Human, Mouse, Rat, Cynomolgus, Rhesus, Rabbit Recombinant INHBAA protein (V2LY-0526-LY7716)

Name: Human, Mouse, Rat, Cynomolgus, Rhesus, Rabbit Recombinant INHBAA protein
SKU: V2LY-0526-LY7716
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human, Mouse, Rat, Cynomolgus, Rhesus, Rabbit

Protein Construction

This product is Human, Mouse, Rat, Cynomolgus, Rhesus, Rabbit Recombinant INHBAA protein consist of Amino Acid: 311-426 and predicts a molecular mass of 13 kDa.

Molecule Mass

13 kDa

Verified

HPLC

Sequence

Amino Acid: 311-426

Species

Human, Mouse, Rat, Cynomolgus, Rhesus, Rabbit

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥95% as determined by SDS-PAGE. ≥95% as determined by SEC-HPLC

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile Tirs, NaCl, Glycerol, DTT

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Inhibin Beta A Subunit

Function

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

Biological Process

Activin receptor signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Cell differentiationManual Assertion Based On ExperimentTAS:UniProtKB
Cell surface receptor signaling pathwayManual Assertion Based On ExperimentTAS:UniProtKB
Cell-cell signalingManual Assertion Based On ExperimentTAS:UniProtKB
Cellular response to cholesterolIEA:Ensembl
Cellular response to follicle-stimulating hormone stimulusIEA:Ensembl
Defense responseManual Assertion Based On ExperimentTAS:UniProtKB
Endodermal cell differentiationManual Assertion Based On ExperimentIDA:BHF-UCL
Erythrocyte differentiation1 PublicationNAS:UniProtKB
Extrinsic apoptotic signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Eyelid development in camera-type eyeISS:UniProtKB
GABAergic neuron differentiationManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Hair follicle developmentManual Assertion Based On ExperimentIGI:UniProtKB
Hematopoietic progenitor cell differentiationManual Assertion Based On ExperimentIDA:UniProtKB
Hemoglobin biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Male gonad developmentManual Assertion Based On ExperimentIGI:UniProtKB
Mesodermal cell differentiationIEA:Ensembl
Negative regulation of B cell differentiationManual Assertion Based On ExperimentTAS:UniProtKB
Negative regulation of cell growthManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of follicle-stimulating hormone secretion1 PublicationNAS:UniProtKB
Negative regulation of G1/S transition of mitotic cell cycleManual Assertion Based On ExperimentIDA:HGNC-UCL
Negative regulation of interferon-gamma productionManual Assertion Based On ExperimentTAS:UniProtKB
Negative regulation of macrophage differentiationManual Assertion Based On ExperimentTAS:UniProtKB
Negative regulation of phosphorylationManual Assertion Based On ExperimentTAS:UniProtKB
Nervous system development1 PublicationNAS:UniProtKB
OdontogenesisManual Assertion Based On ExperimentIGI:UniProtKB
Ovarian follicle developmentManual Assertion Based On ExperimentIGI:UniProtKB
Positive regulation of cellular protein metabolic processManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of erythrocyte differentiationManual Assertion Based On ExperimentIDA:HGNC-UCL
Positive regulation of extrinsic apoptotic signaling pathway in absence of ligandManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of follicle-stimulating hormone secretionManual Assertion Based On ExperimentTAS:UniProtKB
Positive regulation of gene expressionManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of ovulationISS:UniProtKB
Positive regulation of pathway-restricted SMAD protein phosphorylationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Progesterone secretionManual Assertion Based On ExperimentIGI:UniProtKB
Regulation of follicle-stimulating hormone secretionManual Assertion Based On ExperimentIGI:UniProtKB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Response to xenobiotic stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Roof of mouth developmentManual Assertion Based On ExperimentIGI:UniProtKB
SMAD protein signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Striatal medium spiny neuron differentiationManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL

Cellular Location

Secreted

Liu, F., Liu, J., Shi, X., Hu, X., Wei, L., Huo, B., ... & Yang, L. (2023). Identification of INHBA as a potential biomarker for gastric cancer through a comprehensive analysis. Scientific Reports, 13(1), 12494.

