Human CTNNA2 ELISA Kit (V2LY-0626-LY2930)

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Tested Data
Datasheet
SDS
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
0.019 ng/mL
Detection Range
0.05-20 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
105.3 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
Catenin Alpha 2
Function
May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system (By similarity).

Required for proper regulation of cortical neuronal migration and neurite growth (PubMed:30013181).

It acts as negative regulator of Arp2/3 complex activity and Arp2/3-mediated actin polymerization (PubMed:30013181).

It thereby suppresses excessive actin branching which would impair neurite growth and stability (PubMed:30013181).

Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation (By similarity).
Biological Process
Axonogenesis Source: UniProtKB
Brain morphogenesis Source: UniProtKB
Cell-cell adhesion Source: UniProtKB
Cell migration Source: GO_Central
Dendrite morphogenesis Source: UniProtKB
Negative regulation of Arp2/3 complex-mediated actin nucleation Source: UniProtKB
Positive regulation of muscle cell differentiation Source: Reactome
Prepulse inhibition Source: UniProtKB
Radial glia guided migration of Purkinje cell Source: UniProtKB
Regulation of neuron migration Source: UniProtKB
Regulation of neuron projection development Source: UniProtKB
Regulation of synapse structural plasticity Source: UniProtKB
Cellular Location
Nucleus; Cell membrane; Cytoskeleton; Cytoplasm; Adherens junction; Axon
Involvement in disease
Cortical dysplasia, complex, with other brain malformations 9 (CDCBM9):
An autosomal recessive disorder characterized by neurodevelopmental delay apparent from early infancy, acquired microcephaly, hypotonic cerebral palsy, inability to ambulate or speak, and intractable seizures. Brain imaging shows pachygyria with severe cortical gray matter thickening, paucity of gyri without an obvious posterior-anterior gradient or focal dysplasias, hypogenesis of the corpus callosum, and cerebellar hypoplasia.

Wen, Y., Lin, A., Zhu, W., Wei, T., Luo, P., Guo, L., & Zhang, J. (2021). Catenin Alpha-2 Mutation Changes the Immune Microenvironment in Lung Adenocarcinoma Patients Receiving Immune Checkpoint Inhibitors. Frontiers in Pharmacology, 12.

Eszlari, N., Bagyura, Z., Millinghoffer, A., Nagy, T., Juhasz, G., Antal, P., ... & Bagdy, G. (2021). Catenin Alpha 2 May Be a Biomarker or Potential Drug Target in Psychiatric Disorders with Perseverative Negative Thinking. Pharmaceuticals, 14(9), 850.

Song, J., Zhang, P., Liu, M., Xie, M., Gao, Z., Wang, X., ... & Liu, R. (2019). Novel-miR-4885 promotes migration and invasion of esophageal Cancer cells through targeting CTNNA2. DNA and cell biology, 38(2), 151-161.

Schaffer, A. E., Breuss, M. W., Caglayan, A. O., Al-Sanaa, N., Al-Abdulwahed, H. Y., Kaymakcalan, H., ... & Gleeson, J. G. (2018). Biallelic loss of human CTNNA2, encoding αN-catenin, leads to ARP2/3 complex overactivity and disordered cortical neuronal migration. Nature genetics, 50(8), 1093-1101.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

CTNNA2 Matched Antibody Pair (315) (CAT#: APMAB-315LY)

Antibody Pairs

CTNNA2 Matched Antibody Pair (315) (CAT#: APMAB-315LY)

Related Products

CTNNA2 Matched Antibody Pair (315) (CAT#: APMAB-315LY)

Rabbit Anti-CTNNA2 Recombinant Antibody (CBLC285-LY) (CAT#: V2LY-0125-LY294)

Isotype control

For research use only. Not intended for any clinical use.

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