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Human Recombinant FCGR1A protein, ECD, His Tag (V2LY-0526-LY2915)

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Datasheet
SDS
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host
HEK293 Cells
Protein Species
Human
Tag
His Tag
Protein Construction
This product is Human Recombinant FCGR1A protein, ECD, His Tag consist of Amino Acid: 1-288 and predicts a molecular mass of 32 kDa.
Molecule Mass
32 kDa
Protein Domain
ECD
Verified
HPLC
Sequence
Amino Acid: 1-288
Species
Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
≥95% as determined by SDS-PAGE. ≥90% as determined by SEC-HPLC. ≥90% as determined by SEC-MALS(Routinely tested).
Endotoxin
Please contact us for more information.
Format
Lyophilized
Reconstitution
Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.
Buffer
Lyophilized from sterile PBS
Preservative
None
Storage
Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
More Infomation

Target

Full Name
Fc Fragment Of IgG Receptor Ia
Alternative Names
Fc Fragment Of IgG Receptor Ia; Fc Fragment Of IgG, High Affinity Ia, Receptor For (CD64); Fc Fragment Of IgG, High Affinity Ia, Receptor (CD64); Fc Gamma Receptor Ia; IgG Fc Receptor I; Fc-Gamma RIA; Fc-Gamma RI; FcgammaRIa; IGFR1;
Research Area
High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses.
Biological Process
Cell surface receptor signaling pathway Source: GO_Central
Immune response Source: ProtInc
Innate immune response Source: UniProtKB-KW
Phagocytosis, engulfment Source: ProtInc
Positive regulation of protein tyrosine kinase activity Source: ARUK-UCL
Regulation of immune response Source: GO_Central
Signal transduction Source: ProtInc
Cellular Location
Cell membrane. Stabilized at the cell membrane through interaction with FCER1G.
Topology
Extracellular: 16-292
Helical: 293-313
Cytoplasmic: 314-374
PTM
Phosphorylated on serine residues.

Wu, J., Li, Y., Rendahl, A., & Bhargava, M. (2022). Novel Human FCGR1A Variants Affect CD64 Functions and Are Risk Factors for Sarcoidosis. Frontiers in immunology, 13, 841099.

Reddy, J. S., Wang, X., Allen, M., Carrasquillo, M. M., Biernacka, J. M., Jenkins, G. D., ... & Younkin, S. G. (2022). Polygenic risk score analysis identifies deleterious protein-coding variants in novel immune pathway genes ATP8B4, FCGR1A, and LILRB1 that associate with Alzheimer's disease. medRxiv.

Xu, J. L., & Guo, Y. (2020). FCGR1A serves as a novel biomarker and correlates with immune infiltration in four cancer types. Frontiers in molecular biosciences, 7, 581615.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Cynomolgus, Rhesus Recombinant FCGR1A protein, His Tag (CAT#: V2LY-0526-LY25)

Canine Recombinant FCGR1A protein, His Tag (CAT#: V2LY-0526-LY1225)

Canine Recombinant FCGR1A protein, His Tag-1 (CAT#: V2LY-0526-LY1226)

Human Recombinant FCGR1A protein, ECD, His Tag-1 (CAT#: V2LY-0526-LY2916)

Human Recombinant FCGR1A protein, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY2917)

Mouse Recombinant FCGR1A protein, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY8054)

Mouse Recombinant FCGR1A protein, His Tag (CAT#: V2LY-0526-LY8055)

Rabbit Recombinant FCGR1A protein, His Tag (CAT#: V2LY-0526-LY9120)

Rat Recombinant FCGR1A protein, His Tag (CAT#: V2LY-0526-LY9260)

Rhesus Recombinant FCGR1A protein, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY9688)

Antibody Pairs

FCGR1A Matched Antibody Pair (418) (CAT#: APMAB-418LY)

FCGR1A Matched Antibody Pair (419) (CAT#: APMAB-419LY)

Related Products

Mouse Anti-FCGR1A Recombinant Antibody (CBT4518) (CAT#: V2LY-0625-LY1005)

Rabbit Anti-FCGR1A Recombinant Antibody (CBFYC-0101) (CAT#: V2LY-0925-LY749)

Human Recombinant FCGR1A protein, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY2917)

Mouse Anti-FCGR1A Recombinant Antibody (102) (CAT#: CBMAB-C8745-LY)

Human Recombinant FCGR1A protein, ECD, His Tag-1 (CAT#: V2LY-0526-LY2916)

Rabbit Anti-FCGR1A Recombinant Antibody (CBFYC-2670) (CAT#: V2LY-0925-LY753)

Mouse Recombinant FCGR1A protein, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY8054)

Canine Recombinant FCGR1A protein, His Tag (CAT#: V2LY-0526-LY1225)

FCGR1A Matched Antibody Pair (418) (CAT#: APMAB-418LY)

FCGR1A Matched Antibody Pair (419) (CAT#: APMAB-419LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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