IL18R1
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. [provided by RefSeq]
Full Name
interleukin 18 receptor 1
Function
Within the IL18 receptor complex, responsible for the binding of the proinflammatory cytokine IL18, but not IL1A nor IL1B (PubMed:8626725, PubMed:14528293, PubMed:25261253, PubMed:25500532).
Involved in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (PubMed:10653850).
Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3 (By similarity).
Involved in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (PubMed:10653850).
Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3 (By similarity).
Biological Process
Immune response Source: ProtInc
Inflammatory response Source: UniProtKB-KW
Interleukin-18-mediated signaling pathway Source: UniProtKB
Natural killer cell activation Source: Ensembl
Negative regulation of cold-induced thermogenesis Source: YuBioLab
Positive regulation of interferon-gamma production Source: UniProtKB
Positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
Positive regulation of NIK/NF-kappaB signaling Source: Ensembl
Positive regulation of T-helper 1 cell cytokine production Source: UniProtKB
Signal transduction Source: ProtInc
T-helper 1 cell differentiation Source: Ensembl
Inflammatory response Source: UniProtKB-KW
Interleukin-18-mediated signaling pathway Source: UniProtKB
Natural killer cell activation Source: Ensembl
Negative regulation of cold-induced thermogenesis Source: YuBioLab
Positive regulation of interferon-gamma production Source: UniProtKB
Positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
Positive regulation of NIK/NF-kappaB signaling Source: Ensembl
Positive regulation of T-helper 1 cell cytokine production Source: UniProtKB
Signal transduction Source: ProtInc
T-helper 1 cell differentiation Source: Ensembl
Cellular Location
Membrane
Topology
Extracellular: 22-329
Helical: 330-350
Cytoplasmic: 351-541
Helical: 330-350
Cytoplasmic: 351-541
PTM
N-glycosylated. N-linked glycosyl chains contribute to ligand recognition and intra-receptor interactions required for formation of an active ternary receptor complex.
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Anti-IL18R1 antibodies
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CompareTarget: Il18r1
Sensitivity: 0.0057 ng/mL
Detection Range: 0.01-2 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
Target: IL18R1
Sensitivity: 0.026 ng/mL
Detection Range: 0.05-20 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: Il18r1
Sensitivity: 0.014 ng/mL
Detection Range: 0.03-9 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
Target: IL18R1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-326
Tag: His Tag
Target: IL18R1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-326
Tag: hFc Tag
Target: IL18R1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-326
Tag: His Tag
Target: IL18R1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-326
Tag: His & hFc Tag
Target: IL18R1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-326
Tag: Fc Tag
Target: IL18R1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-329
Tag: His Tag
Target: IL18R1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-329
Tag: His Tag
Target: IL18R1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-329
Tag: hFc Tag
Target: IL18R1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-329
Tag: hFc & AVI Tag
Target: IL18R1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-315
Tag: His Tag
Target: IL18R1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-315
Tag: His Tag
Target: IL18R1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-315
Tag: hFc Tag
Target: IL18R1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-327
Tag: hFc Tag
Target: IL18R1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-327
Tag: His Tag
Target: IL18R1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3556
Application*: F
Target: IL18R1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-3808
Application*: FN
Target: IL18R1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0657
Application*: F, WB
Target: IL18R1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBXC-0658
Application*: E
Target: IL18R1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: H44
Application*: F
Target: IL18R1
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYY-C2558
Application*: WB
Target: IL18R1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYC-2756
Application*: F
Target: IL18R1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1844
Application*: F
Target: IL18R1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1386
Application*: E
Target: IL18R1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1356
Application*: IH, N, WB
Target: IL18R1
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYY-I1266
Application*: WB
Target: IL18R1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: B-E43
Application*: E, F, FN
Target: IL18R1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 70625
Application*: F, IH, N, IC, MC, I
Target: IL18R1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0717
Application*: WB
Target: IL18R1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 17
Application*: F
Target: IL18R1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 44G6
Application*: F
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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