GSDMD Matched Antibody Pair (504) (APMAB-504LY)

Name: GSDMD Matched Antibody Pair (504)
SKU: APMAB-504LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet References Q & As Review & reward Protocols Associated Products

Specifications

ApplIcation

Sandwich ELISA

Specificity

Human

Capture Antibody

Rabbit anti-GSDMD polyclonal antibody, 100 ug

Detection Antibody

Anti-GSDMD Mouse monoclonal, IgG1 antibody, 20 ug

Dilutions

10 ng/ml-100 ng/ml

Format

Liquid

Storage

Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.

Introduction

Gasdermin D is a member of the gasdermin family. Members of this family appear to play a role in regulation of epithelial proliferation. Gasdermin D has been suggested to act as a tumor suppressor. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009]

Alternative Names

Gasdermin D; Gasdermin Domain-Containing Protein 1; Gasdermin Domain Containing 1; GSDMDC1; DFNA5L; Gasdermin-D; FKSG10; DF5L;

Entrez Gene ID

79792

UniProt ID

P57764

More Infomation

Xie, W. J., Xia, S., Warshel, A., & Wu, H. (2022). Electrostatic influence on IL-1 transport through the GSDMD pore. Proceedings of the National Academy of Sciences, 119(6), e2120287119.

Liu, Y., Xue, N., Zhang, B., Lv, H., & Li, S. (2022). Cold Stress Induced Liver Injury of Mice through Activated NLRP3/Caspase-1/GSDMD Pyroptosis Signaling Pathway. Biomolecules, 12(7), 927.

Jiang, S., Zhang, H., Li, X., Yi, B., Huang, L., Hu, Z., ... & Zhang, W. (2021). Vitamin D/VDR attenuate cisplatin-induced AKI by down-regulating NLRP3/Caspase-1/GSDMD pyroptosis pathway. The Journal of Steroid Biochemistry and Molecular Biology, 206, 105789.

Zhang, J., Dai, Y., Yang, Y., & Xu, J. (2021). Calcitriol alleviates hyperosmotic stress-induced corneal epithelial cell damage via inhibiting the NLRP3–ASC–caspase-1–GSDMD pyroptosis pathway in dry eye disease. Journal of Inflammation Research, 14, 2955.

Yan, H., Luo, B., Wu, X., Guan, F., Yu, X., Zhao, L., ... & Yuan, J. (2021). Cisplatin induces pyroptosis via activation of MEG3/NLRP3/caspase-1/GSDMD pathway in triple-negative breast cancer. International Journal of Biological Sciences, 17(10), 2606.

Li, W., Deng, M., Loughran, P. A., Yang, M., Lin, M., Yang, C., ... & Scott, M. J. (2020). LPS induces active HMGB1 release from hepatocytes into exosomes through the coordinated activities of TLR4 and caspase-11/GSDMD signaling. Frontiers in Immunology, 11, 229.

Yang, Y., Liu, P. Y., Bao, W., Chen, S. J., Wu, F. S., & Zhu, P. Y. (2020). Hydrogen inhibits endometrial cancer growth via a ROS/NLRP3/caspase-1/GSDMD-mediated pyroptotic pathway. BMC cancer, 20, 1-19.

Schwarzer, R., Jiao, H., Wachsmuth, L., Tresch, A., & Pasparakis, M. (2020). FADD and caspase-8 regulate gut homeostasis and inflammation by controlling MLKL-and GSDMD-mediated death of intestinal epithelial cells. Immunity, 52(6), 978-993.

Karmakar, M., Minns, M., Greenberg, E. N., Diaz-Aponte, J., Pestonjamasp, K., Johnson, J. L., ... & Pearlman, E. (2020). N-GSDMD trafficking to neutrophil organelles facilitates IL-1β release independently of plasma membrane pores and pyroptosis. Nature communications, 11(1), 2212.

Pandeya, A., Li, L., Li, Z., & Wei, Y. (2019). Gasdermin D (GSDMD) as a new target for the treatment of infection. Medchemcomm, 10(5), 660-667.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human GSDMD ELISA Kit (CAT#: V2LY-0626-LY5691)

GSDMD Matched Antibody Pair (505) (CAT#: APMAB-505LY)

Antibody Pairs

GSDMD Matched Antibody Pair (505) (CAT#: APMAB-505LY)

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Mouse Anti-GSDMD Recombinant Antibody (4F11) (CAT#: V2LY-0226-LY1475)

Rat Anti-GSDMD Recombinant Antibody (G5117) (CAT#: V2LY-0226-LY1473)

Mouse Anti-GSDMD Recombinant Antibody (AP2619) (CAT#: V2LY-0226-LY1490)

GSDMD Matched Antibody Pair (505) (CAT#: APMAB-505LY)

Rabbit Anti-GSDMD Recombinant Antibody (CBLG1-245) (CAT#: V2LY-0226-LY1489)

Mouse Anti-GSDMD Recombinant Antibody (CBLG1-1823) (CAT#: V2LY-0226-LY1478)

Human GSDMD ELISA Kit (CAT#: V2LY-0626-LY5691)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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