Human Recombinant GDF15 protein, Biotin Conjugated, AVI & His Tag (V2LY-0526-LY4281)

Name: Human Recombinant GDF15 protein, Biotin Conjugated, AVI & His Tag
SKU: V2LY-0526-LY4281
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

E. coli

Protein Species

Human

Tag

AVI & His Tag

Protein Construction

This product is Human Recombinant GDF15 protein, Biotin Conjugated, AVI & His Tag consist of Amino Acid: 197-308 and predicts a molecular mass of 15.05 kDa.

Molecule Mass

15.05 kDa

Conjugates

Biotin

Sequence

Amino Acid: 197-308

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥95% as determined by SDS-PAGE.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Growth Differentiation Factor 15

Function

Regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099, PubMed:23468844, PubMed:29046435).

Binds to its receptor, GFRAL, and activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099).

It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which constitutes part of the 'emergency circuit' that shapes feeding responses to stressful conditions (PubMed:28953886).

On hepatocytes, inhibits growth hormone signaling (By similarity).

Biological Process

Activation of MAPK activity Source: UniProtKB
BMP signaling pathway Source: GO_Central
Cell-cell signaling Source: ProtInc
Glial cell-derived neurotrophic factor receptor signaling pathway Source: UniProtKB
Negative regulation of growth hormone receptor signaling pathway Source: UniProtKB
Negative regulation of multicellular organism growth Source: UniProtKB
Positive regulation of MAPK cascade Source: UniProtKB
Positive regulation of myoblast fusion Source: Ensembl
Positive regulation of pathway-restricted SMAD protein phosphorylation Source: GO_Central
Positive regulation of protein kinase B signaling Source: UniProtKB
Reduction of food intake in response to dietary excess Source: UniProtKB
Signal transduction Source: ProtInc
SMAD protein signal transduction Source: UniProtKB
Transforming growth factor beta receptor signaling pathway Source: ProtInc

Cellular Location

Secreted

Involvement in disease

Plasma levels are increased in children with concomitant heart disease and failure to thrive but not in children with heart disease and normal body weight.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Canine Recombinant GDF15 protein, hFc Tag (CAT#: V2LY-0526-LY1251)

Human Recombinant GDF15 protein, hFc Tag (CAT#: V2LY-0526-LY4282)

Human Recombinant GDF15 protein, hFc Tag-1 (CAT#: V2LY-0526-LY4283)

Human Recombinant GDF15 protein, His Tag (CAT#: V2LY-0526-LY4284)

Human Recombinant GDF15 (Mature Form) protein, His Tag (CAT#: V2LY-0526-LY4285)

Mouse Recombinant GDF15 protein, His Tag (CAT#: V2LY-0526-LY8354)

Rabbit Recombinant GDF15 protein, hFc Tag (CAT#: V2LY-0526-LY9125)

Related Products

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Mouse Anti-GDF15 Recombinant Antibody (CBWJN-0298) (CAT#: CBMAB-N0820-WJ)

Mouse Anti-GDF15 Recombinant Antibody (147627) (CAT#: CBMAB-G0311-LY)

Mouse Anti-GDF15 Recombinant Antibody (CBLG1-827) (CAT#: V2LY-1225-LY984)

Human Recombinant GDF15 protein, hFc Tag-1 (CAT#: V2LY-0526-LY4283)

Mouse Anti-GDF15 Recombinant Antibody (14B15) (CAT#: CBMAB-G2703-LY)

Mouse Anti-GDF15 Recombinant Antibody (CB283A) (CAT#: CBMAB-CA283LY)

Human Anti-GDF15 Recombinant Antibody (CBFYM-1096) (CAT#: V2LY-1225-LY988)

Mouse Anti-GDF15 Recombinant Antibody (CBWJN-0298) (CAT#: V2LY-1225-LY987)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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