Sign in or Register
  • Home
  • CTSV
  • Mouse Anti-CTSV Recombinant Antibody (CBXC-0622)

Mouse Anti-CTSV Recombinant Antibody (CBXC-0622) (V2LY-0125-LY487)

See all CTSV antibodies
Go to compare Compare Online Inquiry
Published Data
V2LY-0125-LY487-1
Mouse Anti-CTSV Recombinant Antibody (CBXC-0622) (V2LY-0125-LY487) in IF
Immunohistochemistry of cysteine cathepsin V in human thyroid tissue. Human thyroid tissue sections were immunolabeled with different cathepsin V-specific antibodies (green signals), namely, anti-human cathepsin V CV55 1C5 (A,B) that exclusively immunoreacts with the proform of cathepsin V, and anti-human cathepsin V MAB1080 (C,D) recognizing both the pro- and mature cathepsin V forms. Nuclei were counter-stained with Draq5™ (blue signals). Single-channel fluorescence and corresponding phase contrast micrographs are depicted as indicated. Cathepsin V-immunopositive signals were detected within the cytoplasm (arrowheads), at the apical plasma membrane (arrows), and dispersed within the follicle lumen (asterisks). Rectangular boxes in A and C denote regions magnified in B and D, respectively. Scale bars represent 50 μm. ...View More
Al-Hashimi, A., Venugopalan, V., Rehders, M., Sereesongsaeng, N., Hein, Z., Springer, S., ... & Brix, K. (2020). Procathepsin V is secreted in a TSH regulated manner from human thyroid epithelial cells and is accessible to an activity-based probe. International Journal of Molecular Sciences, 21(23), 9140. Distributed under Open Access license CC BY 4.0, without modification.
V2LY-0125-LY487-2
Mouse Anti-CTSV Recombinant Antibody (CBXC-0622) (V2LY-0125-LY487) in IF
Subcellular localization of endogenous cathepsin V and eGFP-tagged full-length cathepsin V chimeric protein in thyroid epithelial cells. Non-transduced Nthy-ori 3-1 (A,B) and transduced Nthyori-CV cells (C-E) were immunostained with different cathepsin V antibodies (red signals), i.e., anti-human cathepsin V CV55-1C5 that exclusively immunodetects the proform of cathepsin V (A,D) and anti-human cathepsin V MAB1080 recognizing both, the pro- and mature cathepsin V forms (B,E). Green channels (C-E) represent fluorescence signals of hCV-eGFP. Yellow signals are indicative of colocalizing signals from cathepsin V antibodies and hCV-eGFP. The sketch (upper left panel) outlines this approach schematically. Nuclei were counter-stained with Draq5™ (blue signals). Pink signals are indicative of colocalizing signals from cathepsin V antibodies and nuclear Draq5™ staining. Single-channel fluorescence and corresponding phase contrast micrographs are depicted as indicated. Arrowheads denote immunoreactive and hCV-eGFP-derived signals at the cell surface, while arrows point to vesicular hCV-eGFP signals in Nthyori-CV cells. Scale bars represent 50 μm. ...View More
Al-Hashimi, A., Venugopalan, V., Rehders, M., Sereesongsaeng, N., Hein, Z., Springer, S., ... & Brix, K. (2020). Procathepsin V is secreted in a TSH regulated manner from human thyroid epithelial cells and is accessible to an activity-based probe. International Journal of Molecular Sciences, 21(23), 9140. Distributed under Open Access license CC BY 4.0, without modification.
Datasheet
SDS
Request for COA
Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Mouse
Clone
CBXC-0622
Application
WB, IHC, IP
Immunogen
Recombinant human Cathepsin V.
Host Species
Mouse
Specificity
Human, Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1 μg/mL
IP25 μg/mL
IHC8-25 μg/mL

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS & Trehalose
Preservative
None
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
Cathepsin V
Entrez Gene ID
1515
UniProt ID
O60911
Function
Cysteine protease. May have an important role in corneal physiology.
Biological Process
Antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
Extracellular matrix disassembly Source: Reactome
Immune response Source: GO_Central
Proteolysis involved in cellular protein catabolic process Source: GO_Central
Regulation of keratinocyte differentiation Source: Reactome
Cellular Location
Lysosome

Lin, C. L., Hung, T. W., Ying, T. H., Lin, C. J., Hsieh, Y. H., & Chen, C. M. (2020). Praeruptorin B mitigates the metastatic ability of human renal carcinoma cells through targeting CTSC and CTSV expression. International journal of molecular sciences, 21(8), 2919.

Toss, M., Miligy, I., Gorringe, K., Mittal, K., Aneja, R., Ellis, I., ... & Rakha, E. (2020). Prognostic significance of cathepsin V (CTSV/CTSL2) in breast ductal carcinoma in situ. Journal of Clinical Pathology, 73(2), 76-82.

Wang, C. H., Wang, L. K., Wu, C. C., Chen, M. L., Kuo, C. Y., Shyu, R. Y., & Tsai, F. M. (2020). Cathepsin V Mediates the Tazarotene-induced Gene 1-induced Reduction in Invasion in Colorectal Cancer Cells. Cell Biochemistry and Biophysics, 78(4), 483-494.

Matsukawa, S., Sumigama, S., Kotani, T., Wang, J., Miki, R., Moriyama, Y., ... & Kikkawa, F. (2019). Possible association between cathepsin V and the development of placenta accreta spectrum disorders. Gynecologic and Obstetric Investigation, 84(4), 396-406.

Homma, T., Kageyama, S., Nishikawa, A., & Nagata, K. (2018). Melanosome degradation in epidermal keratinocytes related to lysosomal protease cathepsin V. Biochemical and biophysical research communications, 500(2), 339-343.

Podvin, S., Wojnicz, A., & Hook, V. (2018). Human brain gene expression profiles of the cathepsin V and cathepsin L cysteine proteases, with the PC1/3 and PC2 serine proteases, involved in neuropeptide production. Heliyon, 4(7), e00673.

Huang, K., Gao, L., Yang, M., Wang, J., Wang, Z., Wang, L., ... & Li, H. (2017). Exogenous cathepsin V protein protects human cardiomyocytes HCM from angiotensin Ⅱ-Induced hypertrophy. The International Journal of Biochemistry & Cell Biology, 89, 6-15.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-CTSV Recombinant Antibody (CBXC-0622)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-CTSV Recombinant Antibody (CBWJC-3438) (CAT#: V2LY-0125-LY488)

Mouse Anti-CTSV Recombinant Antibody (CBYY-C2327) (CAT#: V2LY-0125-LY486)

Mouse Anti-CTSV Recombinant Antibody (CBFYC-2462) (CAT#: V2LY-0125-LY485)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry
Request bulk or custom quote Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

online inquiry
Online Inquiry