Human LGI4 ELISA Kit (V2LY-0626-LY4802)

Name: Human LGI4 ELISA Kit
SKU: V2LY-0626-LY4802
Rating: 5 (1 reviews)

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Tested Data

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity

0.051 ng/mL

Detection Range

0.1-40 ng/mL

Sample Type

Serum, Plasma, cell culture supernates

Specificity

Human

Assay Type

Sandwich

Reactivity

Human

Assay Time

1.5 h

Molecule Mass

59.1 kDa

Components

Pre-coated ELISA Plate: 12 wells * 8 detachable strips
Standard solution: 0.5ml x1
Standard diluent: 3ml x1
Streptavidin-HRP: 6ml x1
Stop solution: 6ml x1
Substrate solution A: 6ml x1
Substrate solution B: 6ml x1
Wash buffer concentrate (25x): 20ml x1
Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 2-8°C

More Infomation

Target

Full Name

LGI4

Function

Component of Schwann cell signaling pathway(s) that controls axon segregation and myelin formation (By similarity).

Biological Process

Adult locomotory behaviorIEA:Ensembl
Glial cell proliferationIEA:Ensembl
Myelination in peripheral nervous systemManual Assertion Based On ExperimentIBA:GO_Central
Neuron maturationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of myelinationManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Secreted

Involvement in disease

Arthrogryposis multiplex congenita 1, neurogenic, with myelin defect (AMC1):
A form of arthrogryposis multiplex congenita, a developmental condition characterized by multiple joint contractures resulting from reduced or absent fetal movements. AMC1 is an autosomal recessive severe form with onset in utero. Most affected individuals die in utero. Those who survive have generalized contractures and hypotonia. The disorder is caused by a neurogenic defect and poor or absent myelin formation around peripheral nerves rather than by a muscular defect.

Zhang, X., Kira, J. I., Ogata, H., Imamura, T., Mitsuishi, M., Fujii, T., ... & Nakamura, Y. (2023). Anti-LGI4 Antibody Is a Novel Juxtaparanodal Autoantibody for Chronic Inflammatory Demyelinating Polyneuropathy. Neurology-Neuroimmunology Neuroinflammation, 10(2).

Mishra, S., Rai, A., Srivastava, P., & Phadke, S. R. (2020). A mild phenotype of LGI4-related arthrogryposis multiplex congenita with intrafamilial variability. European Journal of Medical Genetics, 63(3), 103756.

Gupta, G., Kumar, N., & Chandra, R. (2018). ASSOCIATION ANALYSIS OF [gamma] 2 SUBUNIT OF [gamma]-AMINOBUTYRIC ACID TYPE-A RECEPTOR (GABRG2) AND LEUCINE-RICH GLIOMA-INACTIVATED 4 GENE (LGI-4) POLYMORPHISMS WITH IDIOPATHIC EPILEPSIES AND FEBRILE SEIZURES. Journal of Evolution of Medical and Dental Sciences, 7(39), 5082-5086.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Rat Anti-LGI4 Recombinant Antibody (KT18) (CAT#: CBMAB-AO701LY)

Rat Anti-LGI4 Recombinant Antibody (CBYCL-278) (CAT#: CBMAB-L0179-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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