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FADD Matched Antibody Pair (406) (APMAB-406LY)

This antibody pair set can be used for detecting and quantifying protein level of human FADD.
See all FADD antibodies

Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Mouse anti-FADD monoclonal antibody, 100 ug
Detection Antibody
Anti-FADD Rabbit polyclonal antibody, 50 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008]
Alternative Names
Fas Associated Via Death Domain; Fas-Associating Death Domain-Containing Protein; Growth-Inhibiting Gene 3 Protein; Fas-Associating Protein With Death Domain; Fas (TNFRSF6)-Associated Via Death Domain; Mediator Of Receptor-Induced Toxicity;
Entrez Gene ID
8772
UniProt ID
Q13158

He, X., Zhang, L., Hu, L., Liu, S., Xiong, A., Wang, J., ... & Li, G. (2021). PM2. 5 Aggravated OVA-Induced Epithelial Tight Junction Disruption Through Fas Associated via Death Domain-Dependent Apoptosis in Asthmatic Mice. Journal of Asthma and Allergy, 14, 1411.

Xu, Z., Zheng, M., Liu, Y., Zhang, L., Zhang, X., & Bai, R. (2021). Roles of TNF receptor-associated and Fas-associated death domain proteins in the apoptosis of Eimeria tenella host cells. Veterinary Parasitology, 290, 109351.

Zhao, Y., Guo, M., Lv, Z., Zhang, W., Shao, Y., Zhao, X., & Li, C. (2020). Fas-associated death domain (FADD) in sea cucumber (Apostichopus japonicus): Molecular cloning, characterization and pro-apoptotic function analysis. Developmental & Comparative Immunology, 108, 103673.

Hollomon, M. G., Patterson, L., Santiago-O'Farrill, J., Kleinerman, E. S., & Gordon, N. (2020). Knock down of Fas-associated protein with death domain (FADD) sensitizes osteosarcoma to TNFα-induced cell death. Journal of Cancer, 11(7), 1657.

Koutsogiannaki, S., Hou, L., Babazada, H., Okuno, T., Blazon-Brown, N., Soriano, S. G., ... & Yuki, K. (2019). The volatile anesthetic sevoflurane reduces neutrophil apoptosis via Fas death domain–Fas-associated death domain interaction. The FASEB Journal, 33(11), 12668.

Mouasni, S., & Tourneur, L. (2018). FADD at the Crossroads between Cancer and Inflammation. Trends in immunology, 39(12), 1036-1053.

Muhammad, I. F., Borné, Y., Melander, O., Orho-Melander, M., Nilsson, J., Söderholm, M., & Engström, G. (2018). FADD (Fas-associated protein with death domain), caspase-3, and caspase-8 and incidence of ischemic stroke. Stroke, 49(9), 2224-2226.

Peng, M., Wang, Y., Qiang, L., Xu, Y., Li, C., Li, T., ... & Wang, J. (2018). Interleukin-35 inhibits TNF-α-induced osteoclastogenesis and promotes apoptosis via shifting the activation from tnf receptor-associated death domain (TRADD)–TRAF2 to TRADD–Fas-associated death domain by JAK1/STAT1. Frontiers in immunology, 9, 1417.

Hernández-Hernández, E., Miralles, A., Esteban, S., & García-Fuster, M. J. (2018). Repeated treatment with the α2-adrenoceptor agonist UK-14304 improves cognitive performance in middle-age rats: role of hippocampal Fas-associated death domain. Journal of Psychopharmacology, 32(2), 248-255.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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