Human LAMA4 ELISA Kit (V2LY-0626-LY4792)

Name: Human LAMA4 ELISA Kit
SKU: V2LY-0626-LY4792
Rating: 5 (1 reviews)

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Tested Data

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity

0.008 ng/mL

Detection Range

0.015-3 ng/mL

Sample Type

Serum, Plasma, cell culture supernates

Specificity

Human

Assay Type

Sandwich

Reactivity

Human

Assay Time

1.5 h

Molecule Mass

202.5 kDa

Components

Pre-coated ELISA Plate: 12 wells * 8 detachable strips
Standard solution: 0.5ml x1
Standard diluent: 3ml x1
Streptavidin-HRP: 6ml x1
Stop solution: 6ml x1
Substrate solution A: 6ml x1
Substrate solution B: 6ml x1
Wash buffer concentrate (25x): 20ml x1
Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 2-8°C

More Infomation

Target

Full Name

laminin subunit alpha 4

Function

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

Biological Process

Cell adhesionIEA:UniProtKB-KW
Negative regulation of cold-induced thermogenesisBy SimilarityISS:YuBioLab
Regulation of cell adhesionIEA:InterPro
Regulation of cell migrationIEA:InterPro
Regulation of embryonic developmentIEA:InterPro

Cellular Location

Secreted, extracellular space, extracellular matrix, basement membrane
Major component.

Involvement in disease

Cardiomyopathy, dilated 1JJ (CMD1JJ):
A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.

Cai, H., Kondo, M., Sandhow, L., Xiao, P., Johansson, A. S., Sasaki, T., ... & Qian, H. (2022). Critical role of Lama4 for hematopoiesis regeneration and acute myeloid leukemia progression. Blood, The Journal of the American Society of Hematology, 139(20), 3040-3057.

Ren, Y., Yang, X., Luo, Z., Wu, J., & Lin, H. (2022). HIF-1α aggravates pathologic myopia through the miR-150-5p/LAMA4/p38 MAPK signaling axis. Molecular and Cellular Biochemistry, 1-10.

Wang, M., Li, C., Liu, Y., & Wang, Z. (2021). Effect of LAMA4 on prognosis and its correlation with immune infiltration in gastric cancer. BioMed Research International, 2021.

Zheng, B., Qu, J., Ohuchida, K., Feng, H., Chong, S. J. F., Yan, Z., ... & Nakamura, M. (2020). LAMA4 upregulation is associated with high liver metastasis potential and poor survival outcome of Pancreatic Cancer. Theranostics, 10(22), 10274.

Liu, Y., Xu, Y., Ding, L., Yu, L., Zhang, B., & Wei, D. (2020). LncRNA MEG3 suppressed the progression of ovarian cancer via sponging miR-30e-3p and regulating LAMA4 expression. Cancer Cell International, 20(1), 1-15.

Peng, L., Li, Y., Wei, S., Li, X., Dang, Y., Zhang, W., & Zhang, G. (2020). LAMA4 activated by Androgen receptor induces the cisplatin resistance in gastric cancer. Biomedicine & Pharmacotherapy, 124, 109667.

Shkurnikov, M., Nikulin, S., Nersisyan, S., Poloznikov, A., Zaidi, S., Baranova, A., ... & Tonevitsky, A. (2019). LAMA4-regulating miR-4274 and its host gene SORCS2 play a role in IGFBP6-dependent effects on phenotype of basal-like breast cancer. Frontiers in molecular biosciences, 6, 122.

Li, Y., Guan, B., Liu, J., Zhang, Z., He, S., Zhan, Y., ... & Zhao, W. (2019). MicroRNA-200b is downregulated and suppresses metastasis by targeting LAMA4 in renal cell carcinoma. EBioMedicine, 44, 439-451.

Yang, Z. X., Zhang, B., Wei, J., Jiang, G. Q., Wu, Y. L., Leng, B. J., & Xing, C. G. (2018). MiR-539 inhibits proliferation and migration of triple-negative breast cancer cells by down-regulating LAMA4 expression. Cancer cell international, 18(1), 1-10.

Wang, X., Hou, Q., & Zhou, X. (2018). LAMA4 expression is activated by zinc finger E‑box‑binding homeobox 1 and independently predicts poor overall survival in gastric cancer. Oncology Reports, 40(3), 1725-1733.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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