Human Recombinant FSHB protein, hFc Tag (V2LY-0526-LY4215)

Name: Human Recombinant FSHB protein, hFc Tag
SKU: V2LY-0526-LY4215
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

hFc Tag

Protein Construction

This product is Human Recombinant FSHB protein, hFc Tag consist of Amino Acid: 1-129 and predicts a molecular mass of 39.2 kDa.

Molecule Mass

39.2 kDa

Sequence

Amino Acid: 1-129

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>95% as determined by SDS-PAGE.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Follicle Stimulating Hormone Beta Subunit

Function

Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways (PubMed:2494176, PubMed:24692546).

Follitropin is involved in follicle development and spermatogenesis in reproductive organs (PubMed:407105, PubMed:8220432).

Biological Process

Female gamete generation Source: ProtInc
Female pregnancy Source: ProtInc
Follicle-stimulating hormone signaling pathway Source: GO_Central
G protein-coupled receptor signaling pathway Source: UniProtKB
Hormone-mediated signaling pathway Source: GO_Central
Positive regulation of bone resorption Source: Ensembl
Positive regulation of cell migration Source: BHF-UCL
Positive regulation of cell population proliferation Source: BHF-UCL
Positive regulation of gene expression Source: Ensembl
Positive regulation of steroid biosynthetic process Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Progesterone biosynthetic process Source: BHF-UCL
Regulation of osteoclast differentiation Source: Ensembl
Regulation of signaling receptor activity Source: UniProtKB
Sertoli cell proliferation Source: Ensembl
Spermatogenesis Source: Ensembl
Transforming growth factor beta receptor signaling pathway Source: BHF-UCL

Cellular Location

Secreted. Efficient secretion requires dimerization with CGA.

Involvement in disease

Hypogonadotropic hypogonadism 24 without anosmia (HH24):
A form of hypogonadotropic hypogonadism, a group of disorders characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. HH24 is characterized by primary amenorrhea in women, oligo or azoospermia with low to normal testosterone levels in men, and infertility.

Byambaragchaa, M., Park, A., Gil, S. J., Lee, H. W., Ko, Y. J., Choi, S. H., ... & Min, K. S. (2021). Luteinizing hormone-like and follicle-stimulating hormone-like activities of equine chorionic gonadotropin β-subunit mutants in cells expressing rat luteinizing hormone/chorionic gonadotropin receptor and rat follicle-stimulating hormone receptor. Animal Cells and Systems, 25(3), 171-181.

Wang, H. Q., Zhang, W. D., Yuan, B., & Zhang, J. B. (2021). Advances in the regulation of mammalian follicle-stimulating hormone secretion. Animals, 11(4), 1134.

Ongaro, L., Schang, G., Zhou, Z., Kumar, T. R., Treier, M., Deng, C. X., ... & Bernard, D. J. (2020). Human follicle-stimulating hormone ß subunit expression depends on FOXL2 and SMAD4. Endocrinology, 161(5), bqaa045.

Santi, D., Crépieux, P., Reiter, E., Spaggiari, G., Brigante, G., Casarini, L., ... & Simoni, M. (2020). Follicle-stimulating hormone (FSH) action on spermatogenesis: a focus on physiological and therapeutic roles. Journal of Clinical Medicine, 9(4), 1014.

Burow, S., Fontaine, R., von Krogh, K., Mayer, I., Nourizadeh-Lillabadi, R., Hollander-Cohen, L., ... & Weltzien, F. A. (2019). Medaka follicle-stimulating hormone (Fsh) and luteinizing hormone (Lh): Developmental profiles of pituitary protein and gene expression levels. General and comparative endocrinology, 272, 93-108.

Trevisan, C. M., de Oliveira, R., Christofolini, D. M., Barbosa, C. P., & Bianco, B. (2019). Effects of a polymorphism in the promoter region of the follicle-stimulating hormone subunit beta (FSHB) gene on female reproductive outcomes. Genetic Testing and Molecular Biomarkers, 23(1), 39-44.

Bousfield, G. R., & Harvey, D. J. (2019). Follicle-stimulating hormone glycobiology. Endocrinology, 160(6), 1515-1535.

Das, N., & Kumar, T. R. (2018). Molecular regulation of follicle-stimulating hormone synthesis, secretion and action. Journal of molecular endocrinology, 60(3), R131.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant FSHB protein, His Tag (CAT#: V2LY-0526-LY4216)

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Isotype control

For research use only. Not intended for any clinical use.

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