Human CLDN12 ELISA Kit (V2LY-0626-LY2793)

Go to compare Compare Online Inquiry
Tested Data
Request for COA
Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
0.0081 ng/mL
Detection Range
0.015-3 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
27.1 kDa
Components
  • Pre-coated ELISA plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
claudin 12
Function
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
Biological Process
Calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules Source: UniProtKB
Maintenance of blood-brain barrier Source: ARUK-UCL
Cellular Location
Cell membrane; Tight junction
Topology
Cytoplasmic: 1-10
Helical: 11-31
Extracellular: 32-87
Helical: 88-108
Cytoplasmic: 109-135
Helical: 136-156
Extracellular: 157-174
Helical: 175-195
Cytoplasmic: 196-244

Rahman, A., Kobayashi, M., Sugimoto, K., Endo, Y., Kojima, M., Furukawa, S., ... & Chiba, H. (2021). Reduced Claudin-12 Expression Predicts Poor Prognosis in Cervical Cancer. International Journal of Molecular Sciences, 22(7), 3774.

Kolchakova, D., Moten, D., Batsalova, T., & Dzhambazov, B. (2021). Tight Junction Protein Claudin-12 Is Involved in Cell Migration during Metastasis. Biomolecules, 11(5), 636.

Beggs, M. R., Young, K., Pan, W., O’Neill, D. D., Saurette, M., Plain, A., ... & Alexander, R. T. (2021). Claudin-2 and claudin-12 form independent, complementary pores required to maintain calcium homeostasis. Proceedings of the National Academy of Sciences, 118(48).

Plain, A., Pan, W., O’Neill, D., Ure, M., Beggs, M. R., Farhan, M., ... & Alexander, R. T. (2020). Claudin-12 knockout mice demonstrate reduced proximal tubule calcium permeability. International journal of molecular sciences, 21(6), 2074.

Sun, L., Feng, L., & Cui, J. (2019). Increased expression of claudin‑12 promotes the metastatic phenotype of human bronchial epithelial cells and is associated with poor prognosis in lung squamous cell carcinoma. Experimental and therapeutic medicine, 17(1), 165-174.

Huang, J., Yin, P., & Zhang, L. (2019). COPII cargo claudin‐12 promotes hepatitis C virus entry. Journal of viral hepatitis, 26(2), 308-312.

Dias, M. C., Coisne, C., Baden, P., Enzmann, G., Garrett, L., Becker, L., ... & Engelhardt, B. (2019). Claudin-12 is not required for blood–brain barrier tight junction function. Fluids and Barriers of the CNS, 16(1), 1-17.

Tian, X., He, Y., Han, Z., Su, H., & Chu, C. (2019). The Cytoplasmic Expression Of CLDN12 Predicts An Unfavorable Prognosis And Promotes Proliferation And Migration Of Osteosarcoma. Cancer management and research, 11, 9339.

Du, Y., Zhou, L., Lin, Y., Yin, K., Yin, W., & Lu, J. (2019). Polymorphisms in microRNA let-7 binding sites of the HIF1AN and CLDN12 genes can predict pathologic complete response to taxane-and platinum-based neoadjuvant chemotherapy in breast cancer. Annals of translational medicine, 7(7).

Ask a question We look forward to hearing from you.
0 reviews or Q&As
Loading...
Have you used Human CLDN12 ELISA Kit?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

online inquiry
Online Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.