FTL Matched Antibody Pair (455) (APMAB-455LY)

Name: FTL Matched Antibody Pair (455)
SKU: APMAB-455LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet References Q & As Review & reward Protocols Associated Products

Specifications

ApplIcation

Sandwich ELISA

Specificity

Human

Capture Antibody

Mouse anti-FTL monoclonal, IgG1 antibody, 100 ug

Detection Antibody

Anti-FTL Biotinylated mouse monoclonal, IgG1 antibody, 50 ug

Dilutions

10 ng/ml-100 ng/ml

Format

Liquid

Storage

Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.

Introduction

This gene encodes the light subunit of the ferritin protein. Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. This gene has multiple pseudogenes. [provided by RefSeq, Jul 2008]

Alternative Names

Ferritin Light Chain; Ferritin L Subunit; Ferritin Light Polypeptide-Like 3; Ferritin, Light Polypeptide; Ferritin L-Chain; Neurodegeneration With Brain Iron Accumulation 3; L Apoferritin; NBIA3; LFTD;

Entrez Gene ID

2512

UniProt ID

P02792

More Infomation

Yang, X., Ding, Y., Sun, L., Shi, M., Zhang, P., Huang, Z., ... & Li, R. (2022). Ferritin light chain deficiency-induced ferroptosis is involved in preeclampsia pathophysiology by disturbing uterine spiral artery remodelling. Redox Biology, 58, 102555.

Kurzawa‐Akanbi, M., Keogh, M., Tsefou, E., Ramsay, L., Johnson, M., Keers, S., ... & Morris, C. M. (2021). Neuropathological and biochemical investigation of Hereditary Ferritinopathy cases with ferritin light chain mutation: Prominent protein aggregation in the absence of major mitochondrial or oxidative stress. Neuropathology and Applied Neurobiology, 47(1), 26-42.

Wang, Y., Qiu, S., Wang, H., Cui, J., Tian, X., Miao, Y., ... & Zhang, X. (2021). Transcriptional repression of ferritin light chain increases ferroptosis sensitivity in lung adenocarcinoma. Frontiers in Cell and Developmental Biology, 9, 719187.

Hao, S., Zhang, Y., Hua, L., Xie, N., Xiao, N., Wang, H., ... & Shao, Z. (2020). Antibodies specific to ferritin light chain polypeptide are frequently detected in patients with immune‑related pancytopenia. Molecular Medicine Reports, 22(3), 2012-2020.

Liu, J., Gao, L., Zhan, N., Xu, P., Yang, J. A., Yuan, F. E., ... & Chen, Q. (2020). Hypoxia induced ferritin light chain (FTL) promoted epithelia mesenchymal transition and chemoresistance of glioma. Journal of Experimental & Clinical Cancer Research, 39, 1-17.

Li, Z., Liu, J., Chen, H., Zhang, Y., Shi, H., Huang, L., ... & Wang, T. (2020). Ferritin Light Chain (FTL) competes with long noncoding RNA Linc00467 for miR-133b binding site to regulate chemoresistance and metastasis of colorectal cancer. Carcinogenesis, 41(4), 467-477.

Pulos-Holmes, M. C., Srole, D. N., Juarez, M. G., Lee, A. S., McSwiggen, D. T., Ingolia, N. T., & Cate, J. H. (2019). Repression of ferritin light chain translation by human eIF3. Elife, 8, e48193.

Bertoli, S., Paubelle, E., Bérard, E., Saland, E., Thomas, X., Tavitian, S., ... & Récher, C. (2019). Ferritin heavy/light chain (FTH1/FTL) expression, serum ferritin levels, and their functional as well as prognostic roles in acute myeloid leukemia. European journal of haematology, 102(2), 131-142.

Zarjou, A., Black, L. M., McCullough, K. R., Hull, T. D., Esman, S. K., Boddu, R., ... & Bolisetty, S. (2019). Ferritin light chain confers protection against sepsis-induced inflammation and organ injury. Frontiers in immunology, 10, 131.

Yu, G. H., Fu, L., Chen, J., Wei, F., & Shi, W. X. (2018). Decreased expression of ferritin light chain in osteosarcoma and its correlation with epithelial-mesenchymal transition. Eur Rev Med Pharmacol Sci, 22(9), 2580-2587.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Alternative Versions

FTL Matched Antibody Pair (453) (CAT#: APMAB-453LY)

FTL Matched Antibody Pair (454) (CAT#: APMAB-454LY)

Antibody Pairs

FTL Matched Antibody Pair (453) (CAT#: APMAB-453LY)

FTL Matched Antibody Pair (454) (CAT#: APMAB-454LY)

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Isotype control

For research use only. Not intended for any clinical use.

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