Human Recombinant GAP43 protein, His Tag (V2LY-0526-LY4258)

Name: Human Recombinant GAP43 protein, His Tag
SKU: V2LY-0526-LY4258
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Expressed Host

E. coli

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant GAP43 protein, His Tag consist of Amino Acid: Full Length and predicts a molecular mass of 48 kDa.

Molecule Mass

48 kDa

Sequence

Amino Acid: Full Length

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

Batch dependent.

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

MES, NaCl, CaCl2, Brij35

Preservative

None

Storage

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

More Infomation

Target

Full Name

Growth Associated Protein 43

Alternative Names

Growth Associated Protein 43; Axonal Membrane Protein GAP-43; Neural Phosphoprotein B-50; Neuron Growth-Associated Protein 43; Nerve Growth-Related Peptide GAP43; Calmodulin-Binding Protein P-57;

Function

This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.

Biological Process

Axon choice point recognition Source: GO_Central
Axon regeneration Source: GO_Central
Cell fate commitment Source: Ensembl
Glial cell differentiation Source: Ensembl
Protein kinase C-activating G protein-coupled receptor signaling pathway Source: ProtInc
Regulation of filopodium assembly Source: UniProtKB
Regulation of growth Source: UniProtKB-KW
Regulation of postsynaptic specialization assembly Source: Ensembl
Response to wounding Source: ProtInc
Tissue regeneration Source: GO_Central

Cellular Location

Cytoplasm; Cell membrane; Growth cone membrane; Filopodium membrane; Synapse; Perikaryon; Dendrite; Axon. Cytoplasmic surface of growth cone and synaptic plasma membranes.

PTM

Phosphorylated (By similarity). Phosphorylation of this protein by a protein kinase C is specifically correlated with certain forms of synaptic plasticity (By similarity).
Palmitoylated by ZDHHC3 (By similarity). Palmitoylation is regulated by ARF6 and is essential for plasma membrane association and axonal and dendritic filopodia induction (PubMed:14978216). Deacylated by LYPLA2 (PubMed:21152083).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant GAP43 protein, His Tag-1 (CAT#: V2LY-0526-LY4259)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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