Human AFF2 ELISA Kit (V2LY-0626-LY4207)

Name: Human AFF2 ELISA Kit
SKU: V2LY-0626-LY4207
Rating: 5 (1 reviews)

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Tested Data

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity

0.0062 ng/mL

Detection Range

0.01-2 ng/mL

Sample Type

Serum, Plasma, cell culture supernates

Specificity

Human

Assay Type

Sandwich

Reactivity

Human

Assay Time

1.5 h

Molecule Mass

144.8 kDa

Components

Pre-coated ELISA Plate: 12 wells * 8 detachable strips
Standard solution: 0.5ml x1
Standard diluent: 3ml x1
Streptavidin-HRP: 6ml x1
Stop solution: 6ml x1
Substrate solution A: 6ml x1
Substrate solution B: 6ml x1
Wash buffer concentrate (25x): 20ml x1
Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 2-8°C

More Infomation

Target

Full Name

AF4/FMR2 family, member 2

Function

RNA-binding protein. Might be involved in alternative splicing regulation through an interaction with G-quartet RNA structure.

Biological Process

Brain development
Learning or memory
mRNA processing
Negative regulation of gene expression
Nuclear speck organization
Regulation of gene expression
Regulation of RNA splicing
RNA splicing

Cellular Location

Nucleus speckle. When splicing is inhibited, accumulates in enlarged speckles.

Involvement in disease

Mental retardation, X-linked, associated with fragile site FRAXE (MRFRAXE): A form of mild to moderate mental retardation associated with learning difficulties, communication deficits, attention problems, hyperactivity, and autistic behavior. It is associated with a fragile site on chromosome Xq28. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.

Silva, C., Maia, N., Santos, F., Rodrigues, B., Marques, I., Santos, R., & Jorge, P. (2021). Development and validation in 500 female samples of a TP-PCR assay to identify AFF2 GCC expansions. Scientific reports, 11(1), 1-6.

Kuo, Y. J., Lewis, J. S., Zhai, C., Chen, Y. A., Chernock, R. D., Hsieh, M. S., ... & Hang, J. F. (2021). DEK-AFF2 fusion-associated papillary squamous cell carcinoma of the sinonasal tract: clinicopathologic characterization of seven cases with deceptively bland morphology. Modern Pathology, 1-11.

Yuva-Aydemir, Y., Almeida, S., Krishnan, G., Gendron, T. F., & Gao, F. B. (2019). Transcription elongation factor AFF2/FMR2 regulates expression of expanded GGGGCC repeat-containing C9ORF72 allele in ALS/FTD. Nature communications, 10(1), 1-14.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Mouse Anti-AFF2 Recombinant Antibody (V2-611023) (CAT#: CBMAB-A0176-LY)

Isotype control

For research use only. Not intended for any clinical use.

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