Human Recombinant CDK13 protein, GST Tag (V2LY-0526-LY3024)

Name: Human Recombinant CDK13 protein, GST Tag
SKU: V2LY-0526-LY3024
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

GST Tag

Protein Construction

This product is Human Recombinant CDK13 protein, GST Tag consist of Amino Acid: 516-end and predicts a molecular mass of 160 kDa.

Molecule Mass

160 kDa

Sequence

Amino Acid: 516-end

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

Batch dependent.

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

PBS

Preservative

None

Storage

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

More Infomation

Target

Full Name

Cyclin Dependent Kinase 13

Function

Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef.

Biological Process

Alternative mRNA splicing, via spliceosome Source: UniProtKB
Hemopoiesis Source: UniProtKB
Multicellular organism development Source: ProtInc
Negative regulation of stem cell differentiation Source: Ensembl
Neutrophil degranulation Source: Reactome
Phosphorylation of RNA polymerase II C-terminal domain Source: UniProtKB
Positive regulation of cell population proliferation Source: ProtInc
Positive regulation of transcription elongation from RNA polymerase II promoter Source: GO_Central
Protein phosphorylation Source: GO_Central
Regulation of mitotic nuclear division Source: ProtInc
Transcription elongation from RNA polymerase II promoter Source: GO_Central
Viral process Source: UniProtKB-KW

Cellular Location

Nucleus speckle

Involvement in disease

Congenital heart defects, dysmorphic facial features, and intellectual developmental disorder (CHDFIDD): An autosomal dominant syndrome characterized by atrial and/or ventricular septal congenital heart defects, facial dysmorphism with hypertelorism, upslanted palpebral fissures, epicanthal folds, ptosis, strabismus, posteriorly rotated ears, thin upper lip, and small mouth. Patients manifest global developmental delay, delayed walking and speech acquisition, and intellectual disability. Some patients have mild microcephaly, a small cerebral cortex, and agenesis of corpus callosum. More variable features include clinodactyly and/or camptodactyly of the fingers, hypotonia, and joint hypermobility.

Ramírez-Moya, J., Miliotis, C., Baker, A. R., Gregory, R. I., Slack, F. J., & Santisteban, P. (2021). An ADAR1-dependent RNA editing event in the cyclin-dependent kinase CDK13 promotes thyroid cancer hallmarks. Molecular cancer, 20(1), 1-20.

Wang, J., Zhang, Y., Lu, L., Lu, Y., Tang, Q., & Pu, J. (2019). Insight into the molecular mechanism of LINC00152/miR‐215/CDK13 axis in hepatocellular carcinoma progression. Journal of cellular biochemistry, 120(11), 18816-18825.

Baniya, S. (2019). Validating CDK13 as a Novel Dependency in Acute Myeloid Leukemia (Doctoral dissertation, Wellesley College).

Hamilton, M. J., & Suri, M. (2019). CDK13-related disorder. Advances in genetics, 103, 163-182.

Hampl, M., Novakova, M., Kavkova, M., Zikmund, T., Kohoutek, J., Kaiser, J., & Buchtová, M. (2019). Cdk13-/-Mice Exhibit Developmental Delay and Craniofacial Malformations during Embryonic Development.

Quereda, V., Bayle, S., Vena, F., Frydman, S. M., Monastyrskyi, A., Roush, W. R., & Duckett, D. R. (2019). Therapeutic targeting of CDK12/CDK13 in triple-negative breast cancer. Cancer Cell, 36(5), 545-558.

van den Akker, W. M. R., Brummelman, I., Martis, L. M., Timmermans, R. N., Pfundt, R., Kleefstra, T., ... & Schuurs‐Hoeijmakers, J. H. M. (2018). De novo variants in CDK13 associated with syndromic ID/DD: molecular and clinical delineation of 15 individuals and a further review. Clinical genetics, 93(5), 1000-1007.

Uehara, T., Takenouchi, T., Kosaki, R., Kurosawa, K., Mizuno, S., & Kosaki, K. (2018). Redefining the phenotypic spectrum of de novo heterozygous CDK13 variants: Three patients without cardiac defects. European journal of medical genetics, 61(5), 243-247.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant CDK13 & CCNK, Active protein, GST Tag (CAT#: V2LY-0526-LY3023)

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Isotype control

For research use only. Not intended for any clinical use.

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