Mouse Anti-FTL Recombinant Antibody (513C10) (CBMAB-F1956-CQ)

Name: Mouse Anti-FTL Recombinant Antibody (513C10)
SKU: CBMAB-F1956-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

513C10

Application

ELISA, IF, IP, RIA

Immunogen

Human liver ferritin

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

0.01 M potassium phosphate, 0.135M NaCl, 1mg/ml BSA, 2.5mM KCl

Preservative

0.05% sodium azide

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Ferritin Light Chain

Introduction

This gene encodes the light subunit of the ferritin protein. Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. This gene has multiple pseudogenes.

Entrez Gene ID

2512

UniProt ID

P02792

Alternative Names

Ferritin Light Chain; Ferritin L Subunit; Ferritin Light Polypeptide-Like 3; Ferritin, Light Polypeptide; Ferritin L-Chain; Neurodegeneration With Brain Iron Accumulation 3; L Apoferritin; NBIA3; LFTD;

Function

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).

Biological Process

Cellular iron ion homeostasis Source: ProtInc
Intracellular sequestering of iron ion Source: GO_Central
Iron ion homeostasis Source: UniProtKB
Iron ion transport Source: InterPro

Cellular Location

Cytosol; Extracellular exosome; Extracellular region; Autolysosome; Azurophil granule lumen; Cytoplasm; Intracellular ferritin complex; Membrane

Involvement in disease

Hyperferritinemia with or without cataract (HRFTC):
An autosomal dominant disease characterized by elevated level of ferritin in serum and tissues, and early-onset bilateral cataract. Cataracts may be subclinical in some patients.
Neurodegeneration with brain iron accumulation 3 (NBIA3):
A neurodegenerative disorder associated with iron accumulation in the brain, primarily in the basal ganglia. It is characterized by a variety of neurological signs including parkinsonism, ataxia, corticospinal signs, mild non-progressive cognitive deficit and episodic psychosis. It is linked with decreased serum ferritin levels.
L-ferritin deficiency (LFTD):
A condition characterized by low levels of ferritin in serum and tissues in the absence of other hematological symptoms. Seizures and mild neuropsychologic impairment may manifest in individuals with complete ferritin deficiency.

Yang, X., Ding, Y., Sun, L., Shi, M., Zhang, P., Huang, Z., ... & Li, R. (2022). Ferritin light chain deficiency-induced ferroptosis is involved in preeclampsia pathophysiology by disturbing uterine spiral artery remodelling. Redox Biology, 58, 102555.

Kurzawa‐Akanbi, M., Keogh, M., Tsefou, E., Ramsay, L., Johnson, M., Keers, S., ... & Morris, C. M. (2021). Neuropathological and biochemical investigation of Hereditary Ferritinopathy cases with ferritin light chain mutation: Prominent protein aggregation in the absence of major mitochondrial or oxidative stress. Neuropathology and Applied Neurobiology, 47(1), 26-42.

Wang, Y., Qiu, S., Wang, H., Cui, J., Tian, X., Miao, Y., ... & Zhang, X. (2021). Transcriptional repression of ferritin light chain increases ferroptosis sensitivity in lung adenocarcinoma. Frontiers in Cell and Developmental Biology, 9, 719187.

Hao, S., Zhang, Y., Hua, L., Xie, N., Xiao, N., Wang, H., ... & Shao, Z. (2020). Antibodies specific to ferritin light chain polypeptide are frequently detected in patients with immune‑related pancytopenia. Molecular Medicine Reports, 22(3), 2012-2020.

Liu, J., Gao, L., Zhan, N., Xu, P., Yang, J. A., Yuan, F. E., ... & Chen, Q. (2020). Hypoxia induced ferritin light chain (FTL) promoted epithelia mesenchymal transition and chemoresistance of glioma. Journal of Experimental & Clinical Cancer Research, 39, 1-17.

Li, Z., Liu, J., Chen, H., Zhang, Y., Shi, H., Huang, L., ... & Wang, T. (2020). Ferritin Light Chain (FTL) competes with long noncoding RNA Linc00467 for miR-133b binding site to regulate chemoresistance and metastasis of colorectal cancer. Carcinogenesis, 41(4), 467-477.

Pulos-Holmes, M. C., Srole, D. N., Juarez, M. G., Lee, A. S., McSwiggen, D. T., Ingolia, N. T., & Cate, J. H. (2019). Repression of ferritin light chain translation by human eIF3. Elife, 8, e48193.

Bertoli, S., Paubelle, E., Bérard, E., Saland, E., Thomas, X., Tavitian, S., ... & Récher, C. (2019). Ferritin heavy/light chain (FTH1/FTL) expression, serum ferritin levels, and their functional as well as prognostic roles in acute myeloid leukemia. European journal of haematology, 102(2), 131-142.

Zarjou, A., Black, L. M., McCullough, K. R., Hull, T. D., Esman, S. K., Boddu, R., ... & Bolisetty, S. (2019). Ferritin light chain confers protection against sepsis-induced inflammation and organ injury. Frontiers in immunology, 10, 131.

Yu, G. H., Fu, L., Chen, J., Wei, F., & Shi, W. X. (2018). Decreased expression of ferritin light chain in osteosarcoma and its correlation with epithelial-mesenchymal transition. Eur Rev Med Pharmacol Sci, 22(9), 2580-2587.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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FTL Matched Antibody Pair (454) (CAT#: APMAB-454LY)

FTL Matched Antibody Pair (455) (CAT#: APMAB-455LY)

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For research use only. Not intended for any clinical use.

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