Human FDPS ELISA Kit (V2LY-0626-LY4128)

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Tested Data
Datasheet
SDS
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Basic Information

Sensitivity
0.024 ng/mL
Detection Range
0.05-20 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
48.3 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase)
Research Area
Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
Biological Process
Cholesterol biosynthetic process Source: ProtInc
Farnesyl diphosphate biosynthetic process Source: GO_Central
Geranyl diphosphate biosynthetic process Source: UniProtKB-UniPathway
Cellular Location
Cytoplasm
Involvement in disease
Porokeratosis 9, multiple types (POROK9):
A form of porokeratosis, a disorder of faulty keratinization characterized by one or more atrophic patches surrounded by a distinctive hyperkeratotic ridgelike border called the cornoid lamella. The keratotic lesions can progress to overt cutaneous neoplasms, typically squamous cell carcinomas. Multiple clinical variants of porokeratosis are recognized, including porokeratosis of Mibelli, linear porokeratosis, disseminated superficial actinic porokeratosis, palmoplantar porokeratosis, and punctate porokeratosis. Different clinical presentations can be observed among members of the same family. Individuals expressing more than one variant have also been reported.

Oike, A., Iwata, S., Hirayama, A., Ono, Y., Nagasato, Y., Kawabata, Y., ... & Shigemura, N. (2022). Bisphosphonate affects the behavioral responses to HCl by disrupting farnesyl diphosphate synthase in mouse taste bud and tongue epithelial cells. Scientific Reports, 12(1), 1-15.

Jin, T., Lu, J., Lv, Q., Gong, Y., Feng, Z., Ying, H., ... & Jiang, D. (2022). Farnesyl diphosphate synthase regulated endothelial proliferation and autophagy during rat pulmonary arterial hypertension induced by monocrotaline. Molecular Medicine, 28(1), 1-16.

Tang, H. V., Berryman, D. L., Mendoza, J., Yactayo‐Chang, J. P., Li, Q. B., Christensen, S. A., ... & Block, A. K. (2022). Dedicated farnesyl diphosphate synthases circumvent isoprenoid‐derived growth‐defense tradeoffs in Zea mays. The Plant Journal, 112(1), 207-220.

Lin, P., Yan, Z. F., & Li, C. T. (2020). Effects of Exogenous Elicitors on Triterpenoids Accumulation and Expression of Farnesyl Diphosphate Synthase Gene in Inonotus obliquus. Biotechnology and Bioprocess Engineering, 25(4), 580-588.

Wang, X., Sun, T., Sun, J., Wang, S., Ma, Y., Liu, Z., ... & Zou, L. (2020). Molecular cloning, characterisation, and heterologous expression of farnesyl diphosphate synthase from Sanghuangporus baumii. Molecular Biotechnology, 62(2), 132-141.

Fei, Y., Li, N., Zhang, D. H., & Xu, J. W. (2019). Increased production of ganoderic acids by overexpression of homologous farnesyl diphosphate synthase and kinetic modeling of ganoderic acid production in Ganoderma lucidum. Microbial cell factories, 18(1), 1-9.

Wang, Z., Guo, H., Zhang, Y., Lin, L., Cui, M., Long, Y., & Xing, Z. (2019). DNA methylation of farnesyl pyrophosphate synthase, squalene synthase, and squalene epoxidase gene promoters and effect on the saponin content of Eleutherococcus Senticosus. Forests, 10(12), 1053.

Kim, H. Y., Kim, D. K., Bae, S. H., Gwak, H., Jeon, J. H., Kim, J. K., ... & Jang, H. (2018). Farnesyl diphosphate synthase is important for the maintenance of glioblastoma stemness. Experimental & molecular medicine, 50(10), 1-12.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant FDPS protein, His Tag (CAT#: V2LY-0526-LY4044)

Mouse Recombinant FDPS protein, His Tag (CAT#: V2LY-0526-LY8309)

Rat Fdps ELISA Kit (CAT#: V2LY-0626-LY2204)

Related Products

Human Recombinant FDPS protein, His Tag (CAT#: V2LY-0526-LY4044)

Rabbit Anti-FDPS Recombinant Antibody (CBXF-1864) (CAT#: CBMAB-F0627-CQ)

Mouse Recombinant FDPS protein, His Tag (CAT#: V2LY-0526-LY8309)

Rabbit Anti-FDPS Recombinant Antibody (CBXF-0485) (CAT#: CBMAB-F1209-CQ)

Mouse Anti-FDPS Recombinant Antibody (CBXF-0484) (CAT#: CBMAB-F3161-CQ)

Rabbit Anti-FDPS Recombinant Antibody (CBXF-1863) (CAT#: CBMAB-F3398-CQ)

Rat Fdps ELISA Kit (CAT#: V2LY-0626-LY2204)

Mouse Anti-FDPS Recombinant Antibody (CBXF-2942) (CAT#: CBMAB-F3649-CQ)

Rabbit Anti-FDPS Recombinant Antibody (
12H4) (CAT#: V2LY-0725-LY916)

Rabbit Anti-FDPS Recombinant Antibody (CBXF-1200) (CAT#: CBMAB-F2927-CQ)

Isotype control

For research use only. Not intended for any clinical use.

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