Human C1QC ELISA Kit (V2LY-0626-LY4424)

Name: Human C1QC ELISA Kit
SKU: V2LY-0626-LY4424
Rating: 5 (1 reviews)

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Tested Data

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity

2.49 ng/mL

Detection Range

5-1000 ng/mL

Sample Type

Serum, Plasma, cell culture supernates

Specificity

Human

Assay Type

Sandwich

Reactivity

Human

Assay Time

1.5 h

Molecule Mass

25.8 kDa

Components

Pre-coated ELISA Plate: 12 wells * 8 detachable strips
Standard solution: 0.5ml x1
Standard diluent: 3ml x1
Streptavidin-HRP: 6ml x1
Stop solution: 6ml x1
Substrate solution A: 6ml x1
Substrate solution B: 6ml x1
Wash buffer concentrate (25x): 20ml x1
Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 2-8°C

More Infomation

Target

Full Name

complement C1q C chain

Function

C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca2+-dependent C1r2C1s2 proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.

Biological Process

Complement activation Source: Reactome
Complement activation, classical pathway Source: Reactome
Immune response Source: UniProtKB
Innate immune response Source: UniProtKB-KW
Negative regulation of granulocyte differentiation Source: BHF-UCL
Negative regulation of macrophage differentiation Source: BHF-UCL
Regulation of complement activation Source: Reactome
Synapse pruning Source: ARUK-UCL

Cellular Location

Secreted

Involvement in disease

Complement component C1q deficiency (C1QD): A disorder caused by impaired activation of the complement classical pathway. It generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.

PTM

O-linked glycans consist of Glc-Gal disaccharides bound to the oxygen atom of post-translationally added hydroxyl groups.

Chen, L. H., Liu, J. F., Lu, Y., He, X. Y., Zhang, C., & Zhou, H. H. (2021). Complement C1q (C1qA, C1qB, and C1qC) May Be a Potential Prognostic Factor and an Index of Tumor Microenvironment Remodeling in Osteosarcoma. Frontiers in oncology, 11, 1643.

Mamoor, S. (2021). Chain A, B, and C of the complement component C1q are differentially expressed in human epithelial ovarian cancer.

Kumar, A., Chawla, K., Madigubba, H., Thakur, R., & Bisht, D. (2019). Evaluation of Serum Complement Component 1Q Subcomponent C (C1qC) as a Marker for Tuberculosis. Journal of Evolution of Medical and Dental Sciences, 8(33), 2624-2629.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Mouse Anti-C1QC Recombinant Antibody (3R9/2) (CAT#: CBMAB-C6404-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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