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FTL

This gene encodes the light subunit of the ferritin protein. Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. This gene has multiple pseudogenes. [provided by RefSeq, Jul 2008]

Full Name

Ferritin Light Chain

Function

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).

Biological Process

Cellular iron ion homeostasis Source: ProtInc
Intracellular sequestering of iron ion Source: GO_Central
Iron ion homeostasis Source: UniProtKB
Iron ion transport Source: InterPro

Cellular Location

Cytosol; Extracellular exosome; Extracellular region; Autolysosome; Azurophil granule lumen; Cytoplasm; Intracellular ferritin complex; Membrane

Involvement in disease

Hyperferritinemia with or without cataract (HRFTC):
An autosomal dominant disease characterized by elevated level of ferritin in serum and tissues, and early-onset bilateral cataract. Cataracts may be subclinical in some patients.
Neurodegeneration with brain iron accumulation 3 (NBIA3):
A neurodegenerative disorder associated with iron accumulation in the brain, primarily in the basal ganglia. It is characterized by a variety of neurological signs including parkinsonism, ataxia, corticospinal signs, mild non-progressive cognitive deficit and episodic psychosis. It is linked with decreased serum ferritin levels.
L-ferritin deficiency (LFTD):
A condition characterized by low levels of ferritin in serum and tissues in the absence of other hematological symptoms. Seizures and mild neuropsychologic impairment may manifest in individuals with complete ferritin deficiency.

Anti-FTL antibodies

Rabbit Anti-FTL Recombinant Antibody (BA0285) (CBMAB-0318CQ)

SDS

Target: FTL

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: BA0285

Application*: WB, IP, F

Mouse Anti-FTL Recombinant Antibody (AF7B7) (CBMAB-0317CQ)

SDS

Target: FTL

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: AF7B7

Application*: WB

Mouse Anti-FTL Recombinant Antibody (8E1E7) (CBMAB-0316CQ)

SDS

Target: FTL

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 8E1E7

Application*: IF, P, WB

Rabbit Anti-FTL Recombinant Antibody (BA0284) (CBMAB-0315CQ)

SDS

Target: FTL

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: BA0284

Application*: IC, IP, WB

Mouse Anti-FTL Recombinant Antibody (FTL/1389) (CBMAB-0314CQ)

SDS

Target: FTL

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: FTL/1389

Application*: P

Mouse Anti-FTL Recombinant Antibody (FTL/1388) (CBMAB-0313CQ)

SDS

Target: FTL

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: FTL/1388

Application*: P

Mouse Anti-FTL Recombinant Antibody (CBXF-1637) (CBMAB-F4150-CQ)

SDS

Target: FTL

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBXF-1637

Application*: E, IC, IH, WB

Mouse Anti-FTL Recombinant Antibody (CBXF-3226) (CBMAB-F3921-CQ)

SDS

Target: FTL

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBXF-3226

Application*: WB

Mouse Anti-FTL Recombinant Antibody (CBXF-3225) (CBMAB-F3920-CQ)

SDS

Target: FTL

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBXF-3225

Application*: E, WB

Mouse Anti-FTL Recombinant Antibody (CBXF-3223) (CBMAB-F3918-CQ)

SDS

Target: FTL

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBXF-3223

Application*: E, IP

Mouse Anti-FTL Recombinant Antibody (CBXF-3219) (CBMAB-F3914-CQ)

SDS

Target: FTL

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBXF-3219

Application*: E, IF, IP, WB

Mouse Anti-FTL Recombinant Antibody (CBXF-3218) (CBMAB-F3913-CQ)

SDS

Target: FTL

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBXF-3218

Application*: E, IF

Mouse Anti-FTL Recombinant Antibody (CBXF-0949) (CBMAB-F3217-CQ)

SDS

Target: FTL

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBXF-0949

Application*: IP, IR, SE, WB, IF, WB, E

Rabbit Anti-FTL Recombinant Antibody (CBXF-1215) (CBMAB-F2953-CQ)

SDS

Target: FTL

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CBXF-1215

Application*: WB, IP, F

Mouse Anti-FTL Recombinant Antibody (CBXF-0036) (CBMAB-F2494-CQ)

