Human FGF12 ELISA Kit (V2LY-0626-LY4580)

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Tested Data
Request for COA
Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
0.01 ng/mL
Detection Range
0.02-4.5 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
27.4 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
Fibroblast Growth Factor 12
Research Area
Involved in nervous system development and function. Involved in the positive regulation of voltage-gated sodium channel activity. Promotes neuronal excitability by elevating the voltage dependence of neuronal sodium channel SCN8A fast inactivation.
Biological Process
Adult locomotory behavior Source: Ensembl
Cardiac muscle cell action potential involved in contraction Source: BHF-UCL
Cell-cell signaling Source: ProtInc
Chemical synaptic transmission Source: Ensembl
Fibroblast growth factor receptor signaling pathway Source: InterPro
Heart development Source: ProtInc
JNK cascade Source: MGI
Negative regulation of cation channel activity Source: Ensembl
Nervous system development Source: ProtInc
Neuromuscular process Source: Ensembl
Positive regulation of sodium ion transport Source: Ensembl
Regulation of membrane depolarization Source: Ensembl
Regulation of neuronal action potential Source: UniProtKB
Regulation of sodium ion transmembrane transport Source: BHF-UCL
Regulation of sodium ion transmembrane transporter activity Source: BHF-UCL
Regulation of voltage-gated sodium channel activity Source: UniProtKB
Signal transduction Source: ProtInc
Cellular Location
Nucleus
Involvement in disease
Developmental and epileptic encephalopathy 47 (DEE47):
A form of epileptic encephalopathy, a heterogeneous group of severe early-onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent.

Woo, J., Suh, W., & Sung, J. H. (2022). Hair Growth Regulation by Fibroblast Growth Factor 12 (FGF12). International Journal of Molecular Sciences, 23(16), 9467.

Liu, A., Zhang, Y., Xun, S., Zhou, G., Lin, L., & Mei, Y. (2022). Fibroblast growth factor 12 attenuated cardiac remodeling via suppressing oxidative stress. Peptides, 153, 170786.

Gao, X., Liao, Z., Su, R., Zheng, D., Huang, G., Huang, Z., & Cheng, X. (2022). Depletion of Fibroblast Growth Factor 12 Restrains the Viability, Stemness, and Motility of Colorectal Cancer. BioMed Research International, 2022.

Zhou, M., Chen, J., Meng, K., Zhang, Y., Zhang, M., Lu, P., ... & Tian, H. (2021). Production of bioactive recombinant human fibroblast growth factor 12 using a new transient expression vector in E. coli and its neuroprotective effects. Applied Microbiology and Biotechnology, 105(13), 5419-5431.

Yeo, Y., Yi, E. S., Kim, J. M., Jo, E. K., Seo, S., Kim, R. I., ... & Suh, W. (2020). FGF12 (fibroblast growth factor 12) inhibits vascular smooth muscle cell remodeling in pulmonary arterial hypertension. Hypertension, 76(6), 1778-1786.

Wu, J., Huang, H., Huang, Q., Qiu, R., Huang, M., & Meng, D. (2020). A functional variant rs1464938 in the promoter of fibroblast growth factor 12 is associated with an increased risk of bladder transitional cell carcinoma. Cytokine, 136, 155294.

Hanada, Y., Nakamura, Y., Ozono, Y., Ishida, Y., Takimoto, Y., Taniguchi, M., ... & Shimada, S. (2018). Fibroblast growth factor 12 is expressed in spiral and vestibular ganglia and necessary for auditory and equilibrium function. Scientific reports, 8(1), 1-10.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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