Human PYGL ELISA Kit (V2LY-0626-LY4199)

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Tested Data
Datasheet
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Basic Information

Sensitivity
0.027 ng/mL
Detection Range
0.05-30 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
97.1 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
liver glycogen phosphorylase
Function
Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
Biological Process
Biological Process 5-phosphoribose 1-diphosphate biosynthetic processIEA:Ensembl
Biological Process glucose homeostasisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process glycogen catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process glycogen metabolic processManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process necroptotic processIEA:Ensembl
Biological Process response to bacteriumIEA:Ensembl
Cellular Location
Cytoplasm, cytosol
Involvement in disease
Glycogen storage disease 6 (GSD6):
A metabolic disorder characterized by mild to moderate hypoglycemia, mild ketosis, growth retardation, and prominent hepatomegaly. Heart and skeletal muscle are not affected.
PTM
Acetylation, which is up-regulated by glucose and insulin and down-regulated by glucagon, inhibits the glycogen phosphorylase activity by promoting PPP1R3B-mediated recruitment of phosphatase PP1 and Ser-15 dephosphorylation.
Phosphorylation at Ser-15 converts inactive phosphorylase b into active phosphorylase a (PubMed:10949035).
Dephosphorylation of Ser-15 by phosphatase PP1 inactivates the enzyme (PubMed:22225877).
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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-PYGL Recombinant Antibody (2) (CAT#: CBMAB-G6516-LY)

Mouse Anti-PYGL Recombinant Antibody (CBLG1-2428) (CAT#: CBMAB-G6517-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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