CGB5

This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 5 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene. [provided by RefSeq]

Full Name

chorionic gonadotropin, beta polypeptide 5

Function

Beta subunit of the human chorionic gonadotropin (hCG). hCG is a complex glycoprotein composed of two glycosylated subunits alpha and beta which are non-covalently associated. The alpha subunit is identical to those in the pituitary gonadotropin hormones (LH, FSH and TSH). The beta subunits are distinct in each of the hormones and confer receptor and biological specificity. Has an essential role in pregnancy and maternal adaptation. Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy.

Biological Process

Apoptotic process Source: ProtInc
Cell-cell signaling Source: ProtInc
Female gamete generation Source: ProtInc
G protein-coupled receptor signaling pathway Source: GO_Central
Hormone-mediated signaling pathway Source: GO_Central
Peptide hormone processing Source: Reactome
Regulation of transcription by RNA polymerase II Source: Reactome
Signal transduction Source: ProtInc

Cellular Location

Secreted