Human Recombinant CCNT2 protein, GST Tag (V2LY-0526-LY3465)

Name: Human Recombinant CCNT2 protein, GST Tag
SKU: V2LY-0526-LY3465
Rating: 5 (1 reviews)

See all CCNT2 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

GST Tag

Protein Construction

This product is Human Recombinant CCNT2 protein, GST Tag consist of Amino Acid: Full Length and predicts a molecular mass of 102 kDa.

Molecule Mass

102 kDa

Sequence

Amino Acid: Full Length

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

Batch dependent.

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

Tris, NaCl

Preservative

None

Storage

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

More Infomation

Target

Full Name

cyclin T2

Function

Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II) (PubMed:9499409, PubMed:15563843).
The activity of this complex is regulated by binding with 7SK snRNA (PubMed:11713533).
Plays a role during muscle differentiation; P-TEFB complex interacts with MYOD1; this tripartite complex promotes the transcriptional activity of MYOD1 through its CDK9-mediated phosphorylation and binds the chromatin of promoters and enhancers of muscle-specific genes; this event correlates with hyperphosphorylation of the CTD domain of RNA pol II (By similarity).
In addition, enhances MYOD1-dependent transcription through interaction with PKN1 (PubMed:16331689).
Involved in early embryo development (By similarity).
(Microbial infection) Promotes transcriptional activation of early and late herpes simplex virus 1/HHV-1 promoters.

Biological Process

Cell cycle Source: UniProtKB-KW
Cell division Source: UniProtKB-KW
Early viral transcription Source: UniProtKB
Late viral transcription Source: UniProtKB
Positive regulation of DNA-templated transcription, elongation Source: GO_Central
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of cyclin-dependent protein serine/threonine kinase activity Source: ProtInc
Regulation of muscle cell differentiation Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Skeletal muscle tissue development Source: Ensembl
snRNA transcription by RNA polymerase II Source: Reactome
Transcription by RNA polymerase II Source: Reactome
Transcription elongation from RNA polymerase II promoter Source: Reactome

Cellular Location

Nucleus; Perinuclear region. Nucleus in differentiating cells.

Tian, R., Guan, X., Qian, H., Wang, L., Shen, Z., Fang, L., & Liu, Z. (2021). Restoration of NRF2 attenuates myocardial ischemia reperfusion injury through mediating microRNA‐29a‐3p/CCNT2 axis. Biofactors.

Xing, L., Ren, J., Guo, X., Qiao, S., & Tian, T. (2020). Decitabine shows anti-acute myeloid leukemia potential via regulating the miR-212-5p/CCNT2 axis. Open Life Sciences, 15(1), 1013-1023.

Chen, X., Zhang, L., Song, Q., & Chen, Z. (2020). MicroRNA-216b regulates cell proliferation, invasion and cycle progression via interaction with cyclin T2 in gastric cancer. Anti-cancer drugs, 31(6), 623-631.

Wang, F., Zhao, Q. H., Liu, J. Z., & Kong, D. L. (2020). MiRNA-188-5p alleviates the progression of osteosarcoma via target degrading CCNT2. Eur Rev Med Pharmacol Sci, 24(1), 29-35.

Ke, S., Li, R. C., Lu, J., Meng, F. K., Feng, Y. K., & Fang, M. H. (2017). MicroRNA-192 regulates cell proliferation and cell cycle transition in acute myeloid leukemia via interaction with CCNT2. International journal of hematology, 106(2), 258-265.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Human Recombinant CCNT2 protein, GST Tag?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-CCNT2 Recombinant Antibody (2128C1a) (CAT#: CBMAB-C0612-LY)

Mouse Anti-CCNT2 Recombinant Antibody (1H3) (CAT#: CBMAB-C4239-LY)

Mouse Anti-CCNT2 Recombinant Antibody (CBFYC-1060) (CAT#: CBMAB-C1117-FY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry