Human Recombinant CDK19 protein, GST Tag (V2LY-0526-LY3025)

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Basic Information

Expressed Host
Baculovirus-Insect Cells
Protein Species
Human
Tag
GST Tag
Protein Construction
This product is Human Recombinant CDK19 protein, GST Tag consist of Amino Acid: Full Length and predicts a molecular mass of 92 kDa.
Molecule Mass
92 kDa
Sequence
Amino Acid: Full Length
Species
Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
Batch dependent.
Endotoxin
Please contact us for more information.
Format
Liquid
Buffer
PBS
Preservative
None
Storage
Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
More Infomation

Target

Full Name
Cyclin Dependent Kinase 19
Biological Process
Cellular response to lipopolysaccharide Source: Ensembl
Positive regulation of apoptotic process Source: Ensembl
Positive regulation of inflammatory response Source: Ensembl
Protein phosphorylation Source: GO_Central
Cellular Location
Nucleus; Cytoplasm; Perinuclear region
Involvement in disease
Developmental and epileptic encephalopathy 87 (DEE87): A form of epileptic encephalopathy, a heterogeneous group of severe early-onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. DEE87 inheritance is autosomal dominant.

Cai, X., Deng, J., Cai, H., & Chen, Z. (2021). Cyclin Dependent Kinase 19 Upregulation Correlates With Unfavorable Prognosis in Hepatocellular Carcinoma.

Butler, M., Chotiwan, N., Brewster, C. D., DiLisio, J. E., Ackart, D. F., Podell, B. K., ... & Rovnak, J. (2020). Cyclin-Dependent Kinases 8 and 19 Regulate Host Cell Metabolism during Dengue Virus Serotype 2 Infection. Viruses, 12(6), 654.

Dannappel, M. V., Sooraj, D., Loh, J. J., & Firestein, R. (2019). Molecular and in vivo functions of the CDK8 and CDK19 kinase modules. Frontiers in cell and developmental biology, 6, 171.

Fant, C. B., & Taatjes, D. J. (2019). Regulatory functions of the Mediator kinases CDK8 and CDK19. Transcription, 10(2), 76-90.

Amirhosseini, M., Bernhardsson, M., Lång, P., Andersson, G., Flygare, J., & Fahlgren, A. (2019). Cyclin‐dependent kinase 8/19 inhibition suppresses osteoclastogenesis by downregulating RANK and promotes osteoblast mineralization and cancellous bone healing. Journal of cellular physiology, 234(9), 16503-16516.

Chen, M., Hu, B., Ji, H., Altilia, S., Liang, J., McDermott, M., ... & Roninson, I. (2017). Functional characterization of novel transcription-regulating cancer drug targets, CDK8 and CDK19, using CRISPR/Cas9 knockout and a highly selective CDK8/19 kinase inhibitor.

Audetat, K. A., Galbraith, M. D., Odell, A. T., Lee, T., Pandey, A., Espinosa, J. M., ... & Taatjes, D. J. (2017). A kinase-independent role for cyclin-dependent kinase 19 in p53 response. Molecular and cellular biology, 37(13), e00626-16.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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