Human LAMA3 ELISA Kit (V2LY-0626-LY4791)

Name: Human LAMA3 ELISA Kit
SKU: V2LY-0626-LY4791
Rating: 5 (1 reviews)

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Tested Data

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity

3.15 ng/mL

Detection Range

5-1000 ng/mL

Sample Type

Serum, Plasma, cell culture supernates

Specificity

Human

Assay Type

Sandwich

Reactivity

Human

Assay Time

1.5 h

Molecule Mass

366.6 kDa

Components

Pre-coated ELISA Plate: 12 wells * 8 detachable strips
Standard solution: 0.5ml x1
Standard diluent: 3ml x1
Streptavidin-HRP: 6ml x1
Stop solution: 6ml x1
Substrate solution A: 6ml x1
Substrate solution B: 6ml x1
Wash buffer concentrate (25x): 20ml x1
Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 2-8°C

More Infomation

Target

Full Name

laminin subunit alpha 3

Function

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
Laminin-5 is thought to be involved in (1) cell adhesion via integrin alpha-3/beta-1 in focal adhesion and integrin alpha-6/beta-4 in hemidesmosomes, (2) signal transduction via tyrosine phosphorylation of pp125-FAK and p80, (3) differentiation of keratinocytes.

Biological Process

Animal organ morphogenesisManual Assertion Based On ExperimentIBA:GO_Central
Axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Cell-cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Endodermal cell differentiationManual Assertion Based On ExperimentIEP:UniProtKB
Epidermis developmentManual Assertion Based On ExperimentTAS:ProtInc
Integrin-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Morphogenesis of a polarized epitheliumManual Assertion Based On ExperimentIBA:GO_Central
Regulation of cell adhesionIEA:InterPro
Regulation of cell migrationIEA:InterPro
Regulation of embryonic developmentIEA:InterPro
Tissue developmentManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Secreted, extracellular space, extracellular matrix, basement membrane
Major component.

Involvement in disease

Epidermolysis bullosa, junctional, Herlitz type (H-JEB):
An infantile and lethal form of junctional epidermolysis bullosa, a group of blistering skin diseases characterized by tissue separation which occurs within the dermo-epidermal basement In the Herlitz type, death occurs usually within the first six months of life. Occasionally, children survive to teens. It is marked by bullous lesions at birth and extensive denudation of skin and mucous membranes that may be hemorrhagic.
Laryngoonychocutaneous syndrome (LOCS):
Autosomal recessive epithelial disorder confined to the Punjabi Muslim population. The condition is characterized by cutaneous erosions, nail dystrophy and exuberant vascular granulation tissue in certain epithelia, especially conjunctiva and larynx.

Shu, C., Wang, W., Wu, L., Qi, C., Yan, W., Lu, W., ... & Shang, A. (2023). LINC00936/MicroRNA-221-3p Regulates Tumor Progression in Ovarian Cancer by Interacting with LAMA3. Recent Patents on Anti-Cancer Drug Discovery, 18(1), 66-79.

Wang, S. K., Zhang, H., Wang, Y. L., Seymen, F., Koruyucu, M., Simmer, J. P., & Hu, J. C. C. (2022). Phenotypic variability in LAMA3‐associated amelogenesis imperfecta. Oral Diseases.

Tian, C., Li, X., & Ge, C. (2021). High expression of LAMA3/AC245041. 2 gene pair associated with KRAS mutation and poor survival in pancreatic adenocarcinoma: a comprehensive TCGA analysis. Molecular Medicine, 27(1), 62.

Herrmann, I., Linder, K. E., Meurs, K. M., Friedenberg, S. G., Cullen, J., Olby, N., & Bizikova, P. (2021). Canine junctional epidermolysis bullosa due to a novel mutation in LAMA3 with severe upper respiratory involvement. Veterinary dermatology, 32(4), 379-e108.

Li, Y., Zhang, J., Cheng, Z., Wang, Y., Huang, T., Lai, K., ... & Yang, G. (2020). Adenovirus-mediated LAMA3 transduction enhances hemidesmosome formation and periodontal reattachment during wound healing. Molecular Therapy-Methods & Clinical Development, 18, 291-303.

Tang, L., Wang, P., Wang, Q., & Zhong, L. (2019). Correlation of LAMA3 with onset and prognosis of ovarian cancer. Oncology Letters, 18(3), 2813-2818.

Xu, S. F., Zheng, Y., Zhang, L., Wang, P., Niu, C. M., Wu, T., ... & Gao, L. M. (2019). Long non-coding RNA LINC00628 interacts epigenetically with the LAMA3 promoter and contributes to lung adenocarcinoma. Molecular Therapy-Nucleic Acids, 18, 166-182.

Zhang, J., Wang, H., Wang, Y., Dong, W., Jiang, Z., & Yang, G. (2018). Substrate-mediated gene transduction of LAMA3 for promoting biological sealing between titanium surface and gingival epithelium. Colloids and Surfaces B: Biointerfaces, 161, 314-323.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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