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DCLK1

This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.[provided by RefSeq, Sep 2010]

Full Name

Doublecortin Like Kinase 1

Function

Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system.

Biological Process

Axon extension Source: Ensembl
Central nervous system development Source: ProtInc
Central nervous system projection neuron axonogenesis Source: Ensembl
Dendrite morphogenesis Source: Ensembl
Endosomal transport Source: UniProtKB
Forebrain development Source: Ensembl
Intracellular signal transduction Source: InterPro
Negative regulation of protein localization to nucleus Source: Ensembl
Nervous system development Source: ProtInc
Neuron migration Source: Ensembl
Neuron projection morphogenesis Source: GO_Central
Peptidyl-serine phosphorylation Source: Ensembl
Protein phosphorylation Source: ProtInc
Response to virus Source: UniProtKB

Cellular Location

Integral component of plasma membrane; Postsynaptic density

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Anti-DCLK1 antibodies

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Mouse Anti-DCLK1 Recombinant Antibody (10) (CBMAB-A2102-LY)

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Target: DCLK1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 10

Application*: E

Mouse Anti-DCLK1 Recombinant Antibody (A2101) (CBMAB-A2101-LY)

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Target: DCLK1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Pig

Clone: A2101

Application*: IH, IF, WB

Mouse Anti-DCLK1 Recombinant Antibody (CBYCD-540) (CBMAB-D0362-YC)

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Target: DCLK1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBYCD-540

Application*: IH, IF, WB

Mouse Anti-DCLK1 Recombinant Antibody (6H4) (CBMAB-D0361-YC)

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Target: DCLK1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse

Clone: 6H4

Application*: E, IF, WB

Mouse Anti-DCLK1 Recombinant Antibody (6F9) (CBMAB-D0355-YC)

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Target: DCLK1

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human, Mouse

Clone: 6F9

Application*: E, WB

Mouse Dclk1 ELISA Kit (V2LY-0626-LY2302)

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Target: Dclk1

Sensitivity: 0.016 ng/mL

Detection Range: 0.03-7 ng/mL

Sample Type: Serum, Plasma, cell culture supernates

Specificity: Mouse

Assay Type: Sandwich

Reactivity: Mouse

Human Recombinant DCLK1, Active protein, GST Tag-1 (V2LY-0526-LY3501)

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Target: DCLK1

Expressed Host: Baculovirus-Insect Cells

Sequence: Amino Acid: 266-end

Tag: GST Tag

Human Recombinant DCLK1, Active protein, His Tag (V2LY-0526-LY3500)

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Target: DCLK1

Expressed Host: Baculovirus-Insect Cells

Sequence: Amino Acid: Full Length

Tag: His Tag

Human Recombinant DCLK1, Active protein, GST Tag (V2LY-0526-LY3499)

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Target: DCLK1

Expressed Host: Baculovirus-Insect Cells

Sequence: Amino Acid: Full Length

Tag: GST Tag

Human Recombinant DCLK1 protein, GST Tag (V2LY-0526-LY3498)

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Target: DCLK1

Expressed Host: Baculovirus-Insect Cells

Sequence: Amino Acid: 1-705

Tag: GST Tag

Human Recombinant DCLK1 protein (V2LY-0526-LY3497)

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Target: DCLK1

Expressed Host: Baculovirus-Insect Cells

Sequence: Amino Acid: 1-705

Mouse Anti-DCLK1 Recombinant Antibody (D0356) (V2LY-0125-LY1196)

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Target: DCLK1

Host: Mouse

Antibody Isotype: IgM, κ

Specificity: Human, Mouse, Rat

Clone: D0356

Application*: WB, IP, IF, E

Rabbit Anti-DCLK1 Monoclonal Antibody (0987) (V2LY-0125-LY1194)

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Target: DCLK1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: 0987

Application*: WB, P

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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