Human Recombinant CTSV protein, His Tag (V2LY-0526-LY2610)

Name: Human Recombinant CTSV protein, His Tag
SKU: V2LY-0526-LY2610
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant CTSV protein, His Tag consist of Amino Acid: 1-334 and predicts a molecular mass of 37.1 kDa.

Molecule Mass

37.1 kDa

Verified

HPLC

Sequence

Amino Acid: 1-334

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥95% as determined by SDS-PAGE. ≥95% as determined by SEC-HPLC.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Cathepsin V

Function

Cysteine protease. May have an important role in corneal physiology.

Biological Process

Antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
Extracellular matrix disassembly Source: Reactome
Immune response Source: GO_Central
Proteolysis involved in cellular protein catabolic process Source: GO_Central
Regulation of keratinocyte differentiation Source: Reactome

Cellular Location

Lysosome

Lin, C. L., Hung, T. W., Ying, T. H., Lin, C. J., Hsieh, Y. H., & Chen, C. M. (2020). Praeruptorin B mitigates the metastatic ability of human renal carcinoma cells through targeting CTSC and CTSV expression. International journal of molecular sciences, 21(8), 2919.

Toss, M., Miligy, I., Gorringe, K., Mittal, K., Aneja, R., Ellis, I., ... & Rakha, E. (2020). Prognostic significance of cathepsin V (CTSV/CTSL2) in breast ductal carcinoma in situ. Journal of Clinical Pathology, 73(2), 76-82.

Wang, C. H., Wang, L. K., Wu, C. C., Chen, M. L., Kuo, C. Y., Shyu, R. Y., & Tsai, F. M. (2020). Cathepsin V Mediates the Tazarotene-induced Gene 1-induced Reduction in Invasion in Colorectal Cancer Cells. Cell Biochemistry and Biophysics, 78(4), 483-494.

Matsukawa, S., Sumigama, S., Kotani, T., Wang, J., Miki, R., Moriyama, Y., ... & Kikkawa, F. (2019). Possible association between cathepsin V and the development of placenta accreta spectrum disorders. Gynecologic and Obstetric Investigation, 84(4), 396-406.

Homma, T., Kageyama, S., Nishikawa, A., & Nagata, K. (2018). Melanosome degradation in epidermal keratinocytes related to lysosomal protease cathepsin V. Biochemical and biophysical research communications, 500(2), 339-343.

Podvin, S., Wojnicz, A., & Hook, V. (2018). Human brain gene expression profiles of the cathepsin V and cathepsin L cysteine proteases, with the PC1/3 and PC2 serine proteases, involved in neuropeptide production. Heliyon, 4(7), e00673.

Huang, K., Gao, L., Yang, M., Wang, J., Wang, Z., Wang, L., ... & Li, H. (2017). Exogenous cathepsin V protein protects human cardiomyocytes HCM from angiotensin Ⅱ-Induced hypertrophy. The International Journal of Biochemistry & Cell Biology, 89, 6-15.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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