Xiao, Q., Xiao, J., Liu, J., Liu, J., Shu, G., & Yin, G. (2022). Metformin suppresses the growth of colorectal cancer by targeting INHBA to inhibit TGF-β/PI3K/AKT signaling transduction. Cell Death & Disease, 13(3), 202.

Qiu, S., Li, B., Xia, Y., Xuan, Z., Li, Z., Xie, L., ... & Xu, Z. (2022). CircTHBS1 drives gastric cancer progression by increasing INHBA mRNA expression and stability in a ceRNA-and RBP-dependent manner. Cell death & disease, 13(3), 266.

Mouti, M. A., & Pauklin, S. (2021). TGFB1/INHBA homodimer/nodal-SMAD2/3 signaling network: a pivotal molecular target in PDAC treatment. Molecular Therapy, 29(3), 920-936.

Bao, Y., Yao, X., Li, X., Ei-Samahy, M. A., Yang, H., Liang, Y., ... & Wang, F. (2021). INHBA transfection regulates proliferation, apoptosis and hormone synthesis in sheep granulosa cells. Theriogenology, 175, 111-122.

Li, X., Yu, W., Liang, C., Xu, Y., Zhang, M., Ding, X., & Cai, X. (2020). INHBA is a prognostic predictor for patients with colon adenocarcinoma. BMC cancer, 20, 1-10.

Zhang, C., Liang, Y., Ma, M. H., Wu, K. Z., & Dai, D. Q. (2019). KRT15, INHBA, MATN3, and AGT are aberrantly methylated and differentially expressed in gastric cancer and associated with prognosis. Pathology-Research and Practice, 215(5), 893-899.

Chen, Z. L., Qin, L., Peng, X. B., Hu, Y., & Liu, B. (2019). INHBA gene silencing inhibits gastric cancer cell migration and invasion by impeding activation of the TGF‐β signaling pathway. Journal of cellular physiology, 234(10), 18065-18074.

Lyu, S., Jiang, C., Xu, R., Huang, Y., & Yan, S. (2018). INHBA upregulation correlates with poorer prognosis in patients with esophageal squamous cell carcinoma. Cancer management and research, 1585-1596.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human, Mouse, Rat, Cynomolgus, Rhesus Recombinant INHBAA protein (CAT#: V2LY-0526-LY7715)

Human, Mouse, Rat, Cynomolgus, Rhesus Recombinant INHBA, GMP grade protein (CAT#: V2LY-0526-LY7714)

Mouse Recombinant INHBA protein, His Tag (CAT#: V2LY-0526-LY7771)

Related Products

Human, Mouse, Rat, Cynomolgus, Rhesus Recombinant INHBAA protein (CAT#: V2LY-0526-LY7715)

Human, Mouse, Rat, Cynomolgus, Rhesus Recombinant INHBA, GMP grade protein (CAT#: V2LY-0526-LY7714)

Mouse Anti-INHBA Recombinant Antibody (CF244) (CAT#: CBMAB-FT243LY)

Mouse Anti-INHBA Recombinant Antibody (9H16) (CAT#: CBMAB-A4492-YC)

Mouse Anti-INHBA Recombinant Antibody (A624) (CAT#: CBMAB-AP10877LY)

Rabbit Anti-INHBA Recombinant Antibody (105) (CAT#: CBMAB-A4493-YC)

Mouse Recombinant INHBA protein, His Tag (CAT#: V2LY-0526-LY7771)

Mouse Anti-INHBA Recombinant Antibody (A623) (CAT#: CBMAB-AP10878LY)

Mouse Anti-INHBA Recombinant Antibody (7L18) (CAT#: CBMAB-A4491-YC)

Mouse Anti-INHBA Recombinant Antibody (A626) (CAT#: CBMAB-AP3798LY)

Isotype control

For research use only. Not intended for any clinical use.

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