Human IL18R1 ELISA Kit (V2LY-0626-LY4761)

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Tested Data
Datasheet
SDS
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Basic Information

Sensitivity
0.026 ng/mL
Detection Range
0.05-20 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
62.3 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
interleukin 18 receptor 1
Function
Within the IL18 receptor complex, responsible for the binding of the proinflammatory cytokine IL18, but not IL1A nor IL1B (PubMed:8626725, PubMed:14528293, PubMed:25261253, PubMed:25500532).

Involved in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (PubMed:10653850).

Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3 (By similarity).
Biological Process
Immune response Source: ProtInc
Inflammatory response Source: UniProtKB-KW
Interleukin-18-mediated signaling pathway Source: UniProtKB
Natural killer cell activation Source: Ensembl
Negative regulation of cold-induced thermogenesis Source: YuBioLab
Positive regulation of interferon-gamma production Source: UniProtKB
Positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
Positive regulation of NIK/NF-kappaB signaling Source: Ensembl
Positive regulation of T-helper 1 cell cytokine production Source: UniProtKB
Signal transduction Source: ProtInc
T-helper 1 cell differentiation Source: Ensembl
Cellular Location
Membrane
Topology
Extracellular: 22-329
Helical: 330-350
Cytoplasmic: 351-541
PTM
N-glycosylated. N-linked glycosyl chains contribute to ligand recognition and intra-receptor interactions required for formation of an active ternary receptor complex.

Zhang, L., Li, M., Wang, Z., Sun, P., Wei, S., Zhang, C., ... & Bai, H. (2022). Cardiovascular risk after SARS-CoV-2 infection is mediated by IL18/IL18R1/HIF-1 signaling pathway axis. Frontiers in Immunology, 12, 780804.

Guo, Q., Wu, C. Y., Jiang, N., Tong, S., Wan, J. H., Xiao, X. Y., ... & Wang, S. H. (2022). Downregulation of T-cell cytotoxic marker IL18R1 promotes cancer proliferation and migration and is associated with dismal prognosis and immunity in lung squamous cell carcinoma. Frontiers in Immunology, 13, 986447.

Marchetti, P., Antonov, A., Anemona, L., Vangapandou, C., Montanaro, M., Botticelli, A., ... & Catani, M. V. (2021). New immunological potential markers for triple negative breast cancer: IL18R1, CD53, TRIM, Jaw1, LTB, PTPRCAP. Discover Oncology, 12(1), 6.

Ponasenko, A. V., Khutornaya, M. V., Malyshev, I. Y., & Barbarash, O. L. (2020). Interleukin 18 levels in patients with stable coronary artery disease is associated with IL18RAP and IL18R1 gene polymorphism and the risk of myocardial infarction. Russian Journal of Cardiology, 25(10), 3977.

Tan, X., Zhou, Q., Lv, M., Tan, H., Wang, Q., Zhang, L., ... & Yang, P. (2020). Functional Genetic Polymorphisms in the IL1RL1–IL18R1 Region Confer Risk for Ocular Behçet’s Disease in a Chinese Han Population. Frontiers in Genetics, 11, 645.

Li, X., Christenson, S. A., Kaminski, N., Wenzel, S. E., Woodruff, P. G., Meyers, D. A., ... & the Severe Asthma Research Program (SARP). (2020). Genetic Analyses Identify IL1R2-IL1RL1-IL18R1 in Chr2q Region Associated with Asthma and COPD. In B94. ADULT AND PEDIATRIC ASTHMA GENETIC STUDIES (pp. A4218-A4218). American Thoracic Society.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Canine Recombinant IL18R1 protein, ECD, His Tag (CAT#: V2LY-0526-LY1274)

Canine Recombinant IL18R1 protein, hFc Tag (CAT#: V2LY-0526-LY1275)

Cynomolgus Recombinant IL18R1 protein, hFc Tag (CAT#: V2LY-0526-LY1555)

Cynomolgus Recombinant IL18R1 protein, His Tag (CAT#: V2LY-0526-LY1556)

Cynomolgus Recombinant IL18R1 protein, His Tag-1 (CAT#: V2LY-0526-LY1557)

Human Recombinant IL18R1 protein, ECD, Biotin Conjugated, hFc & AVI Tag (CAT#: V2LY-0526-LY4797)

Human Recombinant IL18R1 protein, ECD, hFc Tag (CAT#: V2LY-0526-LY4798)

Human Recombinant IL18R1 protein, ECD, Biotin Conjugated, His Tag (CAT#: V2LY-0526-LY4799)

Human Recombinant IL18R1 protein, ECD, His Tag (CAT#: V2LY-0526-LY4800)

Mouse Recombinant IL18R1 protein, ECD, Fc Tag (CAT#: V2LY-0526-LY8502)

Related Products

Rat Anti-IL18R1 Recombinant Antibody (CBYY-I1266) (CAT#: CBMAB-I2435-YY)

Rat Anti-IL18R1 Recombinant Antibody (CBYY-C2558) (CAT#: CBMAB-C3999-YY)

Canine Recombinant IL18R1 protein, hFc Tag (CAT#: V2LY-0526-LY1275)

Mouse Recombinant IL18R1 protein, His & hFc Tag (CAT#: V2LY-0526-LY8503)

Cynomolgus Recombinant IL18R1 protein, His Tag-1 (CAT#: V2LY-0526-LY1557)

Mouse Anti-IL18R1 Recombinant Antibody (CBYY-I1386) (CAT#: CBMAB-I2556-YY)

Mouse Recombinant IL18R1 protein, ECD, Fc Tag (CAT#: V2LY-0526-LY8502)

Mouse Anti-IL18R1 Recombinant Antibody (70625) (CAT#: CBMAB-I1601-YY)

Cynomolgus Recombinant IL18R1 protein, His Tag (CAT#: V2LY-0526-LY1556)

Rat Recombinant IL18R1 protein, His Tag (CAT#: V2LY-0526-LY9448)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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