Human Recombinant FABP5 protein (V2LY-0526-LY3982)

Name: Human Recombinant FABP5 protein
SKU: V2LY-0526-LY3982
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

E. coli

Protein Species

Human

Protein Construction

This product is Human Recombinant FABP5 protein consist of Amino Acid: 1-135 and predicts a molecular mass of 15.2 kDa.

Molecule Mass

15.2 kDa

Sequence

Amino Acid: 1-135

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>92% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile Sodium Citrate, NaCl, Tween80

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Fatty Acid Binding Protein 5

Research Area

Intracellular carrier for long-chain fatty acids and related active lipids, such as endocannabinoids, that regulate the metabolism and actions of the ligands they bind. In addition to the cytosolic transport, selectively delivers specific fatty acids from the cytosol to the nucleus, wherein they activate nuclear receptors (PubMed:22170058, PubMed:21395585).

Delivers retinoic acid to the nuclear receptor peroxisome proliferator-activated receptor delta; which promotes proliferation and survival. May also serve as a synaptic carrier of endocannabinoid at central synapses and thus controls retrograde endocannabinoid signaling. Modulates inflammation by regulating PTGES induction via NF-kappa-B activation, and prostaglandin E2 (PGE2) biosynthesis during inflammation (By similarity).

May be involved in keratinocyte differentiation (PubMed:8092987).

Biological Process

Epidermis development Source: ProtInc
Glucose homeostasis Source: Ensembl
Glucose metabolic process Source: Ensembl
Lipid metabolic process Source: ProtInc
Lipid transport across blood-brain barrier Source: ARUK-UCL
Long-chain fatty acid transport Source: ARUK-UCL
Negative regulation of glucose transmembrane transport Source: Ensembl
Phosphatidylcholine biosynthetic process Source: Ensembl
Positive regulation of cold-induced thermogenesis Source: YuBioLab
Positive regulation of peroxisome proliferator activated receptor signaling pathway Source: Ensembl
Regulation of prostaglandin biosynthetic process Source: Ensembl
Regulation of retrograde trans-synaptic signaling by endocanabinoid Source: UniProtKB
Regulation of sensory perception of pain Source: Ensembl

Cellular Location

Secreted; Cytoplasm; Nucleus; Synapse; Postsynaptic density. Localizes primarily to the cytoplasm. Upon certain ligand binding, a conformation change exposes a nuclear localization motif and the protein is transported into nucleus (PubMed:24692551). Secreted by astrocytes, but not by neurons (By similarity).

Li, R., Liang, Y., & Lin, B. (2022). Accumulation of systematic TPM1 mediates inflammation and neuronal remodeling by phosphorylating PKA and regulating the FABP5/NF‐κB signaling pathway in the retina of aged mice. Aging Cell, 21(3), e13566.

Wang, W., Liu, Z., Chen, X., Lu, Y., Wang, B., Li, F., ... & Zhou, X. (2021). Downregulation of FABP5 Suppresses the Proliferation and Induces the Apoptosis of Gastric Cancer Cells Through the Hippo Signaling Pathway. DNA and Cell Biology, 40(8), 1076-1086.

Guo, Y., Liu, Y., Zhao, S., Xu, W., Li, Y., Zhao, P., ... & Zhang, X. (2021). Oxidative stress-induced FABP5 S-glutathionylation protects against acute lung injury by suppressing inflammation in macrophages. Nature Communications, 12(1), 1-18.

Seo, J., Jeong, D. W., Park, J. W., Lee, K. W., Fukuda, J., & Chun, Y. S. (2020). Fatty-acid-induced FABP5/HIF-1 reprograms lipid metabolism and enhances the proliferation of liver cancer cells. Communications biology, 3(1), 1-14.

O'Sullivan, S. E., & Kaczocha, M. (2020). FABP5 as a novel molecular target in prostate cancer. Drug discovery today, 25(11), 2056-2061.

Zhang, C., Liao, Y., Liu, P., Du, Q., Liang, Y., Ooi, S., ... & Wang, W. (2020). FABP5 promotes lymph node metastasis in cervical cancer by reprogramming fatty acid metabolism. Theranostics, 10(15), 6561.

Chen, J., Liu, X., Zhang, S., Chen, J., Sun, H., Zhang, L., & Zhang, Q. (2020). Molecular mechanism with regard to the binding selectivity of inhibitors toward FABP5 and FABP7 explored by multiple short molecular dynamics simulations and free energy analyses. Physical Chemistry Chemical Physics, 22(4), 2262-2275.

Liu, F., Liu, W., Zhou, S., Yang, C., Tian, M., Jia, G., ... & Wu, D. (2020). Identification of FABP5 as an immunometabolic marker in human hepatocellular carcinoma. Journal for immunotherapy of cancer, 8(2).

Carbonetti, G., Wilpshaar, T., Kroonen, J., Studholme, K., Converso, C., d’Oelsnitz, S., & Kaczocha, M. (2019). FABP5 coordinates lipid signaling that promotes prostate cancer metastasis. Scientific reports, 9(1), 1-16.

Lv, Q., Wang, G., Zhang, Y., Han, X., Li, H., Le, W., ... & Ding, Q. (2019). FABP5 regulates the proliferation of clear cell renal cell carcinoma cells via the PI3K/AKT signaling pathway. International Journal of Oncology, 54(4), 1221-1232.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human FABP5 ELISA Kit (CAT#: V2LY-0626-LY1618)

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Isotype control

For research use only. Not intended for any clinical use.

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