Mouse Anti-KCNK9 Recombinant Antibody (KCN-75) (CBMAB-K0589-LY)

Name: Mouse Anti-KCNK9 Recombinant Antibody (KCN-75)
SKU: CBMAB-K0589-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

KCN-75

Application

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

2.4 mg/ml

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Potassium Two Pore Domain Channel Subfamily K Member 9

Introduction

This gene encodes a protein that contains multiple transmembrane regions and two pore-forming P domains and functions as a pH-dependent potassium channel. Amplification and overexpression of this gene have been observed in several types of human carcinomas. This gene is imprinted in the brain, with preferential expression from the maternal allele. A mutation in this gene was associated with Birk-Barel dysmorphism syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017]

Entrez Gene ID

51305

UniProt ID

Q9NPC2

Alternative Names

Potassium Two Pore Domain Channel Subfamily K Member 9; Potassium Channel; Two Pore Domain Subfamily K; Member 9; Acid-Sensitive Potassium Channel Protein TASK-3; TWIK-Related Acid-Sensitive K(+) Channel 3; Two Pore Potassium Channel KT3.2; Two Pore K(+) Channel KT3.2; TASK3;

Function

pH-dependent, voltage-insensitive, background potassium channel protein.

Biological Process

Potassium ion import across plasma membraneManual Assertion Based On ExperimentIDA:MGI
Potassium ion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Potassium ion transport1 PublicationNAS:UniProtKB
Stabilization of membrane potentialManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cell membrane

Involvement in disease

Birk-Barel syndrome (BIBARS):
A syndrome characterized by mental retardation, hypotonia, hyperactivity, and facial dysmorphism. BIBARS transmission pattern is consistent with autosomal dominant inheritance with paternal imprinting.

Topology

Cytoplasmic: 1-8
Helical: 9-29
Extracellular: 30-88
Pore-forming: 89-101
Extracellular: 102-107
Helical: 108-128
Cytoplasmic: 129-158
Helical: 159-179
Extracellular: 180-194
Pore-forming: 195-207
Extracellular: 208-218
Helical: 219-239
Cytoplasmic: 240-374

Cheng, Y., Tang, Y., Tan, Y., Li, J., & Zhang, X. (2023). KCNK9 mediates the inhibitory effects of genistein on hepatic metastasis from colon cancer. Clinics, 78, 100141.

Loftus, D., Bae, B., Whilden, C. M., & Whipple, A. J. (2023). Allelic chromatin structure primes imprinted expression of Kcnk9 during neurogenesis. bioRxiv, 2023-06.

Villavisanis, D. F., Blum, J. D., & Taylor, J. A. (2023). Birk-Barel Intellectual Disability Dimorphism and KCNK9 Imprinting Syndrome: Craniofacial Surgery Considerations for an Exceedingly Rare Syndrome. Journal of Craniofacial Surgery, 34(1), e25-e28.

Rojas, C. R., Cercy, J., Perillous, S., Gonthier-Guéret, C., Montibus, B., Maupetit-Méhouas, S., ... & Court, F. (2023). Biallelic non-productive enhancer-promoter interaction precedes imprinted expression of Kcnk9 during mouse neural commitment. bioRxiv, 2023-09.

Chu, L. H., Liao, C. C., Liew, P. L., Chen, C. W., Su, P. H., Wen, K. C., ... & Chen, L. Y. (2022). Epigenomic analysis reveals the KCNK9 potassium channel as a potential therapeutic target for adenomyosis. International journal of molecular sciences, 23(11), 5973.

Cousin, M. A., Veale, E. L., Dsouza, N. R., Tripathi, S., Holden, R. G., Arelin, M., ... & Klee, E. W. (2022). Gain and loss of TASK3 channel function and its regulation by novel variation cause KCNK9 imprinting syndrome. Genome medicine, 14(1), 62.

Pfeuffer, S., Müntefering, T., Rolfes, L., Straeten, F. A., Eichler, S., Gruchot, J., ... & Meuth, S. G. (2022). Deficiency of the Two-Pore Potassium Channel KCNK9 Impairs Intestinal Epithelial Cell Survival and Aggravates Dextran Sodium Sulfate-Induced Colitis. Cellular and Molecular Gastroenterology and Hepatology, 14(6), 1199-1211.

Skaar, D. A., Dietze, E. C., Alva-Ornelas, J. A., Ann, D., Schones, D. E., Hyslop, T., ... & Seewaldt, V. L. (2021). Epigenetic Dysregulation of KCNK9 Imprinting and Triple-Negative Breast Cancer. Cancers, 13(23), 6031.

Šedivá, M., Laššuthová, P., Zámečník, J., Sedláčková, L., Seeman, P., & Haberlová, J. (2020). Novel variant in the KCNK9 gene in a girl with Birk Barel syndrome. European Journal of Medical Genetics, 63(1), 103619.

Cunningham, K. P., MacIntyre, D. E., Mathie, A., & Veale, E. L. (2020). Effects of the ventilatory stimulant, doxapram on human TASK‐3 (KCNK9, K2P9. 1) channels and TASK‐1 (KCNK3, K2P3. 1) channels. Acta physiologica, 228(2), e13361.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
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For research use only. Not intended for any clinical use.

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