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Mouse Anti-KCNK9 Recombinant Antibody (KCN-75) (CBMAB-K0589-LY)

This product is antibody recognizes KCNK9. The antibody KCN-75 immunoassay techniques such as: WB.
See all KCNK9 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
KCN-75
Antibody Isotype
IgG2b
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
2.4 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Potassium Two Pore Domain Channel Subfamily K Member 9
Introduction
This gene encodes a protein that contains multiple transmembrane regions and two pore-forming P domains and functions as a pH-dependent potassium channel. Amplification and overexpression of this gene have been observed in several types of human carcinomas. This gene is imprinted in the brain, with preferential expression from the maternal allele. A mutation in this gene was associated with Birk-Barel dysmorphism syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017]
Entrez Gene ID
51305
UniProt ID
Q9NPC2
Alternative Names
Potassium Two Pore Domain Channel Subfamily K Member 9; Potassium Channel; Two Pore Domain Subfamily K; Member 9; Acid-Sensitive Potassium Channel Protein TASK-3; TWIK-Related Acid-Sensitive K(+) Channel 3; Two Pore Potassium Channel KT3.2; Two Pore K(+) Channel KT3.2; TASK3;
Function
pH-dependent, voltage-insensitive, background potassium channel protein.
Biological Process
Potassium ion import across plasma membraneManual Assertion Based On ExperimentIDA:MGI
Potassium ion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Potassium ion transport1 PublicationNAS:UniProtKB
Stabilization of membrane potentialManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cell membrane
Involvement in disease
Birk-Barel syndrome (BIBARS):
A syndrome characterized by mental retardation, hypotonia, hyperactivity, and facial dysmorphism. BIBARS transmission pattern is consistent with autosomal dominant inheritance with paternal imprinting.
Topology
Cytoplasmic: 1-8
Helical: 9-29
Extracellular: 30-88
Pore-forming: 89-101
Extracellular: 102-107
Helical: 108-128
Cytoplasmic: 129-158
Helical: 159-179
Extracellular: 180-194
Pore-forming: 195-207
Extracellular: 208-218
Helical: 219-239
Cytoplasmic: 240-374

Cheng, Y., Tang, Y., Tan, Y., Li, J., & Zhang, X. (2023). KCNK9 mediates the inhibitory effects of genistein on hepatic metastasis from colon cancer. Clinics, 78, 100141.

Loftus, D., Bae, B., Whilden, C. M., & Whipple, A. J. (2023). Allelic chromatin structure primes imprinted expression of Kcnk9 during neurogenesis. bioRxiv, 2023-06.

Villavisanis, D. F., Blum, J. D., & Taylor, J. A. (2023). Birk-Barel Intellectual Disability Dimorphism and KCNK9 Imprinting Syndrome: Craniofacial Surgery Considerations for an Exceedingly Rare Syndrome. Journal of Craniofacial Surgery, 34(1), e25-e28.

Rojas, C. R., Cercy, J., Perillous, S., Gonthier-Guéret, C., Montibus, B., Maupetit-Méhouas, S., ... & Court, F. (2023). Biallelic non-productive enhancer-promoter interaction precedes imprinted expression of Kcnk9 during mouse neural commitment. bioRxiv, 2023-09.

Chu, L. H., Liao, C. C., Liew, P. L., Chen, C. W., Su, P. H., Wen, K. C., ... & Chen, L. Y. (2022). Epigenomic analysis reveals the KCNK9 potassium channel as a potential therapeutic target for adenomyosis. International journal of molecular sciences, 23(11), 5973.

Cousin, M. A., Veale, E. L., Dsouza, N. R., Tripathi, S., Holden, R. G., Arelin, M., ... & Klee, E. W. (2022). Gain and loss of TASK3 channel function and its regulation by novel variation cause KCNK9 imprinting syndrome. Genome medicine, 14(1), 62.

Pfeuffer, S., Müntefering, T., Rolfes, L., Straeten, F. A., Eichler, S., Gruchot, J., ... & Meuth, S. G. (2022). Deficiency of the Two-Pore Potassium Channel KCNK9 Impairs Intestinal Epithelial Cell Survival and Aggravates Dextran Sodium Sulfate-Induced Colitis. Cellular and Molecular Gastroenterology and Hepatology, 14(6), 1199-1211.

Skaar, D. A., Dietze, E. C., Alva-Ornelas, J. A., Ann, D., Schones, D. E., Hyslop, T., ... & Seewaldt, V. L. (2021). Epigenetic Dysregulation of KCNK9 Imprinting and Triple-Negative Breast Cancer. Cancers, 13(23), 6031.

Šedivá, M., Laššuthová, P., Zámečník, J., Sedláčková, L., Seeman, P., & Haberlová, J. (2020). Novel variant in the KCNK9 gene in a girl with Birk Barel syndrome. European Journal of Medical Genetics, 63(1), 103619.

Cunningham, K. P., MacIntyre, D. E., Mathie, A., & Veale, E. L. (2020). Effects of the ventilatory stimulant, doxapram on human TASK‐3 (KCNK9, K2P9. 1) channels and TASK‐1 (KCNK3, K2P3. 1) channels. Acta physiologica, 228(2), e13361.

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For research use only. Not intended for any clinical use.

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