Human HJV ELISA Kit (V2LY-0626-LY3595)

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Datasheet
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Basic Information

Sensitivity
0.23 ng/mL
Detection Range
0.5-150 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
45.1 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
hemojuvelin BMP co-receptor
Function
Acts as a bone morphogenetic protein (BMP) coreceptor (PubMed:18976966).

Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis (PubMed:18976966).
Biological Process
Activin receptor signaling pathway Source: BHF-UCL
BMP signaling pathway Source: BHF-UCL
Cellular iron ion homeostasis Source: BHF-UCL
Cellular response to BMP stimulus Source: BHF-UCL
Iron ion homeostasis Source: MGI
Negative regulation of BMP signaling pathway Source: Ensembl
Negative regulation of transcription by RNA polymerase II Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Protein autoprocessing Source: BHF-UCL
Cellular Location
Cell membrane. Also released in the extracellular space.
Involvement in disease
Hemochromatosis 2A (HFE2A):
A juvenile form of hemochromatosis, a disorder of iron metabolism with excess deposition of iron in a variety of organs leading to their failure, bronze skin pigmentation, hepatic cirrhosis, arthropathy and diabetes. The most common symptoms of juvenile hemochromatosis at presentation are hypogonadism and cardiomyopathy.
PTM
Autocatalytically cleaved at low pH; the two chains remain linked via two disulfide bonds (PubMed:25156943). Also proteolytically processed by TMPRSS6, several fragments being released in the extracellular space; regulates HJV activity in BMP signaling and thefore iron homeostasis (PubMed:18976966, PubMed:25156943).

Novikov, N., Buch, A., Yang, H., Tuller, S., Andruk, M., Chan, K., ... & Savage, W. (2022). DISC-0974, an anti-hemojuvelin antibody, reduces hepcidin and mobilizes iron in healthy volunteers. Blood, 140(Supplement 1), 5339-5340.

Tippairote, T., Bjørklund, G., Peana, M., & Roytrakul, S. (2021). The proteomics study of compounded HFE/TF/TfR2/HJV genetic variations in a Thai family with iron overload, chronic anemia, and motor neuron disorder. Journal of Molecular Neuroscience, 71(3), 545-555.

Pettinato, M., Aghajan, M., Olivari, V., Dulja, A., Nai, A., Bordini, J., ... & Silvestri, L. (2019). Targeting the BMP Receptor Inhibitor FKBP12 to Upregulate Hepcidin in Wild-Type and Hemojuvelin-Hemochromatosis Models. Blood, 134, 955.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Cynomolgus Recombinant HJV protein, His Tag (CAT#: V2LY-0526-LY1530)

Human Recombinant HJV protein, His Tag (CAT#: V2LY-0526-LY4481)

Rat Hjv ELISA Kit (CAT#: V2LY-0626-LY1573)

Related Products

Human Recombinant HJV protein, His Tag (CAT#: V2LY-0526-LY4481)

Cynomolgus Recombinant HJV protein, His Tag (CAT#: V2LY-0526-LY1530)

Mouse Anti-HJV Recombinant Antibody (1D7) (CAT#: CBMAB-R0542-CN)

Mouse Anti-HJV Recombinant Antibody (A181) (CAT#: CBMAB-AP2955LY)

Mouse Anti-HJV Recombinant Antibody (A182) (CAT#: CBMAB-AP2957LY)

Mouse Anti-HJV Recombinant Antibody (A183) (CAT#: CBMAB-AP2954LY)

Rat Hjv ELISA Kit (CAT#: V2LY-0626-LY1573)

Mouse Anti-HJV Recombinant Antibody (CBFYH-3575) (CAT#: CBMAB-H4128-FY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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