Human Recombinant CKB protein, His Tag (V2LY-0526-LY3367)

Name: Human Recombinant CKB protein, His Tag
SKU: V2LY-0526-LY3367
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant CKB protein, His Tag consist of Amino Acid: 2-381 and predicts a molecular mass of 44.8 kDa.

Molecule Mass

44.8 kDa

Sequence

Amino Acid: 2-381

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>90% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

Tris, NaCl, Glycerol, TCEP

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Creatine Kinase B

Function

Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.

Biological Process

Cellular chloride ion homeostasis Source: Ensembl
Cerebellum development Source: Ensembl
Creatine metabolic process Source: Reactome
Phosphocreatine biosynthetic process Source: GO_Central
Substantia nigra development Source: UniProtKB

Cellular Location

Cytoplasm

Rahbani, J. F., Roesler, A., Hussain, M. F., Samborska, B., Dykstra, C. B., Tsai, L., ... & Kazak, L. (2021). Creatine kinase B controls futile creatine cycling in thermogenic fat. Nature, 590(7846), 480-485.

Krutilina, R. I., Playa, H. C., Brooks, D. L., Schwab, L. P., Parke, D. N., Oluwalana, D., ... & Seagroves, T. N. (2021). HIF-dependent expression of creatine kinase brain isoform (CKB) promotes breast cancer metastasis, and blocking creatine kinase activity with cyclocreatine impairs invasion and improves the efficacy of conventional chemotherapies. bioRxiv.

Sprenger, J., Trifan, A., Patel, N., Vanderbeck, A., Bredfelt, J., Tajkhorshid, E., ... & Linse, S. (2021). Calmodulin complexes with brain and muscle creatine kinase peptides. Current Research in Structural Biology, 3, 121-132.

Jeong, Y. J., Park, S. W., Seo, M. K., Kim, S. J., Lee, W. H., Kim, M., ... & Seog, D. H. (2021). The Heterotrimeric Kinesin-2 Family Member KIF3A Directly Binds to Creatine Kinase B. Journal of Life Science, 31(3), 257-265.

Vallecillo, R. (2021). Determining the Role of Brain-Type Creatine Kinase in the Lungs During Asthma.

Sun, X. B., Lim, G. T., Lee, J., Wan, J. X., Lin, H. Z., Yang, J. M., ... & Park, Y. D. (2018). Effects of osmolytes on the refolding of recombinant Pelodiscus sinensis brain-type creatine kinase. Process Biochemistry, 68, 83-92.

Hwang, J. H. (2017). Effects of obesity on protein kinase C, brain creatine kinase, transcription, and autophagy in cochlea. Metabolic brain disease, 32(3), 735-742.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant CKB protein (CAT#: V2LY-0526-LY3366)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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