBMAB-I2556-YY)

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Target: IL18R1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1386
Application*: E
Datasheet SDS

Mouse Anti-IL18R1 Recombinant Antibody (CBYY-I1356) (CBMAB-I2526-YY)

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Target: IL18R1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1356
Application*: IH, N, WB
Datasheet SDS

Rat Anti-IL18R1 Recombinant Antibody (CBYY-I1266) (CBMAB-I2435-YY)

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Target: IL18R1
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYY-I1266
Application*: WB
Datasheet SDS

Mouse Anti-IL18R1 Recombinant Antibody (B-E43) (CBMAB-I1994-YY)

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Target: IL18R1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: B-E43
Application*: E, F, FN
Datasheet SDS

Mouse Anti-IL18R1 Recombinant Antibody (70625) (CBMAB-I1601-YY)

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Target: IL18R1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 70625
Application*: F, IH, N, IC, MC, I
Datasheet SDS

Mouse Anti-IL18R1 Recombinant Antibody (CBYY-I0717) (CBMAB-I1600-YY)

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Target: IL18R1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0717
Application*: WB
Datasheet SDS

Mouse Anti-IL18R1 Recombinant Antibody (17) (CBMAB-I0432-YY)

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Target: IL18R1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 17
Application*: F
Datasheet SDS

Mouse Anti-IL18R1 Recombinant Antibody (44G6) (CBMAB-C6499-LY)

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Target: IL18R1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 44G6
Application*: F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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