Human Recombinant CCL11 protein, His Tag (V2LY-0526-LY3849)

Name: Human Recombinant CCL11 protein, His Tag
SKU: V2LY-0526-LY3849
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

E. coli

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant CCL11 protein, His Tag consist of Amino Acid: 24-97 and predicts a molecular mass of 10.8 kDa.

Molecule Mass

10.8 kDa

Sequence

Amino Acid: 24-97

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>97% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

chemokine (C-C motif) ligand 11

Function

In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions (PubMed:8597956).
Binds to CCR3 (PubMed:8631813).

Biological Process

Actin filament organization Source: Ensembl
Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Branching involved in mammary gland duct morphogenesis Source: Ensembl
Cell adhesion Source: ProtInc
Cellular calcium ion homeostasis Source: ProtInc
Cellular response to interferon-gamma Source: GO_Central
Cellular response to interleukin-1 Source: GO_Central
Cellular response to tumor necrosis factor Source: GO_Central
Chemokine-mediated signaling pathway Source: GO_Central
Chemotaxis Source: ProtInc
Chronic inflammatory response Source: Ensembl
Cytokine-mediated signaling pathway Source: Reactome
Cytoskeleton organization Source: UniProtKB
Eosinophil chemotaxis Source: UniProtKB
ERK1 and ERK2 cascade Source: Ensembl
G protein-coupled receptor signaling pathway Source: GO_Central
Inflammatory response Source: GO_Central
Killing of cells of other organism Source: UniProtKB
Learning or memory Source: ARUK-UCL
Lymphocyte chemotaxis Source: GO_Central
Mammary duct terminal end bud growth Source: Ensembl
Mast cell chemotaxis Source: Ensembl
Modulation of age-related behavioral decline Source: ARUK-UCL
Monocyte chemotaxis Source: GO_Central
Negative regulation of neurogenesis Source: ARUK-UCL
Neutrophil chemotaxis Source: GO_Central
Positive regulation of actin filament polymerization Source: BHF-UCL
Positive regulation of angiogenesis Source: Ensembl
Positive regulation of cell migration Source: BHF-UCL
Positive regulation of endothelial cell proliferation Source: BHF-UCL
Positive regulation of ERK1 and ERK2 cascade Source: GO_Central
Positive regulation of GTPase activity Source: BHF-UCL
Protein phosphorylation Source: ProtInc
Regulation of cell shape Source: UniProtKB
Response to interleukin-13 Source: Ensembl
Response to interleukin-4 Source: Ensembl
Response to radiation Source: ProtInc
Response to virus Source: ProtInc
Signal transduction Source: ProtInc

Cellular Location

Secreted

PTM

O-linked glycan consists of a Gal-GalNAc disaccharide which is modified with up to 2 sialic acid residues.

Da Ae Kim, S. J. P., Lee, J. Y., Kim, J. H., Lee, S., Lee, E., Jang, I. Y., ... & Kim, B. J. (2021). Effect of CCL11 on In Vitro Myogenesis and Its Clinical Relevance for Sarcopenia in Older Adults. Endocrinology and Metabolism, 36(2), 455.

Kurogoushi, R., Hasegawa, T., Akazawa, Y., Iwata, K., Sugimoto, A., Yamaguchi-Ueda, K., ... & Iwamoto, T. (2021). Fibroblast growth factor 2 suppresses the expression of CC motif chemokine 11 through the c-Jun N-terminal kinase pathway in human dental pulp-derived mesenchymal stem cells. Experimental and Therapeutic Medicine, 22(6), 1-8.

Jung, H. W., Park, J. H., & Kim, B. J. (2021). Effect of CCL11 on In Vitro Myogenesis and Its Clinical Relevance for Sarcopenia in Older Adults.

Park, S. J., Da Ae Kim, J. Y. L., & Kim, B. J. (2021). In Vitro Effect of CCL11 on Myogenic Differentiation and Its Relevance With Sarcopenia Parameters in Older Adults. Journal of the Endocrine Society, 5(Suppl 1), A234.

Wang, R., & Huang, K. (2020). CCL11 increases the proportion of CD4+ CD25+ Foxp3+ Treg cells and the production of IL‑2 and TGF‑β by CD4+ T cells via the STAT5 signaling pathway. Molecular medicine reports, 21(6), 2522-2532.

Wang, W., Huang, C. Y., Wang, Z. P., Xu, S. S., Qian, T. Y., Chen, Y. D., & Wu, W. G. (2019). Serum CC motif ligand 11/eotaxin-1 may serve as a candidate biomarker for postmenopausal osteoporosis. Journal of medical biochemistry, 38(3), 353.

Kuznik, B. I., Davydov, S. O., Stepanov, A. V., Guseva, E. S., Smolyakov, Y. N., Tsybikov, N. N., & Magen, E. (2018). The role of growth differentiation factors 11 and 15 (GDF11, GDF15), eotaxin 1 (CCL11) and junctional adhesion molecule a (JAMA) in the regulation of blood pressure in women with essential hypertension. MOJ Gerontology & Geriatrics, 3(1), 71-75.

Polacchini, A., Girardi, D., Falco, A., Zanotta, N., Comar, M., De Carlo, N. A., & Tongiorgi, E. (2018). Distinct CCL2, CCL5, CCL11, CCL27, IL-17, IL-6, BDNF serum profiles correlate to different job-stress outcomes. Neurobiology of stress, 8, 82-91.

Kang, W. S., Kim, Y. J., Park, H. J., Kim, S. K., Paik, J. W., & Kim, J. W. (2018). Association of CCL11 promoter polymorphisms with schizophrenia in a Korean population. Gene, 656, 80-85.

Nieh, S. (2017). The role of cancer-associated fibroblast-induced chemokine ligand 11 in tumor microenvironment contributes to the progression of oral cancer.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Horse CCL11 ELISA Kit (CAT#: V2LY-0626-LY443)

Rat Ccl11 ELISA Kit (CAT#: V2LY-0626-LY961)

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Mouse Anti-CCL11 Recombinant Antibody (CBXC-0108) (CAT#: CBMAB-C5123-CQ)

Horse CCL11 ELISA Kit (CAT#: V2LY-0626-LY443)

Mouse Anti-CCL11 Recombinant Antibody (C1292) (CAT#: CBMAB-C1292-LY)

Rat Anti-CCL11 Recombinant Antibody (CBFYC-0921) (CAT#: CBMAB-C0977-FY)

Mouse Anti-CCL11 Recombinant Antibody (C1291) (CAT#: CBMAB-C1291-LY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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