Human Recombinant DCLK1 protein (V2LY-0526-LY3497)

Name: Human Recombinant DCLK1 protein
SKU: V2LY-0526-LY3497
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Protein Construction

This product is Human Recombinant DCLK1 protein consist of Amino Acid: 1-705 and predicts a molecular mass of 78.5 kDa.

Molecule Mass

78.5 kDa

Sequence

Amino Acid: 1-705

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>80% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Doublecortin Like Kinase 1

Function

Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system.

Biological Process

Axon extension Source: Ensembl
Central nervous system development Source: ProtInc
Central nervous system projection neuron axonogenesis Source: Ensembl
Dendrite morphogenesis Source: Ensembl
Endosomal transport Source: UniProtKB
Forebrain development Source: Ensembl
Intracellular signal transduction Source: InterPro
Negative regulation of protein localization to nucleus Source: Ensembl
Nervous system development Source: ProtInc
Neuron migration Source: Ensembl
Neuron projection morphogenesis Source: GO_Central
Peptidyl-serine phosphorylation Source: Ensembl
Protein phosphorylation Source: ProtInc
Response to virus Source: UniProtKB

Cellular Location

Integral component of plasma membrane; Postsynaptic density

Patel, O., Roy, M. J., Kropp, A., Hardy, J. M., Dai, W., & Lucet, I. S. (2021). Structural basis for small molecule targeting of Doublecortin Like Kinase 1 with DCLK1-IN-1. Communications biology, 4(1), 1-13.

Agulto, R. L., Rogers, M. M., Tan, T. C., Ramkumar, A., Downing, A. M., Bodin, H., ... & Ori-McKenney, K. M. (2021). Autoregulatory control of microtubule binding in doublecortin-like kinase 1. Elife, 10, e60126.

Onisha, P., Roy, M. J., Ashleigh, K., Hardy, J. M., Weiwen, D., & Lucet, I. S. (2021). Structural basis for small molecule targeting of Doublecortin Like Kinase 1 with DCLK1-IN-1. Communications Biology, 4(1).

Ferguson, F. M., Nabet, B., Raghavan, S., Liu, Y., Leggett, A. L., Kuljanin, M., ... & Gray, N. S. (2020). Discovery of a selective inhibitor of doublecortin like kinase 1. Nature chemical biology, 16(6), 635-643.

Vázquez-Vélez, G. E., Gonzales, K. A., Revelli, J. P., Adamski, C. J., Naini, F. A., Bajić, A., ... & Zoghbi, H. Y. (2020). Doublecortin-like kinase 1 regulates α-synuclein levels and toxicity. Journal of Neuroscience, 40(2), 459-477.

Wang, J., Wang, S., Zhou, J., & Qian, Q. (2018). miR-424-5p regulates cell proliferation, migration and invasion by targeting doublecortin-like kinase 1 in basal-like breast cancer. Biomedicine & Pharmacotherapy, 102, 147-152.

Li, J., Wang, Y., Ge, J., Li, W., Yin, L., Zhao, Z., ... & Wang, H. (2018). Doublecortin-like kinase 1 (DCLK1) regulates B cell-specific moloney murine leukemia virus insertion site 1 (Bmi-1) and is associated with metastasis and prognosis in pancreatic cancer. Cellular Physiology and Biochemistry, 51(1), 262-277.

Fan, M., Qian, N., & Dai, G. (2017). Expression and prognostic significance of doublecortin‑like kinase 1 in patients with hepatocellular carcinoma. Oncology Letters, 14(6), 7529-7537.

Westphalen, C. B., Quante, M., & Wang, T. C. (2017). Functional implication of Dclk1 and Dclk1-expressing cells in cancer. Small GTPases, 8(3), 164-171.

Wu, X., Ruan, Y., Jiang, H., & Xu, C. (2017). MicroRNA-424 inhibits cell migration, invasion, and epithelial mesenchymal transition by downregulating doublecortin-like kinase 1 in ovarian clear cell carcinoma. The International Journal of Biochemistry & Cell Biology, 85, 66-74.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant DCLK1 protein, GST Tag (CAT#: V2LY-0526-LY3498)

Human Recombinant DCLK1, Active protein, GST Tag (CAT#: V2LY-0526-LY3499)

Human Recombinant DCLK1, Active protein, His Tag (CAT#: V2LY-0526-LY3500)

Human Recombinant DCLK1, Active protein, GST Tag-1 (CAT#: V2LY-0526-LY3501)

Mouse Dclk1 ELISA Kit (CAT#: V2LY-0626-LY2302)

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Mouse Anti-DCLK1 Recombinant Antibody (CBYCD-540) (CAT#: CBMAB-D0362-YC)

Human Recombinant DCLK1 protein, GST Tag (CAT#: V2LY-0526-LY3498)

Human Recombinant DCLK1, Active protein, GST Tag (CAT#: V2LY-0526-LY3499)

Mouse Anti-DCLK1 Recombinant Antibody (6H4) (CAT#: CBMAB-D0361-YC)

Mouse Anti-DCLK1 Recombinant Antibody (10) (CAT#: CBMAB-A2102-LY)

Human Recombinant DCLK1, Active protein, GST Tag-1 (CAT#: V2LY-0526-LY3501)

Mouse Anti-DCLK1 Recombinant Antibody (D0356) (CAT#: V2LY-0125-LY1196)

Mouse Dclk1 ELISA Kit (CAT#: V2LY-0626-LY2302)

Human Recombinant DCLK1, Active protein, His Tag (CAT#: V2LY-0526-LY3500)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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