SDS

Target: FTL

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBXF-0036

Application*: E, WB

Mouse Anti-FTL Recombinant Antibody (513C10) (CBMAB-F1956-CQ)

SDS

Target: FTL

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 513C10

Application*: E, IF, IP, R

Mouse Anti-FTL Recombinant Antibody (CBXF-2487) (CBMAB-F1877-CQ)

SDS

Target: FTL

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXF-2487

Application*: E

Mouse Anti-FTL Recombinant Antibody (CBXF-2033) (CBMAB-F1867-CQ)

SDS

Target: FTL

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXF-2033

Application*: E, WB, P, IF, F

Mouse Anti-FTL Recombinant Antibody (CBXF-1383) (CBMAB-F1750-CQ)

SDS

Target: FTL

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBXF-1383

Application*: E, IP, R

Mouse Anti-FTL Recombinant Antibody (CBXF-3884) (CBMAB-F1749-CQ)

SDS

Target: FTL

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXF-3884

Application*: E, IP, R

Mouse Anti-FTL Recombinant Antibody (F23) (CBMAB-F1746-CQ)

SDS

Target: FTL

Host: Mouse

Antibody Isotype: IgG3

Specificity: Human

Clone: F23

Application*: E, IF, SE

Mouse Anti-FTL Recombinant Antibody (CBXF-1361) (CBMAB-F1693-CQ)

SDS

Target: FTL

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBXF-1361

Application*: E

Mouse Anti-FTL Recombinant Antibody (CBXF-0948) (CBMAB-F1460-CQ)

SDS

Target: FTL

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBXF-0948

Application*: WB, IC, P, C, E

Mouse Anti-FTL Recombinant Antibody (CBXF-3509) (CBMAB-F1319-CQ)

SDS

Target: FTL

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBXF-3509

Application*: E, WB, P

Mouse Anti-FTL (AA 38-165) Recombinant Antibody (FTLC1-1) (CBMAB-F1300-CQ)

SDS

Target: FTL

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: FTLC1-1

Application*: WB, P, IF, F

Mouse Anti-FTL Recombinant Antibody (6E10E4) (CBMAB-F1051-CQ)

SDS

Target: FTL

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 6E10E4

Application*: WB, P, F

Rabbit Anti-FTL Recombinant Antibody (CBXF-1214) (CBMAB-F0987-CQ)

SDS

Target: FTL

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CBXF-1214

Application*: WB, IP, IC

Mouse Anti-FTL Recombinant Antibody (CBXF-0034) (CBMAB-F0398-CQ)

SDS

Target: FTL

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXF-0034

Application*: E

Mouse Anti-FTL Recombinant Antibody (CAP797) (CBMAB-AP2404LY)

SDS

Target: FTL

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CAP797

Application*: ELISA, IHC

Mouse Anti-FTL Recombinant Antibody (CB326A) (CBMAB-CA326LY)

SDS

Target: FTL

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CB326A

Application*: ELISA, IHC

Mouse Anti-FTL Recombinant Antibody (1C14) (CBMAB-A3202-LY)

SDS

Target: FTL

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 1C14

Application*: WB, E

Mouse Anti-FTL Recombinant Antibody (1B4-B9) (CBMAB-Z0195-LY)

SDS

Target: FTL

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 1B4-B9

Application*: E

Mouse Anti-FTL Recombinant Antibody (1A2C5) (CBMAB-R4237-CN)

SDS

Target: FTL

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 1A2C5

Application*: E, IH

Mouse Anti-FTL Recombinant Antibody (CBXF-1429) (CBMAB-F4148-CQ)

SDS

Target: FTL

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXF-1429

Application*: E

FTL Matched Antibody Pair (455) (APMAB-455LY)

SDS

Target: FTL

Specificity: Human

FTL Matched Antibody Pair (454) (APMAB-454LY)

SDS

Target: FTL

Specificity: Human

FTL Matched Antibody Pair (453) (APMAB-453LY)

SDS

Target: FTL

Specificity: Human

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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