Human Recombinant CGB5 protein, His Tag (V2LY-0526-LY3108)

Name: Human Recombinant CGB5 protein, His Tag
SKU: V2LY-0526-LY3108
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant CGB5 protein, His Tag consist of Amino Acid: 1-165 and predicts a molecular mass of 17 kDa.

Molecule Mass

17 kDa

Sequence

Amino Acid: 1-165

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>90% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

chorionic gonadotropin, beta polypeptide 5

Function

Beta subunit of the human chorionic gonadotropin (hCG). hCG is a complex glycoprotein composed of two glycosylated subunits alpha and beta which are non-covalently associated. The alpha subunit is identical to those in the pituitary gonadotropin hormones (LH, FSH and TSH). The beta subunits are distinct in each of the hormones and confer receptor and biological specificity. Has an essential role in pregnancy and maternal adaptation. Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy.

Biological Process

Apoptotic process Source: ProtInc
Cell-cell signaling Source: ProtInc
Female gamete generation Source: ProtInc
G protein-coupled receptor signaling pathway Source: GO_Central
Hormone-mediated signaling pathway Source: GO_Central
Peptide hormone processing Source: Reactome
Regulation of transcription by RNA polymerase II Source: Reactome
Signal transduction Source: ProtInc

Cellular Location

Secreted

Biskup, K., Blanchard, V., Castillo-Binder, P., Alexander, H., Engeland, K., & Schug, S. (2020). N-and O-glycosylation patterns and functional testing of CGB7 versus CGB3/5/8 variants of the human chorionic gonadotropin (hCG) beta subunit. Glycoconjugate journal, 37(5), 599-610.

Śliwa, A., Kubiczak, M., Szczerba, A., Walkowiak, G., Nowak-Markwitz, E., Burczyńska, B., ... & Jankowska, A. (2019). Regulation of human chorionic gonadotropin beta subunit expression in ovarian cancer. BMC cancer, 19(1), 1-9.

Lintula, S., Mirtti, T., Rannikko, A., Bützow, A., Lempiäinen, A., Stenman, J., ... & Hotakainen, K. (2019). Tumor expression of human chorionic gonadotropin beta mRNA and prognosis of prostate cancer treated by radical prostatectomy. Scandinavian journal of clinical and laboratory investigation, 79(6), 424-430.

Yang, Y., Shi, Y., Hou, Y., Lu, Y., & Yang, J. (2018). CGB 5 expression is independently associated with poor overall survival and recurrence‐free survival in patients with advanced gastric cancer. Cancer medicine, 7(3), 716-725.

Babaei Houlari, B., & Salehi, Z. (2018). Analysis of the Relationship between CGB5 155G/C Polymorphism and in vitro Fertilization-embryo Transfer Outcome (IVF-ET) in the Iranian Population. Journal of Arak University of Medical Sciences, 20(10), 11-19.

Andrusiewicz, M., Skibińska, I., Gąsiorowska, E., Białas, P., & Kotwicka, M. (2017). Fluorescence resonance energy transfer usage to track the sequence promoter changes in CGB5 gene in ovarian cancer patients. Biomedicine & Pharmacotherapy, 90, 139-146.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant CGB5 protein, Fc Tag (CAT#: V2LY-0526-LY3109)

Related Products

Mouse Anti-CGB5 Recombinant Antibody (CBFYH-0101) (CAT#: CBMAB-H0516-FY)

Human Recombinant CGB5 protein, Fc Tag (CAT#: V2LY-0526-LY3109)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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