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FAP Matched Antibody Pair (409) (APMAB-409LY)

This antibody pair set can be used for detecting and quantifying protein level of human FAP.
See all FAP antibodies

Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Mouse anti-FAP monoclonal antibody, 100 ug
Detection Antibody
Anti-FAP Rabbit polyclonal antibody, 50 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]
Alternative Names
Fibroblast Activation Protein Alpha; Seprase; 170 KDa Melanoma Membrane-Bound Gelatinase; Gelatine Degradation Protease FAP; Integral Membrane Serine Protease; Post-Proline Cleaving Enzyme; Surface-Expressed Protease; Dipeptidyl Peptidase FAP; FAPalpha; SIMP;
Entrez Gene ID
2191
UniProt ID
Q12884

Yuan, Z., Hu, H., Zhu, Y., Zhang, W., Fang, Q., Qiao, T., ... & Wang, X. (2021). Colorectal cancer cell intrinsic fibroblast activation protein alpha binds to Enolase1 and activates NF-κB pathway to promote metastasis. Cell death & disease, 12(6), 1-15.

Labiano, S., Roh, V., Godfroid, C., Hiou-Feige, A., Romero, J., Sum, E., ... & Romero, P. (2021). CD40 Agonist Targeted to Fibroblast Activation Protein α Synergizes with Radiotherapy in Murine HPV-Positive Head and Neck TumorsSynergistic Antitumor Effect of Radiotherapy and FAP-CD40 in HNSCC. Clinical Cancer Research, 27(14), 4054-4065.

Juillerat-Jeanneret, L., Tafelmeyer, P., & Golshayan, D. (2021). Regulation of fibroblast activation protein-α expression: focus on intracellular protein interactions. Journal of Medicinal Chemistry, 64(19), 14028-14045.

Bughda, R., Dimou, P., D’Souza, R. R., & Klampatsa, A. (2021). Fibroblast activation protein (FAP)-targeted CAR-T cells: Launching an attack on tumor stroma. ImmunoTargets and Therapy, 10, 313.

Fitzgerald, A. A., & Weiner, L. M. (2020). The role of fibroblast activation protein in health and malignancy. Cancer and Metastasis Reviews, 39(3), 783-803.

Hintz, H. M., Gallant, J. P., Vander Griend, D. J., Coleman, I. M., Nelson, P. S., & LeBeau, A. M. (2020). Imaging Fibroblast Activation Protein Alpha Improves Diagnosis of Metastatic Prostate Cancer with Positron Emission TomographyImaging FAP in Prostate Cancer. Clinical Cancer Research, 26(18), 4882-4891.

Roy, J., Hettiarachchi, S. U., Kaake, M., Mukkamala, R., & Low, P. S. (2020). Design and validation of fibroblast activation protein alpha targeted imaging and therapeutic agents. Theranostics, 10(13), 5778-5789.

Solano-Iturri, J. D., Beitia, M., Errarte, P., Calvete-Candenas, J., Etxezarraga, M. C., Loizate, A., ... & Larrinaga, G. (2020). Altered expression of fibroblast activation protein-α (FAP) in colorectal adenoma-carcinoma sequence and in lymph node and liver metastases. Aging (Albany NY), 12(11), 10337.

Windisch, P., Röhrich, M., Regnery, S., Tonndorf-Martini, E., Held, T., Lang, K., ... & Adeberg, S. (2020). Fibroblast activation protein (FAP) specific PET for advanced target volume delineation in glioblastoma. Radiotherapy and Oncology, 150, 159-163.

Solano-Iturri, J. D., Errarte, P., Etxezarraga, M. C., Echevarria, E., Angulo, J., López, J. I., & Larrinaga, G. (2020). Altered tissue and plasma levels of fibroblast activation protein-α (FAP) in renal tumours. Cancers, 12(11), 3393.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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