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Mouse Anti-IL18R1 Recombinant Antibody (70625) (CBMAB-I1601-YY)

This product is Mouse antibody that recognizes IL18R1. The antibody 70625 can be used for immunoassay techniques such as: FC, IHC, Neut, ICC, CyTOF, Inhib
See all IL18R1 antibodies
Published Data
Fig.1 FACS of endothelial cells isolated from Apoe−/− or Apoe−/−Il18r−/− mice after binding with biotin-IL18 with and without an excess of unlabeled IL18.
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Fig.2 p-Tyr detected by immunoblotting in endothelial cells isolated from Apoe−/− or Apoe−/−Il18r−/− mice treated with or without IL18 or heat-inactivated IL18 for 30 min.
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Fig.3 Identification of IL18-binding proteins in endothelial cells from Apoe−/−Il18r−/− mice.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
70625
Antibody Isotype
IgG1
Application
FC, IHC, Neut, ICC, CyTOF, Inhib

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
0.2 μm filtered solution in with Trehalose
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
interleukin 18 receptor 1
Introduction
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
8809
UniProt ID
Q13478
Alternative Names
Interleukin 18 Receptor 1
Function
Within the IL18 receptor complex, responsible for the binding of the proinflammatory cytokine IL18, but not IL1A nor IL1B (PubMed:8626725, PubMed:14528293, PubMed:25261253, PubMed:25500532).

Involved in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (PubMed:10653850).

Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3 (By similarity).
Biological Process
Immune response Source: ProtInc
Inflammatory response Source: UniProtKB-KW
Interleukin-18-mediated signaling pathway Source: UniProtKB
Natural killer cell activation Source: Ensembl
Negative regulation of cold-induced thermogenesis Source: YuBioLab
Positive regulation of interferon-gamma production Source: UniProtKB
Positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
Positive regulation of NIK/NF-kappaB signaling Source: Ensembl
Positive regulation of T-helper 1 cell cytokine production Source: UniProtKB
Signal transduction Source: ProtInc
T-helper 1 cell differentiation Source: Ensembl
Cellular Location
Membrane
Topology
Extracellular: 22-329
Helical: 330-350
Cytoplasmic: 351-541
PTM
N-glycosylated. N-linked glycosyl chains contribute to ligand recognition and intra-receptor interactions required for formation of an active ternary receptor complex.

Zhang, L., Li, M., Wang, Z., Sun, P., Wei, S., Zhang, C., ... & Bai, H. (2022). Cardiovascular risk after SARS-CoV-2 infection is mediated by IL18/IL18R1/HIF-1 signaling pathway axis. Frontiers in Immunology, 12, 780804.

Guo, Q., Wu, C. Y., Jiang, N., Tong, S., Wan, J. H., Xiao, X. Y., ... & Wang, S. H. (2022). Downregulation of T-cell cytotoxic marker IL18R1 promotes cancer proliferation and migration and is associated with dismal prognosis and immunity in lung squamous cell carcinoma. Frontiers in Immunology, 13, 986447.

Marchetti, P., Antonov, A., Anemona, L., Vangapandou, C., Montanaro, M., Botticelli, A., ... & Catani, M. V. (2021). New immunological potential markers for triple negative breast cancer: IL18R1, CD53, TRIM, Jaw1, LTB, PTPRCAP. Discover Oncology, 12(1), 6.

Ponasenko, A. V., Khutornaya, M. V., Malyshev, I. Y., & Barbarash, O. L. (2020). Interleukin 18 levels in patients with stable coronary artery disease is associated with IL18RAP and IL18R1 gene polymorphism and the risk of myocardial infarction. Russian Journal of Cardiology, 25(10), 3977.

Tan, X., Zhou, Q., Lv, M., Tan, H., Wang, Q., Zhang, L., ... & Yang, P. (2020). Functional Genetic Polymorphisms in the IL1RL1–IL18R1 Region Confer Risk for Ocular Behçet’s Disease in a Chinese Han Population. Frontiers in Genetics, 11, 645.

Li, X., Christenson, S. A., Kaminski, N., Wenzel, S. E., Woodruff, P. G., Meyers, D. A., ... & the Severe Asthma Research Program (SARP). (2020). Genetic Analyses Identify IL1R2-IL1RL1-IL18R1 in Chr2q Region Associated with Asthma and COPD. In B94. ADULT AND PEDIATRIC ASTHMA GENETIC STUDIES (pp. A4218-A4218). American Thoracic Society.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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