FAP Matched Antibody Pair (409) (APMAB-409LY)

Name: FAP Matched Antibody Pair (409)
SKU: APMAB-409LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet References Q & As Review & reward Protocols Associated Products

Specifications

ApplIcation

Sandwich ELISA

Specificity

Human

Capture Antibody

Mouse anti-FAP monoclonal antibody, 100 ug

Detection Antibody

Anti-FAP Rabbit polyclonal antibody, 50 ug

Dilutions

10 ng/ml-100 ng/ml

Format

Liquid

Storage

Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.

Introduction

The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]

Alternative Names

Fibroblast Activation Protein Alpha; Seprase; 170 KDa Melanoma Membrane-Bound Gelatinase; Gelatine Degradation Protease FAP; Integral Membrane Serine Protease; Post-Proline Cleaving Enzyme; Surface-Expressed Protease; Dipeptidyl Peptidase FAP; FAPalpha; SIMP;

Entrez Gene ID

2191

UniProt ID

Q12884

More Infomation

Yuan, Z., Hu, H., Zhu, Y., Zhang, W., Fang, Q., Qiao, T., ... & Wang, X. (2021). Colorectal cancer cell intrinsic fibroblast activation protein alpha binds to Enolase1 and activates NF-κB pathway to promote metastasis. Cell death & disease, 12(6), 1-15.

Labiano, S., Roh, V., Godfroid, C., Hiou-Feige, A., Romero, J., Sum, E., ... & Romero, P. (2021). CD40 Agonist Targeted to Fibroblast Activation Protein α Synergizes with Radiotherapy in Murine HPV-Positive Head and Neck TumorsSynergistic Antitumor Effect of Radiotherapy and FAP-CD40 in HNSCC. Clinical Cancer Research, 27(14), 4054-4065.

Juillerat-Jeanneret, L., Tafelmeyer, P., & Golshayan, D. (2021). Regulation of fibroblast activation protein-α expression: focus on intracellular protein interactions. Journal of Medicinal Chemistry, 64(19), 14028-14045.

Bughda, R., Dimou, P., D’Souza, R. R., & Klampatsa, A. (2021). Fibroblast activation protein (FAP)-targeted CAR-T cells: Launching an attack on tumor stroma. ImmunoTargets and Therapy, 10, 313.

Fitzgerald, A. A., & Weiner, L. M. (2020). The role of fibroblast activation protein in health and malignancy. Cancer and Metastasis Reviews, 39(3), 783-803.

Hintz, H. M., Gallant, J. P., Vander Griend, D. J., Coleman, I. M., Nelson, P. S., & LeBeau, A. M. (2020). Imaging Fibroblast Activation Protein Alpha Improves Diagnosis of Metastatic Prostate Cancer with Positron Emission TomographyImaging FAP in Prostate Cancer. Clinical Cancer Research, 26(18), 4882-4891.

Roy, J., Hettiarachchi, S. U., Kaake, M., Mukkamala, R., & Low, P. S. (2020). Design and validation of fibroblast activation protein alpha targeted imaging and therapeutic agents. Theranostics, 10(13), 5778-5789.

Solano-Iturri, J. D., Beitia, M., Errarte, P., Calvete-Candenas, J., Etxezarraga, M. C., Loizate, A., ... & Larrinaga, G. (2020). Altered expression of fibroblast activation protein-α (FAP) in colorectal adenoma-carcinoma sequence and in lymph node and liver metastases. Aging (Albany NY), 12(11), 10337.

Windisch, P., Röhrich, M., Regnery, S., Tonndorf-Martini, E., Held, T., Lang, K., ... & Adeberg, S. (2020). Fibroblast activation protein (FAP) specific PET for advanced target volume delineation in glioblastoma. Radiotherapy and Oncology, 150, 159-163.

Solano-Iturri, J. D., Errarte, P., Etxezarraga, M. C., Echevarria, E., Angulo, J., López, J. I., & Larrinaga, G. (2020). Altered tissue and plasma levels of fibroblast activation protein-α (FAP) in renal tumours. Cancers, 12(11), 3393.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Cynomolgus Recombinant FAP protein, ECD, His Tag (CAT#: V2LY-0526-LY1508)

Human Recombinant FAP protein, ECD, hFc Tag (CAT#: V2LY-0526-LY4018)

Human Recombinant FAP protein, ECD, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY4019)

Human Recombinant FAP protein, ECD, His Tag (CAT#: V2LY-0526-LY4020)

Human Recombinant FAP protein, ECD, His Tag-1 (CAT#: V2LY-0526-LY4021)

Human Recombinant FAP protein, ECD, His Tag-2 (CAT#: V2LY-0526-LY4022)

Human Recombinant FAP protein, Biotin Conjugated, His Tag (CAT#: V2LY-0526-LY4023)

Mouse Recombinant FAP protein, hFc Tag (CAT#: V2LY-0526-LY8296)

Related Products

Mouse Anti-FAP Recombinant Antibody (1E5) (CAT#: V2LY-0825-LY1393)

Rat Anti-FAP Recombinant Antibody (CBXF-2848) (CAT#: V2LY-0825-LY1390)

Mouse Anti-FAP Recombinant Antibody (CBT3860) (CAT#: V2LY-0625-LY1276)

Human Recombinant FAP protein, Biotin Conjugated, His Tag (CAT#: V2LY-0526-LY4023)

Cynomolgus Recombinant FAP protein, ECD, His Tag (CAT#: V2LY-0526-LY1508)

Mouse Anti-FAP Recombinant Antibody (F1924) (CAT#: V2LY-0825-LY1385)

Rabbit Anti-FAP Recombinant Antibody (CBXF-2140) (CAT#: V2LY-0825-LY1383)

Human Recombinant FAP protein, ECD, hFc Tag (CAT#: V2LY-0526-LY4018)

Mouse Anti-FAP Recombinant Antibody (CBXF-0296) (CAT#: V2LY-0825-LY1386)

Human Recombinant FAP protein, ECD, His Tag-1 (CAT#: V2LY-0526-LY4021)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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