Human Recombinant Adrenomedullin protein, hFc Tag (V2LY-0526-LY1955)

Name: Human Recombinant Adrenomedullin protein, hFc Tag
SKU: V2LY-0526-LY1955
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

hFc Tag

Protein Construction

This product is Human Recombinant Adrenomedullin protein, hFc Tag consist of Amino Acid: 95-146 and predicts a molecular mass of 38 kDa.

Molecule Mass

38 kDa

Verified

HPLC

Sequence

Amino Acid: 95-146

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥93% as determined by SDS-PAGE. ≥95% as determined by SEC-HPLC.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile Tris, NaCl, Glutathione, EDTA, DTT, PMSF, Glycerol

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Adrenomedullin

Function

AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels.

Biological Process

Adenylate cyclase-activating G protein-coupled receptor signaling pathway
Adrenomedullin receptor signaling pathway
Aging
Amylin receptor signaling pathway
Androgen metabolic process
Animal organ regeneration
Antibacterial humoral response
Antimicrobial humoral immune response mediated by antimicrobial peptide
Branching involved in labyrinthine layer morphogenesis
Defense response to Gram-negative bacterium
Defense response to Gram-positive bacterium
Developmental growth
Female pregnancy Source: Ensembl
G protein-coupled receptor internalization
G protein-coupled receptor signaling pathway
Heart development
Hormone secretion
Inflammatory response
Negative regulation of cell population proliferation
Negative regulation of inflammatory response to antigenic stimulus
Negative regulation of vascular permeability
Negative regulation of vasoconstriction
Neural tube closure
Neuron projection regeneration
Odontogenesis of dentin-containing tooth
Positive regulation of angiogenesis
Positive regulation of apoptotic process
Positive regulation of cell population proliferation
Positive regulation of cytosolic calcium ion concentration
Positive regulation of heart rate
Positive regulation of progesterone biosynthetic process
Positive regulation of vasculogenesis
Receptor internalization
Regulation of systemic arterial blood pressure
Regulation of the force of heart contraction
Regulation of urine volume
Response to cold
Response to glucocorticoid
Response to hypoxia
Response to insulin
Response to lipopolysaccharide
Response to starvation
Response to wounding
Signal transduction
Spongiotrophoblast layer development
Vascular associated smooth muscle cell development
Vasculogenesis

Cellular Location

Secreted

Hupf, J., Mustroph, J., Hanses, F., Evert, K., Maier, L. S., & Jungbauer, C. G. (2020). RNA-expression of adrenomedullin is increased in patients with severe COVID-19. Critical Care, 24(1), 1-3.

Wilson, D. C., Schefold, J. C., Baldirà, J., Spinetti, T., Saeed, K., & Elke, G. (2020). Adrenomedullin in COVID-19 induced endotheliitis. Critical care, 24(1), 1-2.

Paré, M., Darini, C. Y., Yao, X., Chignon-Sicard, B., Rekima, S., Lachambre, S., ... & Ladoux, A. (2020). Breast cancer mammospheres secrete Adrenomedullin to induce lipolysis and browning of adjacent adipocytes. BMC cancer, 20(1), 1-15.

Lundberg, O. H., Lengquist, M., Spångfors, M., Annborn, M., Bergmann, D., Schulte, J., ... & Friberg, H. (2020). Circulating bioactive adrenomedullin as a marker of sepsis, septic shock and critical illness. Critical Care, 24(1), 1-10.

Ma, F., Chen, G., Rodriguez, E. L., Klein, J. D., Sands, J. M., & Wang, Y. (2020). Adrenomedullin inhibits osmotic water permeability in rat inner medullary collecting ducts. Cells, 9(12), 2533.

Voors, A. A., Kremer, D., Geven, C., Ter Maaten, J. M., Struck, J., Bergmann, A., ... & Butler, J. (2019). Adrenomedullin in heart failure: pathophysiology and therapeutic application. European journal of heart failure, 21(2), 163-171.

Ter Maaten, J. M., Kremer, D., Demissei, B. G., Struck, J., Bergmann, A., Anker, S. D., ... & Voors, A. A. (2019). Bio‐adrenomedullin as a marker of congestion in patients with new‐onset and worsening heart failure. European journal of heart failure, 21(6), 732-743.

Kim, H., Hur, M., Struck, J., Bergmann, A., & Di Somma, S. (2019). Circulating biologically active adrenomedullin predicts organ failure and mortality in sepsis. Annals of laboratory medicine, 39(5), 454-463.

Mebazaa, A., Geven, C., Hollinger, A., Wittebole, X., Chousterman, B. G., Blet, A., ... & Laterre, P. F. (2018). Circulating adrenomedullin estimates survival and reversibility of organ failure in sepsis: the prospective observational multinational Adrenomedullin and Outcome in Sepsis and Septic Shock-1 (AdrenOSS-1) study. Critical care, 22(1), 1-12.

Caironi, P., Latini, R., Struck, J., Hartmann, O., Bergmann, A., Maggio, G., ... & Spanuth, E. (2017). Circulating biologically active adrenomedullin (bio-ADM) predicts hemodynamic support requirement and mortality during sepsis. Chest, 152(2), 312-320.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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