Human Recombinant CCL18 protein, His Tag (V2LY-0526-LY2626)

Name: Human Recombinant CCL18 protein, His Tag
SKU: V2LY-0526-LY2626
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Yeast

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant CCL18 protein, His Tag consist of Amino Acid: 21-89 and predicts a molecular mass of 9.2 kDa.

Molecule Mass

9.2 kDa

Sequence

Amino Acid: 21-89

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>95% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile Sodium phosphate, NaCl, Imidazole, PMSF, DTT, Glycerol

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)

Function

Chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. May be involved in B-cell migration into B-cell follicles in lymph nodes. Attracts naive T-lymphocytes toward dendritic cells and activated macrophages in lymph nodes, has chemotactic activity for naive T-cells, CD4+ and CD8+ T-cells and thus may play a role in both humoral and cell-mediated immunity responses.

Biological Process

Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Cell-cell signaling Source: ProtInc
Cell communication Source: ProtInc
Cellular response to interferon-gamma Source: GO_Central
Cellular response to interleukin-1 Source: GO_Central
Cellular response to tumor necrosis factor Source: GO_Central
Chemokine-mediated signaling pathway Source: GO_Central
Chemotaxis Source: ProtInc
G protein-coupled receptor signaling pathway Source: GO_Central
Immune response Source: ProtInc
Inflammatory response Source: GO_Central
Killing of cells of other organism Source: UniProtKB
Lymphocyte chemotaxis Source: GO_Central
Monocyte chemotaxis Source: GO_Central
Neutrophil chemotaxis Source: GO_Central
Positive regulation of ERK1 and ERK2 cascade Source: GO_Central
Positive regulation of GTPase activity Source: GO_Central
Signal transduction Source: ProtInc

Cellular Location

Secreted

PTM

The Cys-30/Cys-54 disulfide bond is required for activity.

Aravind, A., Palollathil, A., Rex, D. A. B., Kumar, K. M. K., Vijayakumar, M., Shetty, R., ... & Raju, R. (2021). A multi-cellular molecular signaling and functional network map of C–C motif chemokine ligand 18 (CCL18): a chemokine with immunosuppressive and pro-tumor functions. Journal of Cell Communication and Signaling, 1-8.

Sun, Z., Du, C., Xu, P., & Miao, C. (2019). Surgical trauma‐induced CCL18 promotes recruitment of regulatory T cells and colon cancer progression. Journal of cellular physiology, 234(4), 4608-4616.

Ma, L., Wang, H., Li, Z., Geng, X., & Li, M. (2019). Chemokine (CC motif) ligand 18 is highly expressed in glioma tissues and promotes invasion of glioblastoma cells. Journal of cancer research and therapeutics, 15(2), 358.

Huang, H., Li, J., Hu, W. J., Chen, C., Luo, H. Q., Tang, X. D., ... & Li, X. Y. (2019). The serum level of CC chemokine ligand 18 correlates with the prognosis of non-small cell lung cancer. The International journal of biological markers, 34(2), 156-162.

Song, H., Tao, Y., Ni, N., Zhou, X., Xiong, J., Zeng, X., ... & Sun, J. (2018). miR-128 targets the CC chemokine ligand 18 gene (CCL18) in cutaneous malignant melanoma progression. Journal of dermatological science, 91(3), 317-324.

Orekhov, A. N., Nikiforov, N. G., Elizova, N. V., Korobov, G. A., Aladinskaya, A. V., Sobenin, I. A., & Bobryshev, Y. V. (2018). Tumor necrosis factor-α and CC motif chemokine ligand 18 associate with atherosclerotic lipid accumulation in situ and in vitro. Current pharmaceutical design, 24(24), 2883-2889.

Huang, H., Li, J., Hu, W. J., Chen, M. H., Chen, S. S., Chen, C., ... & Li, X. Y. (2018). Positive expression of chemokine (CC Motif) ligand 18 and prognosis in cancer: A meta-analysis. Journal of BU ON.: official journal of the Balkan Union of Oncology, 23(4), 1185-1194.

Yuan, L., Wan, J., Huang, C., Liang, J., Liu, M., Yue, C., & Li, L. (2018). Evaluation of serum CCL18 as a potential biomarker for ovarian cancer. Cancer Biomarkers, 21(1), 97-104.

Bo, S., Donghao, S., Guangqi, K., & Ye, T. (2018). CC Chemokine Ligand 18 Promotes Cell Proliferation and Metastasis of Urothelial Carcinoma via Activating PI3K/mTOR Signaling in Patient with Renal Transplantation. Urologia internationalis, 101(4), 450-458.

Wang, H., Liang, X., Li, M., Tao, X., Tai, S., Fan, Z., ... & Xia, J. (2017). Chemokine (CC motif) ligand 18 upregulates Slug expression to promote stem‐cell like features by activating the mammalian target of rapamycin pathway in oral squamous cell carcinoma. Cancer science, 108(8), 1584-1593.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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