Human KCNK9 ELISA Kit (V2LY-0626-LY1931)

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Tested Data
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Basic Information

Sensitivity
0.0099 ng/mL
Detection Range
0.02-7 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
42.3 kDa
Components
  • Pre-coated ELISA plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
Potassium Two Pore Domain Channel Subfamily K Member 9
Function
pH-dependent, voltage-insensitive, background potassium channel protein.
Biological Process
Potassium ion import across plasma membraneManual Assertion Based On ExperimentIDA:MGI
Potassium ion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Potassium ion transport1 PublicationNAS:UniProtKB
Stabilization of membrane potentialManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cell membrane
Involvement in disease
Birk-Barel syndrome (BIBARS):
A syndrome characterized by mental retardation, hypotonia, hyperactivity, and facial dysmorphism. BIBARS transmission pattern is consistent with autosomal dominant inheritance with paternal imprinting.
Topology
Cytoplasmic: 1-8
Helical: 9-29
Extracellular: 30-88
Pore-forming: 89-101
Extracellular: 102-107
Helical: 108-128
Cytoplasmic: 129-158
Helical: 159-179
Extracellular: 180-194
Pore-forming: 195-207
Extracellular: 208-218
Helical: 219-239
Cytoplasmic: 240-374

Cheng, Y., Tang, Y., Tan, Y., Li, J., & Zhang, X. (2023). KCNK9 mediates the inhibitory effects of genistein on hepatic metastasis from colon cancer. Clinics, 78, 100141.

Loftus, D., Bae, B., Whilden, C. M., & Whipple, A. J. (2023). Allelic chromatin structure primes imprinted expression of Kcnk9 during neurogenesis. bioRxiv, 2023-06.

Villavisanis, D. F., Blum, J. D., & Taylor, J. A. (2023). Birk-Barel Intellectual Disability Dimorphism and KCNK9 Imprinting Syndrome: Craniofacial Surgery Considerations for an Exceedingly Rare Syndrome. Journal of Craniofacial Surgery, 34(1), e25-e28.

Rojas, C. R., Cercy, J., Perillous, S., Gonthier-Guéret, C., Montibus, B., Maupetit-Méhouas, S., ... & Court, F. (2023). Biallelic non-productive enhancer-promoter interaction precedes imprinted expression of Kcnk9 during mouse neural commitment. bioRxiv, 2023-09.

Chu, L. H., Liao, C. C., Liew, P. L., Chen, C. W., Su, P. H., Wen, K. C., ... & Chen, L. Y. (2022). Epigenomic analysis reveals the KCNK9 potassium channel as a potential therapeutic target for adenomyosis. International journal of molecular sciences, 23(11), 5973.

Cousin, M. A., Veale, E. L., Dsouza, N. R., Tripathi, S., Holden, R. G., Arelin, M., ... & Klee, E. W. (2022). Gain and loss of TASK3 channel function and its regulation by novel variation cause KCNK9 imprinting syndrome. Genome medicine, 14(1), 62.

Pfeuffer, S., Müntefering, T., Rolfes, L., Straeten, F. A., Eichler, S., Gruchot, J., ... & Meuth, S. G. (2022). Deficiency of the Two-Pore Potassium Channel KCNK9 Impairs Intestinal Epithelial Cell Survival and Aggravates Dextran Sodium Sulfate-Induced Colitis. Cellular and Molecular Gastroenterology and Hepatology, 14(6), 1199-1211.

Skaar, D. A., Dietze, E. C., Alva-Ornelas, J. A., Ann, D., Schones, D. E., Hyslop, T., ... & Seewaldt, V. L. (2021). Epigenetic Dysregulation of KCNK9 Imprinting and Triple-Negative Breast Cancer. Cancers, 13(23), 6031.

Šedivá, M., Laššuthová, P., Zámečník, J., Sedláčková, L., Seeman, P., & Haberlová, J. (2020). Novel variant in the KCNK9 gene in a girl with Birk Barel syndrome. European Journal of Medical Genetics, 63(1), 103619.

Cunningham, K. P., MacIntyre, D. E., Mathie, A., & Veale, E. L. (2020). Effects of the ventilatory stimulant, doxapram on human TASK‐3 (KCNK9, K2P9. 1) channels and TASK‐1 (KCNK3, K2P3. 1) channels. Acta physiologica, 228(2), e13361.

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For research use only. Not intended for any clinical use.

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