FTL
This gene encodes the light subunit of the ferritin protein. Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. This gene has multiple pseudogenes. [provided by RefSeq, Jul 2008]
Full Name
Ferritin Light Chain
Function
Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).
Biological Process
Cellular iron ion homeostasis Source: ProtInc
Intracellular sequestering of iron ion Source: GO_Central
Iron ion homeostasis Source: UniProtKB
Iron ion transport Source: InterPro
Intracellular sequestering of iron ion Source: GO_Central
Iron ion homeostasis Source: UniProtKB
Iron ion transport Source: InterPro
Cellular Location
Cytosol; Extracellular exosome; Extracellular region; Autolysosome; Azurophil granule lumen; Cytoplasm; Intracellular ferritin complex; Membrane
Involvement in disease
Hyperferritinemia with or without cataract (HRFTC):
An autosomal dominant disease characterized by elevated level of ferritin in serum and tissues, and early-onset bilateral cataract. Cataracts may be subclinical in some patients.
Neurodegeneration with brain iron accumulation 3 (NBIA3):
A neurodegenerative disorder associated with iron accumulation in the brain, primarily in the basal ganglia. It is characterized by a variety of neurological signs including parkinsonism, ataxia, corticospinal signs, mild non-progressive cognitive deficit and episodic psychosis. It is linked with decreased serum ferritin levels.
L-ferritin deficiency (LFTD):
A condition characterized by low levels of ferritin in serum and tissues in the absence of other hematological symptoms. Seizures and mild neuropsychologic impairment may manifest in individuals with complete ferritin deficiency.
An autosomal dominant disease characterized by elevated level of ferritin in serum and tissues, and early-onset bilateral cataract. Cataracts may be subclinical in some patients.
Neurodegeneration with brain iron accumulation 3 (NBIA3):
A neurodegenerative disorder associated with iron accumulation in the brain, primarily in the basal ganglia. It is characterized by a variety of neurological signs including parkinsonism, ataxia, corticospinal signs, mild non-progressive cognitive deficit and episodic psychosis. It is linked with decreased serum ferritin levels.
L-ferritin deficiency (LFTD):
A condition characterized by low levels of ferritin in serum and tissues in the absence of other hematological symptoms. Seizures and mild neuropsychologic impairment may manifest in individuals with complete ferritin deficiency.
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Anti-FTL antibodies
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CompareTarget: FTL
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1C14
Application*: WB, E
Target: FTL
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 211
Application*: WB, IH
Target: FTL
Sensitivity: 5.18 ng/mL
Detection Range: 10-2000 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Dog
Assay Type: Sandwich
Reactivity: Dog
Target: FTL
Sensitivity: 0.031 ng/mL
Detection Range: 0.3-90 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: FTL
Sensitivity: 1.14 ng/mL
Detection Range: 3-900 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Horse
Assay Type: Sandwich
Reactivity: Horse
Target: FTL
Expressed Host: E. coli
Sequence: Amino Acid: 1-175
Tag: His Tag
Target: FTL
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 12D12
Application*: E, IH, F
Target: FTL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3101
Application*: WB, IH, F
Target: FTL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3305
Application*: WB, IH, IC
Target: FTL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CAP797
Application*: E
Target: FTL
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CB326A
Application*: WB, IP, IF, E
Target: FTL
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1B4-B9
Application*: E
Target: FTL
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1A2C5
Application*: E, IH
Target: FTL
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXF-1637
Application*: WB, IP, IF, E, P
Target: FTL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-1429
Application*: E
Target: FTL
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-3226
Application*: WB
Target: FTL
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBXF-3225
Application*: E, WB
Target: FTL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-3223
Application*: E, WB, IF, IH
Target: FTL
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-3219
Application*: E, IF, IP, WB
Target: FTL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-3218
Application*: E, WB, IF, IH
Target: FTL
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXF-0949
Application*: IP, IR, SE, WB, IF, WB, E
Target: FTL
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBXF-1215
Application*: WB, IP, F
Target: FTL
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-0036
Application*: E, WB
Target: FTL
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 214
Application*: WB, P
Target: FTL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-2487
Application*: E
Target: FTL
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBXF-2033
Application*: WB, P, IP
Target: FTL
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXF-1383
Application*: E, IP, R
Target: FTL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-3884
Application*: E, IP, R
Target: FTL
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: F23
Application*: WB, IH, E
Target: FTL
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXF-1361
Application*: E
Target: FTL
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-0948
Application*: WB, IC, P, C, E
Target: FTL
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXF-3509
Application*: E, WB, P
Target: FTL
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 210
Application*: WB, IH
Target: FTL
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBXF-1214
Application*: WB, IP, IC
Target: FTL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-0034
Application*: E
Target: FTL
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: BA0285
Application*: WB, IP, F
Target: FTL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: AF7B7
Application*: WB
Target: FTL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 8E1E7
Application*: IF, P, WB
Target: FTL
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: BA0284
Application*: IC, IP, WB
Target: FTL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: FTL/1389
Application*: P
Target: FTL
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: FTL/1388
Application*: P
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(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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